Differential presynaptic actions of pyrethroid insecticides on glutamatergic and GABAergic neurons in the hippocampus

Hossain, Muhammad M.; Suzuki, Tadahiko; Unno, Toshihiro; Komori, Seiichi; Kobayashi, Haruo

doi:10.1016/j.tox.2007.10.003

Cited by 32 publications

(25 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, a limited number of studies have attempted to examine potential roles of VGCC in pyrethroid effects using intact mammalian neuronal systems and in all cases failed to demonstrate a significant primary role for VGCC in pyrethroid effects (Meyer and Shafer, 2006;Meyer et al, 2008). Increased neurotransmitter release has been demonstrated after pyrethroid exposure in vivo (Hossain et al, 2004(Hossain et al, , 2005(Hossain et al, , 2008Mubarak Hossain, 2006). However, it is unclear whether this is caused by direct effects of these compounds on presynaptic VGCCs, or whether it is secondary to depolarization caused by pyrethroid actions on VGSCs.…”

Section: Downloaded Frommentioning

confidence: 99%

Mechanisms of Pyrethroid Insecticide-Induced Stimulation of Calcium Influx in Neocortical Neurons

Cao¹,

Shafer

Murray³

2010

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Pyrethroid insecticides bind to voltage-gated sodium channels (VGSCs) and modify their gating kinetics, thereby disrupting neuronal function. Pyrethroids have also been reported to alter the function of other channel types, including activation of voltage-gated calcium channels. Therefore, the present study compared the ability of 11 structurally diverse pyrethroids to evoke Ca 2ϩ influx in primary cultures of mouse neocortical neurons. Nine pyrethroids (tefluthrin, deltamethrin, -cyhalothrin, ␤-cyfluthrin, esfenvalerate, S-bioallethrin, fenpropathrin, cypermethrin, and bifenthrin) produced concentration-dependent elevations in intracellular calcium concentration (

show abstract

Section: Downloaded Frommentioning

confidence: 99%

Mechanisms of Pyrethroid Insecticide-Induced Stimulation of Calcium Influx in Neocortical Neurons

Cao¹,

Shafer

Murray³

2010

J Pharmacol Exp Ther

View full text Add to dashboard Cite

show abstract

“…In addition to voltage-sensitive sodium channel, voltage-sensitive calcium channels have been proposed as a target of deltamethrin (Symington and Clark, 2005;Symington et al, 2007;Hossain et al, 2008). Deltamethrin administration at the low dose on extracellular glutamate in the hippocampus in rats was blocked by tetrodotoxin, and at dose of 60 mg/kg deltamethrin on extracellular glutamate was prevented by L-type calcium channel blocker (Hossain et al, 2008). This result suggested that deltamethrin may act on both Na + and Ca 2+ channels to increase extracellular glutamate in the hippocampus.…”

Section: Discussionmentioning

confidence: 98%

“…It is reported that a large proportion of the septohippocampal projection is GABAergic and the septal GABAergic afferents terminate exclusively on hippocampal interneurous (Amaral and Kurz, 1985;Baisden et al, 1984;Freund, 1989;Freund and Buzsaki, 1996). The findings in Hossain et al (2008)'s study suggested that the effects of deltamethrin on hippocampal release of glutamate may involve direct effects on glutamatergic neurons and indirect effects on GABAergic and other neurons. Now, in our experiment we found that, compared to corn oil-treated mice, the levels of glutamate were increased in hippocampus of 0.92 and 1.8 mg/kg BW-dose groups.…”

Section: Discussionmentioning

confidence: 98%

“…Neurons depolarization can cause the nervous system excited, and the excited state cause the damage in the neurons (Soderlund et al, 2002). In addition to voltage-sensitive sodium channel, voltage-sensitive calcium channels have been proposed as a target of deltamethrin (Symington and Clark, 2005;Symington et al, 2007;Hossain et al, 2008). Deltamethrin administration at the low dose on extracellular glutamate in the hippocampus in rats was blocked by tetrodotoxin, and at dose of 60 mg/kg deltamethrin on extracellular glutamate was prevented by L-type calcium channel blocker (Hossain et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Amino acid neurotransmitters are major neurotransmitters in the brain which primarily include glutamate, gamma amino butyric acid (GABA) and aspartic acid (Asp), etc. Hossain et al (2008) reported that intraperitoneal injection of deltamethrin (10, 20, 60 mg/kg) could dose-dependently increased extracellular glutamate level to about 190-275% of baseline while decreasing the level of GABA in the hippocampus of rats. Niu et al (1999) found that intraperitoneal injection of deltamethrin at the dose of 20 mg/kg increased the contents of glutamate and Asp in the cerebral cortex, hippocampus, cerebellum of rats.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of sub-chronic exposure to deltamethrin on shuttle-box avoidance and contents of amino acid neurotransmitters in hippocampus of mice

Cao

Gao

et al. 2015

Fundam. Toxicol. Sci.

View full text Add to dashboard Cite

-The purpose of this study was to evaluate the effects of sub-chronic exposure to deltamethrin in lower doses on the acquisition of a two-way avoidance task and the levels of amino acid neurotransmitters in hippocampus of mice measured using shuttle-box and LC-MS/MS system. Deltamethrin was given to mice respectively at doses of 0.46, 0.92, 1.80 mg/kg BW daily for 60 days by gavage. Deltamethrin was found to decrease the number of avoidance responses, increase response latency, and increase glutamate levels in the 0.92 and 1.80 mg/kg BW-dose group. As revealed by electron microscopy, in 0.92 and 1.8 mg/kg-dose group mice, morphology of cells were changed and degeneration and necrosis morphological characteristics obviously were appeared. Collectively, results from this study suggest that deltamethrin may have cumulative effects in mice following repeated dosing of deltamethrin using moderately effective doses, beside Na + and Ca 2+ channels as well as Na + and Ca 2+ -dependent glutamate release, may be involved with neurotoxic action of deltamethrin.

show abstract

Acute Effects of Pyrethroids on Serotonin Release in the Striatum of Awake Rats: An In Vivo Microdialysis Study

Hossain

Suzuki

Richardson

et al. 2012

J Biochem & Molecular Tox

Self Cite

View full text Add to dashboard Cite

The present study examined the acute neurotoxic effects of three different pyrethroids, allethrin, cyhalothrin, and deltamethrin on the release of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the striatum of conscious rats using microdialysis. Allethrin 10 mg/kg reduced extracellular levels of 5-HT to 46%, whereas 20 and 60 mg/kg increased the release to 177% and 243% of baseline, respectively. Cyhalothrin increased 5-HT release to 145–204% and deltamethrin decreased to 58–32% of baseline in a dose-dependent manner. None of the pyrethroids tested altered extracellular levels of 5-HIAA. Local infusion of the voltage-gated sodium channel antagonist tetrodotoxin (TTX) into striatum completely prevented the effects of allethrin, cyhalothrin, and deltamethrin (10 and 20 mg/kg) on 5-HT release. The effect of deltamethrin at 60 mg/kg was completely abolished by striatal infusion of nimodipine (L-type Ca++ channel antagonist) with TTX. These findings suggest that pyrethroids disrupt the serotonergic neurotransmission in striatum in a dose-related manner with Na+ and Ca2+ channel-dependent mechanisms.

show abstract

Differential presynaptic actions of pyrethroid insecticides on glutamatergic and GABAergic neurons in the hippocampus

Cited by 32 publications

References 31 publications

Mechanisms of Pyrethroid Insecticide-Induced Stimulation of Calcium Influx in Neocortical Neurons

Mechanisms of Pyrethroid Insecticide-Induced Stimulation of Calcium Influx in Neocortical Neurons

Effects of sub-chronic exposure to deltamethrin on shuttle-box avoidance and contents of amino acid neurotransmitters in hippocampus of mice

Acute Effects of Pyrethroids on Serotonin Release in the Striatum of Awake Rats: An In Vivo Microdialysis Study

Contact Info

Product

Resources

About