2015
DOI: 10.4172/2375-4273.c1.007
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Differential regulation of cytotoxicity pathway discriminating between HIV, HCV mono and co-infection identified by transcriptome profiling of PBMCs

Abstract: Background: Despite the easy accessibility and diagnostic utility of PBMCs and their potential to show distinct expression patterns associated with the accelerated disease progression in HIV/HCV co-infection, there has not been a systematic study focusing on the global dysregulations of the biological pathways in PBMCs from HIV, HCV mono-and co-infected individuals. This study aimed at identifying the transcriptome distinctions of PBMCs between these patient groups. Methods: Genome-wide transcriptomes of PBMCs… Show more

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