Differential pulse voltammetric determination of metformin using copper-loaded activated charcoal modified electrode

Gholivand, Mohammad Bagher; Mohammadi-Behzad, Leila

doi:10.1016/j.ab.2013.03.019

Cited by 29 publications

(19 citation statements)

References 40 publications

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“…6, the E p value shifts negatively with the increase of the solution pH so that in the pH range of 5.82-11.65, the slope of the linear regression line through the data points (-0.053 mV pH -1 ), which is very close to the theoretical value of -0.059 mV pH -1 , is consistent with the mechanism proposed for the metformin electro-oxidation based on the equal numbers of electrons and protons. 29,50 The two linear regions of the E p vs. pH plot intersect at about 11.65 (Fig. 6), which are close to the pK a2 value (11.5) of metformin.…”

Section: Effect Of Phsupporting

confidence: 53%

“…To solve these problems, modified electrodes have been applied for the detection of metformin. For example, pyrogallol, 27 BiVO 4, 28 copperloaded charcoal 29 , Cu-based coordination polymer/carbon nanotubes (CNTs), 30 and nickel oxide nanotubes/carbon microparticles 31 have been mixed with carbon paste to prepare modified electrodes for metformin detection. In the present study, a Cu-based metal-organic framework (MOF) has been utilized as an efficient electrode modifier for metformin detection.…”

Section: Introductionmentioning

confidence: 99%

“…Literature survey shows that very few attempts have been made to metformin detection using voltammetric techniques. [28][29][30][31] Thus, the aim of this work was to develop a new, simple and sensitive electroanalytical method for the determination of metformin in pharmaceutical formulations. The electrochemical sensor was a GC electrode simply modified with a Cu-based MOF (Cu-BTC) nanocrystals/multi-walled CNTs hybrid nanostructure.…”

Section: Introductionmentioning

confidence: 99%

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Determination of metformin at metal-organic framework (Cu-BTC) nanocrystals/multi-walled carbon nanotubes modified glassy carbon electrode

Hadi¹,

Poorgholi²,

Mostaanzadeh³

2016

S.Afr.j.chem.

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Glassy carbon (GC) electrode modified with Cu-based metal-organic frameworks (Cu-BTC, BTC = 1,3,5-benzenetricarboxylate) and multi-walled carbon nanotubes (CNTs) composites was developed. The Cu-BTCs were synthesized by two methods, traditional hydrothermal and ultrasonic irradiation methods. It was found that the Cu-BTC that was synthesized by the latter method, with mean crystallite sizes in the nanometers range, showed a higher impact on enhancing the electrocatalytic activity of the modified electrode toward the electro-oxidation of metformin compared to that synthesized with the former method with a larger crystallite size of micrometer-scale. The morphological characteristics of Cu-BTCs and Cu-BTC nanocrystals/CNTs modified GC electrode surface were characterized by scanning electron microscopy. The modified electrode showed excellent response of oxidation current for the determination of metformin. Under optimum conditions, the peak current showed good linearity with concentrations in the range of 0.5 µM to 25 µM and a detection limit of 0.12 µM, as well as good repeatability. The Cu-BTC nanocrystals/CNTs modified GC electrode was applied successfully to determine metformin in pharmaceutical samples with good accuracy. KEYWORDSMetal-organic framework, carbon nanotube, modified glassy carbon electrode, metformin, electroanalytical determination.

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Section: Effect Of Phsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Determination of metformin at metal-organic framework (Cu-BTC) nanocrystals/multi-walled carbon nanotubes modified glassy carbon electrode

Hadi¹,

Poorgholi²,

Mostaanzadeh³

2016

S.Afr.j.chem.

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“…The sa- behavior has been reported for electrooxidation of MET. [23][24][25][26] From figure (3), it was noted that the value of the anodic peak current in case of PYCPE (73.92 µA) is much higher than that in case of CPE (13.12 µA) indicating the enhancement effect of PY as an effective mediator resulted in a considerable improvement in the oxidation peak current of MET and thus the modified electrode showed a catalytic behavior in electrooxidation of MET.…”

Section: Electrochemical Behavior Of Metmentioning

confidence: 99%

“…1) is an orally administered antidiabetic that lowers glucose blood level by reducing hepatic glucose production and gluconeogenesis and by enhancing peripheral insulin sensitivity. [1][2][3] Published methods for the determination of MET are based on different techniques like capillary electrophoresis, 4,5 NMR spectrometry, 6 potentiometry, [7][8][9] spectrofluorimetry and spectrophotometry, [9][10][11][12][13][14][15][16][17][18][19][20] conductometry, 21,22 voltammetry, [23][24][25][26][27][28][29] IR spectrometry 30 and chromatography. [31][32][33][34][35][36][37][38][39] Although many of the reported methods are accurate and sensitive, they require the use of sophisticated equipment and expensive reagents.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste Electrode

Wm²,

Am³

2015

ACSi

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The electrooxidative behavior and determination of metformin hydrochloride, anti-hyperglycemic drug, on a pyrogallol modified carbon paste electrode were investigated using cyclic voltammetry and differential pulse voltammetry. Metformin hydrochloride shows an irreversible oxidation behavior over a wide interval of pH (Britton-Robinson buffers, pH 2-9). The peak current varied linearly in the range comprised between 8.0 × 10 -7 and 6.0 × 10 -6 mol/L with detection limit of 6.63 × 10 -8 mol/L and limit of quantification of 2.21 × 10 -7 mol/L. The method was proposed for the determination of metformin hydrochloride in dosage forms and urine.

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A rapid, simple and ultrasensitive spectrofluorimetric method for the direct detection of metformin in real samples based on a nanoquenching approach

2020

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Metformin (MET), as an oral antidiabetic and antihyperglycemic agent, is widely used to treat type II diabetes mellitus. Because of its increasing consumption, developing a fast, simple, and selective method to determine its concentration in biological samples (serum and urine) and pharmaceutical formulations (tablets) is of great interest. In this study, we used a FRET‐based fluorescent nanosensor (Tb–phen–AgNPs system) for sensitive detection of MET in tablet and serum samples. This method is based on the enhancing effect of MET on the emission intensity of the Tb–phen complex, which is quenched by AgNPs via energy transfer process (turn off–on mode). A good linear relationship between the MET concentration and enhanced emission intensity of the Tb–phen–AgNPs system was observed in the range of (0.75–3.7) × 10−6 M under optimum conditions. Limit of detection and limit of quantitation were calculated to be 0.43 × 10−6 M and 1.31 × 10−6 M, respectively. This method was successfully used to determine MET concentrations in pharmaceutical dosage form and in spiked serum sample. The obtained recoveries from pharmaceutical formulation and serum sample were in the range 86.75–98.97% and 85.10–100.96%, respectively. Collectively, our results indicated that the method described here is simple, sensitive, cost effective, and free from interference. Therefore, it can be used as an effective and routine method for the direct and rapid determination of MET levels in biological samples such as serum.

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Differential pulse voltammetric determination of metformin using copper-loaded activated charcoal modified electrode

Cited by 29 publications

References 40 publications

Determination of metformin at metal-organic framework (Cu-BTC) nanocrystals/multi-walled carbon nanotubes modified glassy carbon electrode

Determination of metformin at metal-organic framework (Cu-BTC) nanocrystals/multi-walled carbon nanotubes modified glassy carbon electrode

Voltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste Electrode

A rapid, simple and ultrasensitive spectrofluorimetric method for the direct detection of metformin in real samples based on a nanoquenching approach

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