Differential Recovery of<i>Candida</i>Species from Subgingival Sites in Human Immunodeficiency Virus-Positive and Healthy Children from Rio de Janeiro, Brazil

Portela, MB; Souza, Ivete Pomarico Ribeiro de; Costa, E. M. M. B.; Hagler, Allen N.; Soares, R. Félix; Santos, André Luis Souza dos

doi:10.1128/jcm.42.12.5925-5927.2004

Cited by 58 publications

(67 citation statements)

References 19 publications

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“…Oral candidiasis presents not a single clinical entity, but instead a spectrum of very different clinical variants (e.g. pseudomembranous candidiasis, erythematous candidiasis, denture stomatitis and angular cheilitis) [32][33][34]. Oropharyngeal candidiasis is the most common opportunistic fungal infection in patients infected with human immunodeficiency virus (HIV), occurring in as many as 90% patients at some point during the course of HIV disease [34][35][36].…”

mentioning

confidence: 99%

Aspartic Protease Inhibitors as Potential Anti-Candida albicans Drugs: Impacts on Fungal Biology, Virulence and Pathogenesis

Braga-Silva

Santos

2011

CMC

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Mycoses are still one of the most problematic illnesses worldwide, especially affecting immunocompromised individuals. The development of novel antifungal drugs is becoming more demanding every day, since existing drugs either have too many side effects or they tend to lose effectiveness due to the resistant fungal strains. In this scenario, Candida albicans is still the main fungal pathogen isolated in hospitals. Pathogenicity results essentially from modifications of the host defense mechanisms that secondarily initiate transformations in the fungal behavior. The pathogenesis of C. albicans is multifactorial and different virulence attributes are important during the various stages of infection. Some virulence factors, like the secreted aspartic proteases (Saps), play a role in several infection stages and the inhibition of one of the many stages may contribute to the containment of the pathogen and thus should help in the treatment of disease. Therefore, Saps are potential targets for the development of novel anti-C. albicans drugs. Herein, we review the beneficial properties of pepstatin A and aspartic-type protease inhibitors used in the anti-human immunodeficiency virus chemotherapy on C. albicans, with particular emphasis in the effects on Sap activity, proliferation, morphogenesis (yeasts into mycelia transformation), ultrastructural architecture, adhesion to mammalian cells and abiotic materials, modulation of unrelated virulence factors (e.g., surface glycoconjugates, lipases and sterol), experimental candidiasis infection as well as synergistic properties when conjugated with classical antifungals. Collectively, these positive findings have stimulated the search for novel natural and/or synthetic pharmacological compounds with anti-aspartic protease properties against the human opportunistic fungus C. albicans.

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confidence: 99%

Aspartic Protease Inhibitors as Potential Anti-Candida albicans Drugs: Impacts on Fungal Biology, Virulence and Pathogenesis

Braga-Silva

Santos

2011

CMC

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“…However the use of www.intechopen.com highly active antiretroviral therapy (HAART) was associated with decreases in the prevalence of oral diseases. In a study comparing the oral microbiology of HIV-positive children with that of controls, the prevalence of gingivitis was significantly higher in the HIV-positive group (89.4%) than in the healthy group (40.5%) (Portela et al, 2004). It was also found that the frequency of yeast isolation correlated positively with the severity of the gingival condition in the HIVinfected group, because 95% of infants who presented with Candida had inflammation of the gingivae.…”

Section: Hiv-associated Gingivitismentioning

confidence: 70%

Gingivitis in Children and Adolescents

Oredugba¹,

Ayanbadejo²

2012

Oral Health Care - Pediatric, Research, Epidemiology and Clinical Practices

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“…Portela et al in a series of studies on LGE demonstrated the possibility of Candida as the aetiological agent of LGE in HIV-infected patients. Subgingival plaque samples of HIV-infected children contained 42.3 % Candida species compared to 7.1 % HIV-negative children (Portela et al 2004 ). C. albicans was the most commonly recovered species, but other non-albicans species such as Candida dubliniensis , Candida glabrata and Candida tropicalis and mixed species were also present in the subgingival plaque samples.…”

Section: Microbiology Of Linear Gingival Erythemamentioning

confidence: 94%

Association of Candida with Linear Gingival Erythema in HIV-Infected Subjects

Seneviratne

Jayasinghe

2015

Oral Candidosis

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Linear gingival erythema (LGE) in HIV patients has a contentious association with Candida infection. Although now it is widely accepted that Candida contributes to the occurrence of LGE, still some controversy exists in the nature of its association as an aetiological agent. We will briefl y discuss the clinical picture of LGE. This will be followed by an update on insight of microbial association with the lesion, prevalence of LGE, diagnosis and treatment. The current hypothesis and proposed mechanism of the LGE are then discussed.

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Differential Recovery ofCandidaSpecies from Subgingival Sites in Human Immunodeficiency Virus-Positive and Healthy Children from Rio de Janeiro, Brazil

Cited by 58 publications

References 19 publications

Aspartic Protease Inhibitors as Potential Anti-Candida albicans Drugs: Impacts on Fungal Biology, Virulence and Pathogenesis

Aspartic Protease Inhibitors as Potential Anti-Candida albicans Drugs: Impacts on Fungal Biology, Virulence and Pathogenesis

Gingivitis in Children and Adolescents

Association of Candida with Linear Gingival Erythema in HIV-Infected Subjects

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