Differential projections to the intralaminar and gustatory thalamus from the parabrachial area: A PHA-L study in the rat

Bester, Hervé; Bourgeais, Laurence; Villanueva, Luis; Besson, Jean‐Marie; Bernard, Jean‐François

doi:10.1002/(sici)1096-9861(19990322)405:4<421::aid-cne1>3.0.co;2-2

Cited by 113 publications

(72 citation statements)

References 139 publications

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“…1A. This is the portion of the thalamus that receives afferent input from the gustatory PbN in the hamster (20) and in the rat (4,45). A recording site marked with Chicago Sky Blue dye in the PbN is shown in Fig.…”

Section: Histologymentioning

confidence: 99%

“…For example, whereas the afferent projections from the PbN to the VPMpc were well documented, the efferent projections from the VPMpc to the PbN were not demonstrated (4,21,64). In…”

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confidence: 99%

“…central gustatory pathway; pons; electrophysiology THE PARABRACHIAL NUCLEI (PbN) and the parvicellular part of the ventroposteromedial nucleus of the thalamus (VPMpc) are the second and tertiary central relays for taste information processing in rodents, respectively (4,13,17,28,45,49,51). Gustatory information elicited from the tongue and oropharyngeal cavity is initially carried to the rostral portion of the nucleus of the solitary tract (NST) by the VIIth, IXth, and Xth cranial nerves, and these terminals are distributed in a topographic fashion with rostral-caudal sequence in the rostral NST (2,9,23,24,89).…”

mentioning

confidence: 99%

“…For example, whereas the afferent projections from the PbN to the VPMpc were well documented, the efferent projections from the VPMpc to the PbN were not demonstrated (4,21,64). In addition, while earlier studies have shown that the VPMpc is involved in taste detection and discrimination (32), sodium appetite (30,44), and CTA (37,92,93), more recent studies have demonstrated that the VPMpc has a minimal influence on innate taste preference (15,62,78), sodium appetite (14,65), or CTA (14,65).…”

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confidence: 99%

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Modulation of activity of gustatory neurons in the hamster parabrachial nuclei by electrical stimulation of the ventroposteromedial nucleus of the thalamus

Mao¹,

Cho²,

Li³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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(VPMpc) is positioned at the key site between the gustatory parabrachial nuclei (PbN) and the gustatory cortex for relaying and processing gustatory information via the thalamocortical pathway. Although neuroanatomical and electrophysiological studies have provided information regarding the gustatory projection from PbN to VPMpc, the exact relationship between PbN and VPMpc, especially the efferent projection involving VPMpc to PbN, is obscure. Here we investigated the reciprocal connection between these two gustatory relays in urethaneanesthetized hamsters. We recorded from 114 taste-responsive neurons in the PbN and examined their responsiveness to electrical stimulation of the VPMpc bilaterally. Stimulation of either or both of the ipsilateral or contralateral VPMpc antidromically activated 109 gustatory PbN neurons. Seventy-two PbN neurons were antidromically activated after stimulation of both sides of the VPMpc, indicating that taste neurons in the PbN project heavily to the bilateral VPMpc. Stimulation of VPMpc also orthodromically activated 110 of PbN neurons, including 106 VPMpc projection neurons. Seventyeight neurons were orthodromically activated bilaterally. Among orthodromic activations of the PbN cells, the inhibitory response was the dominant response; 106 cells were inhibited, including 10 neurons that were also excited contralaterally, indicating that taste neurons in the PbN are subject to strong inhibitory control from VPMpc. Moreover, stimulation of VPMpc altered taste responses of the neurons in the PbN, indicating that VPMpc modulates taste responses of PbN neurons. These results may provide functional insight of neural circuitry for taste processing and modulation involving these two nuclei.central gustatory pathway; pons; electrophysiology THE PARABRACHIAL NUCLEI (PbN) and the parvicellular part of the ventroposteromedial nucleus of the thalamus (VPMpc) are the second and tertiary central relays for taste information processing in rodents, respectively (4,13,17,28,45,49,51). Gustatory information elicited from the tongue and oropharyngeal cavity is initially carried to the rostral portion of the nucleus of the solitary tract (NST) by the VIIth, IXth, and Xth cranial nerves, and these terminals are distributed in a topographic fashion with rostral-caudal sequence in the rostral NST (2,9,23,24,89). From the NST, ascending gustatory fibers project to third-order taste cells within the PbN of the pons (7,22,42,46,(53)(54)(55)87). Two separate routes carry taste information from the PbN further to the forebrain taste areas and cortex: the ventral forebrain pathway that involves the central nucleus of the amygdala (CeA), the lateral hypothalamus (LH), the bed nucleus of the stria terminalis (BNST), the substantia innominata (3,12,16,21,31,33,34,41,47,63,64,71); and the thalamocortical pathway that is characterized by the involvement of the bilateral VPMpc, which, in turn, carries taste information to the gustatory cortex (GC) (5,25,45,48,51).The PbN is a critical neural substrate for a number...

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Section: Histologymentioning

confidence: 99%

“…For example, whereas the afferent projections from the PbN to the VPMpc were well documented, the efferent projections from the VPMpc to the PbN were not demonstrated (4,21,64). In…”

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Modulation of activity of gustatory neurons in the hamster parabrachial nuclei by electrical stimulation of the ventroposteromedial nucleus of the thalamus

Mao¹,

Cho²,

Li³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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“…From the mPBN the gustatory responsive neurons project to the gustatory thalamus (the VPMpc [3,131]) and later reach the IC [3,67,132]. However, in contrast to other sensory systems (except olfaction) where sensory input reaches the thalamus before getting to the cortex, the gustatory system shows a direct connection between the mPBN and the IC that bypasses the thalamus [21].…”

Section: The Gustatory System In the Ratmentioning

confidence: 99%

The Insular Cortex and the Amygdala: Shared Functions and Interactions

Moraga-Amaro¹,

Stehberg²

2012

The Amygdala - A Discrete Multitasking Manager

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Olfaction and Taste

Lorenzo

Youngentob

2003

Handbook of Psychology

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The ability to detect and interpret the chemicals in our environment affects nearly every aspect of our survival. The flavor of our food, i.e., the combination of its taste and smell, is used both to prompt ingestion of nutrients and to protect us from ingesting or inhaling toxins. In the study of taste and olfaction, there are certain as yet unresolved questions that date from the very earliest research into these areas. For example, there is continued debate on the nature of primary stimuli, on the mechanisms of transduction, and on the ways in which stimuli are encoded and interpreted by the nervous system. In this review, the current thinking about these questions, as well as some recent data that may help to resolve them, are outlined. Data from both animal and human models are used to show how technological advances, particularly in the realm of molecular neurobiology, are providing the tools for a new and more complete understanding of how we taste and smell the chemicals in our environment.

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Differential projections to the intralaminar and gustatory thalamus from the parabrachial area: A PHA-L study in the rat

Cited by 113 publications

References 139 publications

Modulation of activity of gustatory neurons in the hamster parabrachial nuclei by electrical stimulation of the ventroposteromedial nucleus of the thalamus

Modulation of activity of gustatory neurons in the hamster parabrachial nuclei by electrical stimulation of the ventroposteromedial nucleus of the thalamus

The Insular Cortex and the Amygdala: Shared Functions and Interactions

Olfaction and Taste

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