Differential proteomics of Zika virus (ZIKV) infection reveals molecular changes potentially involved in immune system evasion by a Brazilian strain of ZIKV

Tatara, Juliana Miranda; Rosa, Rafael Lopes da; Varela, Ana Paula Muterle; Teixeira, Tais F.; Sesterheim, Patrícia; Gris, Anderson; Driemeier, David; Moraes, Amanda Naiara Silva; Berger, Markus; Peña, Ramón Díaz; Roehe, Paulo Michel; Souza, Diogo Onofre Gomes de; Guimarães, Jorge A.; Campos, Alexandre Rosa; Santi, Lucélia; Beys‐da‐Silva, Walter O.

doi:10.1007/s00705-022-05629-x

Cited by 2 publications

(1 citation statement)

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“…The ZIKV infection activates the type I/II interferon pathway, increasing the expression of interferon-stimulating genes (ISGs) through the JAK/STAT signaling pathway. This activation in cardiac and vascular tissues post-infection induces cardiomyocyte apoptosis/sclerosis and impairs vascular cell reproduction and migration, contributing to cardiovascular injury [ 77 , 78 ]. Elevated levels of ISG15 can also affect vasoconstriction and dilation [ 79 ].…”

Section: Flaviviridae Viruses and Cardiovascular Diseasementioning

confidence: 99%

A Review on The Pathogenesis of Cardiovascular Disease of Flaviviridea Viruses Infection

Yang,

Gao,

et al. 2024

Viruses

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Members of the Flaviviridae family, encompassing the Flavivirus and Hepacivirus genera, are implicated in a spectrum of severe human pathologies. These diseases span a diverse spectrum, including hepatitis, vascular shock syndrome, encephalitis, acute flaccid paralysis, and adverse fetal outcomes, such as congenital heart defects and increased mortality rates. Notably, infections by Flaviviridae viruses have been associated with substantial cardiovascular compromise, yet the exploration into the attendant cardiovascular sequelae and underlying mechanisms remains relatively underexplored. This review aims to explore the epidemiology of Flaviviridae virus infections and synthesize their cardiovascular morbidities. Leveraging current research trajectories and our investigative contributions, we aspire to construct a cogent theoretical framework elucidating the pathogenesis of Flaviviridae-induced cardiovascular injury and illuminate prospective therapeutic avenues.

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Section: Flaviviridae Viruses and Cardiovascular Diseasementioning

confidence: 99%