Differential regulation of low and high voltage-activated calcium channels in neonatal rat myocytes following chronic PKA modulation

Hui, Kwokyin; Arnot, Michelle I.; Shin, Hyung-Jin; Sun, Hong‐Shuo; Feng, Zhong‐Ping

doi:10.4161/chan.5.4.17121

Cited by 3 publications

(2 citation statements)

References 80 publications

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“…The transcriptional factors of the GLI family in mammals, including GLI1, GLI2, and GLI3 serve important roles in the SHH signaling pathway. SHH receptor binding also prevents inhibition by the downstream negative regulators SUFU and PKA [ 64 , 65 ]. Interestingly, the SHH ligand was not differentially expressed in this study.…”

Section: Discussionmentioning

confidence: 99%

Downregulated luteolytic pathways in the transcriptome of early pregnancy bovine corpus luteum are mimicked by interferon-tau in vitro

et al. 2021

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Background Maintenance of the corpus luteum (CL) beyond the time of luteolysis is essential for establishing pregnancy. Identifying the distinct features of early pregnancy CL remains unresolved, hence we analyzed here the transcriptome of CL on day 18 pregnant (P) and non-pregnant (NP) cows using RNA-Seq. CL of P cows expressed ISGs, verifying exposure to the pregnancy recognition signal, interferon-tau (IFNT), whereas the CL of NP cows had elevated luteal progesterone levels, implying that luteolysis had not yet commenced. Results The DEGs, IPA, and metascape canonical pathways, along with GSEA analysis, differed markedly in the CL of P cows from those of NP cows, at the same day of the cycle. Both metascape and IPA identified similar significantly enriched pathways such as interferon alpha/beta, sonic hedgehog pathway, TNFA, EDN1, TGFB1, and PDGF. However, type-1 interferon and sonic hedgehog pathways were positively enriched whereas most of the enriched pathways were downregulated in the P compared to NP samples. Thirty-four % of these pathways are known to be elevated by PGF2A during luteolysis. Notably, selective DEGs in luteinized granulosa cells were modulated by IFNT in vitro in a similar manner to their regulation in the CL of P cows. Conclusion This study unraveled the unique transcriptomic signature of the IFNT-exposed, early pregnancy CL, highlighting the abundance of downregulated pathways known to be otherwise induced during luteolysis. These and IFNT-regulated in vitro pregnancy-specific DEGs suggest that IFNT contributes to the characteristics and maintenance of early pregnancy CL.

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Section: Discussionmentioning

confidence: 99%

Downregulated luteolytic pathways in the transcriptome of early pregnancy bovine corpus luteum are mimicked by interferon-tau in vitro

et al. 2021

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“…Both 1 -and 2 -AR are coupled via G proteins to the effector enzyme adenylyl cyclase (AC), which converts the substrate Mg-ATP into the second messenger cyclic adenosine monophosphate (cAMP). Then, cAMP-dependent protein kinase A (PKA) mediates the phosphorylation of proteins involved in cardiomyocyte calcium (Ca 2+ ) handling [12][13][14], contributing to the regulation of multiple signaling pathways.…”

Section: Two Receptors Two Fates?mentioning

confidence: 99%

β-Adrenergic Over-Stimulation and Cardio-Myocyte Apoptosis: Two Receptors, One Organelle, Two Fates?

Branco¹,

Moreira²,

Cunha‐Oliveira³

et al. 2014

CDT

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Neuro-hormonal regulation of cardiac function via cathecol-amines results in increased heart rate and contractility. A persistent adrenergic tone, however, is an insult to the heart, affecting its regular homeostasis, altering morphology and gene expression patterns, as well as inducing apoptosis of cardio-myocytes. At the same time as being the main oxygen consumers, mitochondria are also key to the energy production required for the heart to maintain its vital functions and to integrate a series of signaling pathways that define the life and death of the cell. As α-adrenergic receptors (α-AR) orchestrate multiple biochemical events that can either trigger or inhibit cell death, mitochondria can act as a referee in the entire process. In fact, α-AR subtypes α1 and α2 activate various down-stream pathways which differently modulate intracellular calcium levels and production of mitochondrial reactive oxygen species (ROS). The delicate balance between an adaptive (cardio-protective) response resulting in increased contractility and activation of survival pathways, vs. cell death caused by calcium and ROS-induced mitochondrial disruption, along with evidence of their clinical and potential therapeutic translations, are reviewed in this communication.

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Modulation of low-voltage-activated T-type Ca2+ channels

Zhang¹,

Jiang²,

Snutch³

et al. 2013

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Low-voltage-activated T-type Ca²⁺ channels contribute to a wide variety of physiological functions, most predominantly in the nervous, cardiovascular and endocrine systems. Studies have documented the roles of T-type channels in sleep, neuropathic pain, absence epilepsy, cell proliferation and cardiovascular function. Importantly, novel aspects of the modulation of T-type channels have been identified over the last few years, providing new insights into their physiological and pathophysiological roles. Although there is substantial literature regarding modulation of native T-type channels, the underlying molecular mechanisms have only recently begun to be addressed. This review focuses on recent evidence that the Ca(v)3 subunits of T-type channels, Ca(v)3.1, Ca(v)3.2 and Ca(v)3.3, are differentially modulated by a multitude of endogenous ligands including anandamide, monocyte chemoattractant protein-1, endostatin, and redox and oxidizing agents. The review also provides an overview of recent knowledge gained concerning downstream pathways involving G-protein-coupled receptors. This article is part of a Special Issue entitled: Calcium channels.

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Differential regulation of low and high voltage-activated calcium channels in neonatal rat myocytes following chronic PKA modulation

Cited by 3 publications

References 80 publications

Downregulated luteolytic pathways in the transcriptome of early pregnancy bovine corpus luteum are mimicked by interferon-tau in vitro

Downregulated luteolytic pathways in the transcriptome of early pregnancy bovine corpus luteum are mimicked by interferon-tau in vitro

β-Adrenergic Over-Stimulation and Cardio-Myocyte Apoptosis: Two Receptors, One Organelle, Two Fates?

Modulation of low-voltage-activated T-type Ca2+ channels

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