Differential pulse voltammetric determination of homovanillic acid as a tumor biomarker in human urine after hollow fiber-based liquid-phase microextraction

Hrdlička, Vojtěch; Barek, Jiřı́; Navrátil, Tomáš

doi:10.1016/j.talanta.2020.121594

Cited by 24 publications

(9 citation statements)

References 58 publications

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“…The Si-CD@CdTe@CMIP had a broader determination range compared with other methods. The LOD of Si-CD@CdTe@CMIP was lower than that of trace analysis in previous studies. − ,− Importantly, the Si-CD@CdTe@CMIP method achieved the lower detection limit with a lower sample consumption of 18 μL, which proved that the Si-CD@CdTe@CMIP can be used for detection of trace samples.…”

Section: Resultsmentioning

confidence: 70%

“…Studies showed that the level of HVA decreases while the concentration of Al 3+ increases in PD patients. − Thus, simultaneous detection of HVA and Al 3+ is of great significance for the early diagnosis and monitoring of PD. Currently, the detection methods of HVA or Al 3+ included enzymatic immunological assays (EIA), liquid chromatography (LC), gas chromatography–mass spectrometry (GC–MS), and high-performance liquid chromatography (HPLC). − However, these methods have some shortcomings such as the lack of specificity, poor sensitivity, large reagent consumption, and individual determination …”

Section: Introductionmentioning

confidence: 99%

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Ratiometric Fluorescence Capillary Sensor-Integrated Molecular Imprinting for Simultaneous Detection of Two Biological Indicators of Parkinson’s Disease

Tang

Zhao

et al. 2022

Anal. Chem.

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This work proposed ratiometric fluorescence capillary sensing systemintegrated molecular imprinting with highly sensitive and selective detection for two biological indicators of Parkinson's disease (homovanillic acid (HVA) and Al 3+ ). In this research, the silicon carbon quantum dot and the near-infrared CdTe quantum dot as luminescence sources were doped to an imprinted layer, which was attached to the inner surface wall of an amino-functionalized capillary. The fluorescence emissions of the ratiometric fluorescence capillary-imprinted sensor at 434 and 707 nm were quenched by HVA, and only the fluorescence emission at 434 nm was quenched by Al 3+ . Ratiometric fluorescence capillary sensing system-integrated molecular imprinting was used to detect simultaneously HVA and Al 3+ with linearity over 1.0 × 10 −9 −2.5 × 10 −7 and 1.0 × 10 −9 −1.1 × 10 −7 M, respectively. The sensor showcased detection limitations of 8.7 × 10 −10 and 9.8 × 10 −10 M, indicating that the ratiometric fluorescence capillary sensing system-integrated molecular imprinting had great potential application for detecting HVA and Al 3+ in serum and urine samples. The ratiometric fluorescence capillary sensing system-integrated molecular imprinting achieved highly sensitive and selective detection of HVA and Al 3+ with a microvolume test dosage of 18 μL, which provided a new way for early diagnosis and disease monitoring of Parkinson's disease.

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Section: Resultsmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Ratiometric Fluorescence Capillary Sensor-Integrated Molecular Imprinting for Simultaneous Detection of Two Biological Indicators of Parkinson’s Disease

Tang

Zhao

et al. 2022

Anal. Chem.

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“…Troeger's/SPE PB pH 7.0 DPV 2.2 [49] L-leucine modified Sol-Gel-Carbon electrode PB pH 7.4 DPV 0.1 [50] Cu/GCE PB pH 7.2 SWV 1.0×10 −2 [51] Boron doped diamond electrode 0.1 mol L -1 1 HCl DPV 0.4 [52] Metal-doped zirconia /CPE BR pH 4 DPV 0.273 This work…”

Section: Electrochemical Application: Detection Of Cancer Biomarkersmentioning

confidence: 99%

Synthesis and characterization of nanostructured copper and lanthanum co‐doped zirconia for voltammetric sensing of tumor biomarkers

Abbas

Radwan

Khaled

et al. 2021

Electrochemical Science Adv

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Nanostructured ZrO 2 -based materials with their biocompatibility, excellent electrical, and surface charge properties became one of the best candidates for the electrochemical sensing applications. Here, synthesis of Zr 1-x Cu x La x O 2 compounds was achieved in nanoscale and fully characterized using XRD, TEM, DRS, and cyclic voltammetry. A mixture of monoclinic and cubic phases was detected for the undoped ZrO 2 (Z sample, x = 0). For the Cu-doped compounds, (ZFW1, x = 0.05 and ZFW2, x = 0.1), a combination of cubic fluorite and monoclinic phase were detected. The intensity of the monoclinic phase for the Cudoped was higher than that of the undoped ZrO 2 sample. Cu and La co-doped samples (ZL1C1, x = 0.05 and ZL2C2, x = 0.1) were stabilized in a single cubic phase structure. Therefore, their band gap dropped from (4.8 eV) for the undoped ZrO 2 to (1.49 eV) for the ZL1C1 sample and (2 eV) for the ZL2C2 sample. Voltammetric sensing of neurotransmitter metabolites (vanillylmandelic acid (VMA) and homovanillic acid (HVA)) was achieved using the modified electrodes due to their acquired high electrocatalytic and high electrochemical performance.

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“…The presence of vanillymandelic acid, produced almost exclusively in the human liver, present in human urea indicates the presence of tumor cells such as PCC, paraganglioma or neuroblastoma [ 16 ]. Since the 1970s, VMA has also been used as a biomarker of metabolic disorders such as dopamine excretion disorders, as well as neurological disorders such as autism, post-traumatic stress disorder, Parkinson’s disease or depression [ 17 ]. Mandelic acid derivatives are still poorly described in the literature.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic Characterization and Antioxidant Properties of Mandelic Acid and Its Derivatives in a Theoretical and Experimental Approach

et al. 2022

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The following article discusses the antioxidant properties of mandelic acid and its hydroxy and methoxy derivatives. The antioxidant capacity of these compounds is determined by DPPH, FRAP, CUPRAC and ABTS. The mechanisms underlying the antioxidant properties are described by BDE, IP, PDE, ETE and PA calculation method values and referenced to experimental data. Thermochemistry, HOMO/LUMO energies, dipole moments, charge distribution, IR, RAMAN, NMR frequencies, binding lengths and angles were calculated using the B3LYP method and the 6-311++G(d,p) basis set. The structure of mandelic acid and its derivatives was determined experimentally using IR and RAMAN spectroscopy.

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Differential pulse voltammetric determination of homovanillic acid as a tumor biomarker in human urine after hollow fiber-based liquid-phase microextraction

Cited by 24 publications

References 58 publications

Ratiometric Fluorescence Capillary Sensor-Integrated Molecular Imprinting for Simultaneous Detection of Two Biological Indicators of Parkinson’s Disease

Ratiometric Fluorescence Capillary Sensor-Integrated Molecular Imprinting for Simultaneous Detection of Two Biological Indicators of Parkinson’s Disease

Synthesis and characterization of nanostructured copper and lanthanum co‐doped zirconia for voltammetric sensing of tumor biomarkers

Spectroscopic Characterization and Antioxidant Properties of Mandelic Acid and Its Derivatives in a Theoretical and Experimental Approach

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