Differential prefrontal and frontotemporal oxygenation patterns during phonemic and semantic verbal fluency

“…Semantic and phonological performances were similarly impaired in comparison with the reference group's performances excluding a ceiling effect involved in the absence of semantic fluency performance improvement. Therefore, this differential effect on 2 different cognitive tasks suggests that improvement in IPS might not be the only function that was improved by fampridine treatment [22,23,24]. The improvement of phonological fluency might indicate that fampridine also improved a specific cognitive function involved in phonological fluency and not in the semantic one in this population.…”

Section: Discussionmentioning

confidence: 96%

“…IPS and attention deficits impact both verbal fluencies [21,22]. Semantic fluency is considered to be more dependent on semantic stock and is based on the property of language for grouping named objects into categories, whereas phonological fluency is supposed to be more dependent on phonological memory and requires the creation of uncommon word recall strategies based on their lexical features and suppressing meaning-based responses [23,24]. Phonological fluency is supposed to have a more important executive component than semantic fluency.…”

Section: Introductionmentioning

confidence: 99%

Verbal Fluencies and Fampridine Treatment in Multiple Sclerosis

Magnin¹,

Sagawa²,

Chamard³

et al. 2015

Eur Neurol

View full text Add to dashboard Cite

Background/Aims: Fampridine is sometimes reported to improve cognition and especially the information-processing speed. Motor improvement might be a confounding factor. The aim of this study was to evaluate the effects of fampridine on verbal fluencies in patients with multiple sclerosis (MS). Methods: Fifty MS patients were included in a prospective monocentric open label trial with a mean Expanded Disability Status Scale of 5.3 ± 1.1. Assessments of verbal phonological and semantic fluencies were repeated twice (within 1 week) before fampridine treatment and twice after fampridine treatment in order to have the maximal practice effect. Gait velocity and fatigue (visual analogical scale) were also assessed. Distribution into gait responders, gait non-responders, fluency responders and fluency non-responders, was described. Results: Verbal fluencies were significantly higher after fampridine treatment. No correlation was observed between phonological fluency improvement and semantic fluency improvement. Gait responders and gait non-responders did not present significant differences in verbal fluency performance and fatigue score. No correlation between gait velocity improvement and fatigue improvement compared with verbal fluency improvement was observed. Conclusion: Our results suggest that fampridine could have a selective procognitive effect on phonological fluency in MS, even in the gait non-responder patients.

show abstract

“…Tupak et al [11] revealed lateralization of activation during a semantic verbal fluency task in healthy subjects. Lee et al [7] demonstrated reduced lateralization during a spatial WM task in patients with schizophrenia, suggesting that this finding might be the re-Kurume Medical Journal Vol.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Cortical Activation in Schizophrenia during the Card Game ^|^ldquo;Concentration^|^rdquo;

et al. 2012

View full text Add to dashboard Cite

Summary:Various functional imaging studies have demonstrated reduced lateralization of cortical activation during neurocognitive tasks in schizophrenia. -A well-known card game, "concentration", reflects working memory (WM). We compared characteristics of hemodynamic changes in the prefrontal to temporo-parietal areas of the brain during this card game between 24 outpatients with schizophrenia and 24 age-and gendermatched healthy control subjects. Using multi-channel near-infrared spectroscopy, we measured relative changes in oxygenated hemoglobin concentration (oxy-Hb changes), which reflects brain activity during this task. Patients showed reduced lateralization in the midfrontal area, which is involved in executive functions, and in the inferior parietal area, involved in WM subcomponents. We also found a significant negative correlation between left midfrontal region oxy-Hb changes and severity of negative symptoms of schizophrenia. Our results characterized disease-related features, suggesting the usefulness of oxy-Hb change measurement during this card game for assessing functional outcome in schizophrenic patients.

show abstract

Differential prefrontal and frontotemporal oxygenation patterns during phonemic and semantic verbal fluency

Cited by 71 publications

References 27 publications

Phonemic Verbal Fluency Is Associated with Pediatric Anxiety Disorders: Evidence from a Community Study

Phonemic Verbal Fluency Is Associated with Pediatric Anxiety Disorders: Evidence from a Community Study

Verbal Fluencies and Fampridine Treatment in Multiple Sclerosis

Characteristics of Cortical Activation in Schizophrenia during the Card Game ^|^ldquo;Concentration^|^rdquo;

Contact Info

Product

Resources

About