Differential Regulation of <i>Kiss1</i> Expression by Melatonin and Gonadal Hormones in Male and Female Syrian Hamsters

Ansel, Laura; Bolborea, Matei; Bentsen, Agnete H.; Klosen, Paul; Mikkelsen, Jens D.; Simonneaux, Valérie

doi:10.1177/0748730410361918

Cited by 90 publications

(112 citation statements)

References 54 publications

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“…Indeed, so far only a frequency of two daily peripheral bolus of Kp10 over 60 h caused ovulation in seasonally acyclic ewes , underlining the importance of the frequency of administration. Thirdly, Syrian and Siberian hamsters display different photoperiodic responses (Bartness et al 1993) and Kiss1 mRNA regulation by photoperiod is opposite in the arcuate nucleus of the two species (Greives et al 2007, Ansel et al 2010). These observations suggest there exist important differences regarding the effect and physiological roles of Kp in mediating photoperiodic control of the reproductive axis between Siberian and Syrian hamsters.…”

Section: Discussionmentioning

confidence: 97%

“…The reason for this difference could be a matter of peptide sequence. Because Syrian hamsters display marked photoperiodic variations in both Kiss1 and Kp expression with lower levels in SD (Revel et al 2006a, Ansel et al 2010, we investigated whether gonadotrophs responsiveness to Kp or GNRH depends on photoperiod. An acute injection of Kp54 increased FOS immunoreactivity in the pituitary of SD than of LD-adapted animals.…”

Section: Discussionmentioning

confidence: 99%

“…In the Syrian hamster, we have shown that Kiss1 mRNA levels in AVPV and ARC are significantly reduced under SD conditions and this effect is mediated by melatonin (Ansel et al 2010). Furthermore, chronic administration of Kp to SD hamsters via a central route reverses the inhibitory effect of melatonin by reactivating the HPG axis, pointing to Kp as a pivotal gatekeeper of seasonal reproduction (Revel et al 2006a).…”

Section: Introductionmentioning

confidence: 94%

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Peripheral kisspeptin reverses short photoperiod-induced gonadal regression in Syrian hamsters by promoting GNRH release

Ansel¹,

Bentsen²,

Ancel³

et al. 2011

Reproduction

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In seasonal breeders, reproduction is synchronised by day length via the pineal hormone melatonin. In short winter days (short day, SD), the Syrian hamster displays a complete gonadal atrophy together with a marked reduction in expression of kisspeptins (Kp), a family of potent hypothalamic stimulators of GNRH neurons. Both central and peripheral acute injections of Kp have been reported to activate the gonadotropic axis in mammals. The aim of this study was to determine if and how peripheral administration of Kp54 could restore gonadal function in photo-inhibited hamsters. Testicular activity of hamsters kept in SD was reactivated by two daily i.p. injections of Kp54 but not by chronic subcutaneous delivery of the same peptide via mini-pumps. Acute i.p. injection of Kp54-induced FOS (c-Fos) expression in a large number of GNRH neurons and pituitary gonadotrophs together with a strong increase in circulating testosterone. The activation of pituitary cells by Kp was inhibited by preadministration of the GNRH receptor antagonist acyline. Altogether, our results demonstrate that peripheral Kp54 activates the gonadotropic axis by stimulating GNRH release and indicate that an appropriate protocol of long-term systemic Kp administration can recrudesce a photo-inhibited reproductive axis.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

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Peripheral kisspeptin reverses short photoperiod-induced gonadal regression in Syrian hamsters by promoting GNRH release

Ansel¹,

Bentsen²,

Ancel³

et al. 2011

Reproduction

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“…For example, SD conditions suppress the expression of KiSS-1 in the AVPV in Syrian hamsters (Revel et al, 2006a;Ansel et al, 2010) but increase expression in the Arc of Siberian hamsters Simonneaux et al, 2009). SD conditions suppress the expression of KiSS-1 in the Arc of Syrian hamsters and Siberian hamsters Simonneaux et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Photoperiod regulates the differential expression of KiSS-1 and GPR54 in various tissues and sexes of striped hamster

Xue

Zhang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. In order to investigate how photoperiod affects the expression of KiSS-1/G-protein-coupled receptor 54 (GPR54), the hypothalamus, the ovaries and testicles of the striped hamster were studied following photoperiod treatment and melatonin injection. We found that the melatonin concentration in the blood of the striped hamster was consistent with the treated photoperiods and that the photoperiod had significant effects on KiSS-1 expression, but the effect of photoperiod on GPR54 expression differed among tissues and sexes. The relative expression of KiSS-1 in the gonads of the male and female striped hamster was significantly higher than that in the hypothalamus, while the difference in GPR54 between the gonads and hypothalamus was inconsistent between the male and female striped hamster. In the striped hamster injected with melatonin, the expression level of KiSS-1 in the gonads and hypothalamus of the male and female striped hamster was significantly decreased; the expression level of GnRH in the gonads was also significantly decreased; the expression of GPR54 in the hypothalamus was increased. In the hypothalamus, a significant positive correlation existed between KiSS-1 and GnRH expression, while a negative correlation was observed between 13895 Photoperiod regulates expression of KiSS-1 and GPR54 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 13894-13905 (2015) GPR54 and GnRH expression. These results suggest that the photoperiodmelatonin-KiSS-1-GnRH pathway plays an important role in the seasonal reproduction mechanism of the striped hamster. Additionally, photoperiod or melatonin may not be a direct regulatory factor of GPR54 expression.

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“…Kisspeptin stimulates GnRH release via G protein-coupled receptor GPR54 located at the surface of GnRH neurons resulting in activation of the HPG axis (Oakley et al 2009). In LD breeding rodents, melatonin inhibits secretion of kisspeptin from the hypothalamic arcuate nucleus (Revel et al 2006, Ansel et al 2010, and administration of kisspeptin restores the reproductive activity in SD conditions (Revel et al 2006, Ansel et al 2011. RFRP-1 and -3 peptides were originally identified as mammalian orthologs of gonadotropin inhibitory hormone (GnIH) that inhibits the HPG axis in birds (Tsutsui et al 2013).…”

Section: Regulatory Mechanism For Mammalian Seasonal Reproductionmentioning

confidence: 99%

Molecular basis for regulating seasonal reproduction in vertebrates

Nishiwaki‐Ohkawa

Yoshimura

2016

Journal of Endocrinology

109

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Animals that inhabit mid- to high-latitude regions exhibit various adaptive behaviors, such as migration, reproduction, molting and hibernation in response to seasonal cues. These adaptive behaviors are tightly regulated by seasonal changes in photoperiod, the relative day length vs night length. Recently, the regulatory pathway of seasonal reproduction has been elucidated using quail. In birds, deep brain photoreceptors receive and transmit light information to the pars tuberalis in the pituitary gland, which induces the secretion of thyroid-stimulating hormone. Thyroid-stimulating hormone locally activates thyroid hormone via induction of type 2 deiodinase in the mediobasal hypothalamus. Thyroid hormone then induces morphological changes in the terminals of neurons that express gonadotropin-releasing hormone and facilitates gonadotropin secretion from the pituitary gland. In mammals, light information is received by photoreceptors in the retina and neurally transmitted to the pineal gland, where it inhibits the synthesis and secretion of melatonin, which is crucial for seasonal reproduction. Importantly, the signaling pathway downstream of light detection and signaling is fully conserved between mammals and birds. In fish, the regulatory components of seasonal reproduction are integrated, from light detection to neuroendocrine output, in a fish-specific organ called the saccus vasculosus. Various physiological processes in humans are also influenced by seasonal environmental changes. The findings discussed herein may provide clues to addressing human diseases, such as seasonal affective disorder.

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Differential Regulation of Kiss1 Expression by Melatonin and Gonadal Hormones in Male and Female Syrian Hamsters

Cited by 90 publications

References 54 publications

Peripheral kisspeptin reverses short photoperiod-induced gonadal regression in Syrian hamsters by promoting GNRH release

Peripheral kisspeptin reverses short photoperiod-induced gonadal regression in Syrian hamsters by promoting GNRH release

Photoperiod regulates the differential expression of KiSS-1 and GPR54 in various tissues and sexes of striped hamster

Molecular basis for regulating seasonal reproduction in vertebrates

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