Differential regulation of the expression of lipid metabolism-related genes with skeletal muscle type in growing chickens

Saneyasu, Takaoki; Kimura, Sayaka; Kitashiro, Ayana; Tsuchii, Nami; Tsuchihashi, Tatsuya; Inui, M.; Honda, Kazuhisa; Kamisoyama, Hiroshi

doi:10.1016/j.cbpb.2015.07.002

Cited by 7 publications

(7 citation statements)

References 31 publications

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“…It is well demonstrated that SREBP1 regulates lipogenesis through targeting PPARγ and C/EBPα transcription factors [ 48 ]. Besides, SREBP1 plays significant roles in regulating the expression of lipogenic genes involved in fatty acid and cholesterol synthesis, such as FASN, in skeletal muscle, liver, and adipose tissue [ 49 ]; as well as genes encoding the enzymes involved in FA and TG syntheses (key lipogenic enzyme), such as ACLY, ACACA, FASN, ELOVL6, and SCD [ 31 ] ( Figure 1 ). Besides, the dietary PUFAs in the chicken with a high-fat diet inhibit SREBP1 activity through different mechanisms.…”

Section: Main Transcription Factors Involved In Chicken Fat Metabomentioning

confidence: 99%

Molecular Regulation of Lipogenesis, Adipogenesis and Fat Deposition in Chicken

Nematbakhsh

Chong

Selamat

et al. 2021

Genes

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In the poultry industry, excessive fat deposition is considered an undesirable factor, affecting feed efficiency, meat production cost, meat quality, and consumer’s health. Efforts to reduce fat deposition in economically important animals, such as chicken, can be made through different strategies; including genetic selection, feeding strategies, housing, and environmental strategies, as well as hormone supplementation. Recent investigations at the molecular level have revealed the significant role of the transcriptional and post-transcriptional regulatory networks and their interaction on modulating fat metabolism in chickens. At the transcriptional level, different transcription factors are known to regulate the expression of lipogenic and adipogenic genes through various signaling pathways, affecting chicken fat metabolism. Alternatively, at the post-transcriptional level, the regulatory mechanism of microRNAs (miRNAs) on lipid metabolism and deposition has added a promising dimension to understand the structural and functional regulatory mechanism of lipid metabolism in chicken. Therefore, this review focuses on the progress made in unraveling the molecular function of genes, transcription factors, and more notably significant miRNAs responsible for regulating adipogenesis, lipogenesis, and fat deposition in chicken. Moreover, a better understanding of the molecular regulation of lipid metabolism will give researchers novel insights to use functional molecular markers, such as miRNAs, for selection against excessive fat deposition to improve chicken production efficiency and meat quality.

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Section: Main Transcription Factors Involved In Chicken Fat Metabomentioning

confidence: 99%

Molecular Regulation of Lipogenesis, Adipogenesis and Fat Deposition in Chicken

Nematbakhsh

Chong

Selamat

et al. 2021

Genes

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“…However, there have long been controversies about the meat quality and the nutritional value between juvenile and old-aged hens3637. Over the past few years, most studies have focused on the skeletal muscle of chicken before sexual maturation383940. However, until now, the epigenetic mechanisms responsible for breast meat quality between the juvenile and later laying-period hens remained poorly understood.…”

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confidence: 99%

Genome-wide DNA methylation profiles reveal novel candidate genes associated with meat quality at different age stages in hens

Zhang

Yan

et al. 2017

Sci Rep

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Poultry meat quality is associated with breed, age, tissue and other factors. Many previous studies have focused on distinct breeds; however, little is known regarding the epigenetic regulatory mechanisms in different age stages, such as DNA methylation. Here, we compared the global DNA methylation profiles between juvenile (20 weeks old) and later laying-period (55 weeks old) hens and identified candidate genes related to the development and meat quality of breast muscle using whole-genome bisulfite sequencing. The results showed that the later laying-period hens, which had a higher intramuscular fat (IMF) deposition capacity and water holding capacity (WHC) and less tenderness, exhibited higher global DNA methylation levels than the juvenile hens. A total of 2,714 differentially methylated regions were identified in the present study, which corresponded to 378 differentially methylated genes, mainly affecting muscle development, lipid metabolism, and the ageing process. Hypermethylation of the promoters of the genes ABCA1, COL6A1 and GSTT1L and the resulting transcriptional down-regulation in the later laying-period hens may be the reason for the significant difference in the meat quality between the juvenile and later laying-period hens. These findings contribute to a better understanding of epigenetic regulation in the skeletal muscle development and meat quality of chicken.

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“…One study has reported that the NADH dehydrogenase activity of chicken type IIc muscle fibers is intermediate between that of type IIa and type IIb fibers, but it was unclear whether the type IIc muscle fibers exhibit aerobic or anaerobic metabolism [17].…”

Section: Discussionmentioning

confidence: 99%

“…In chickens, in addition to type I and type II muscle fiber subtypes, the existence of tonic type muscle fibers has been reported [17]. Tonic type muscle fibers, such as type IIc muscle fibers, are classified as muscle fibers of unknown function in chickens.…”

Section: Discussionmentioning

confidence: 99%

“…The subtypes of chicken skeletal muscle fibers are classified as type I, type IIa, type IIb, type IIc, and tonic type, depending on the myosin heavy chain isoform. The function of type IIc muscle fibers is unknown [17]. In a previous study, three-dimensional (3D) electron microscopic analysis of the mitochondria of chicken type I muscle fibers of gastrocnemius muscle and type IIb muscle fibers of pectoralis major muscle was reported [9].…”

Section: Introductionmentioning

confidence: 99%

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Three-dimensional structural analysis of mitochondria composing each subtype of fast-twitch muscle fibers in chicken

Makida

Kametani

Hosotani

et al. 2022

The Journal of Veterinary Medical Science

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In a previous study, the three-dimensional structures of mitochondria in type I and type IIb muscle fibers of chicken were analyzed. The study reported differences in the shape of the mitochondria and the distribution of lipid droplets. In this study, we three-dimensionally analyzed mitochondria and lipid droplets of type II muscle fiber subtypes IIa, IIb, and IIc of chicken lateral iliotibial muscle in the same field of view using correlative light electron microscopy (CLEM) and array tomography methods.The reconstructed images showed that the mitochondria of type IIa muscle fiber were thick and aligned along the myofibrils, and many lipid droplets were embedded in the mitochondria. The mitochondria of type IIb muscle fibers were intermittent, aligned along the myofibrils, and showed contact between adjacent horizontal mitochondria. No lipid droplets were observed in type IIb muscle fiber. In type IIc muscle fiber, we observed irregularly shaped mitochondria with small diameters aligned along the myofibrils. Lipid droplets not only were embedded in the mitochondria but also existed independently in some cases. The combination of array tomography and CLEM methods enabled three-dimensional electron microscopic observation of mitochondria in different subtypes of type II muscle fibers. The subtypes of type II muscle fibers differed in mitochondrial occupancy and morphology and in lipid droplet distribution, and characteristics that had been demonstrated biochemically were also demonstrated ultrastructurally.

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Differential regulation of the expression of lipid metabolism-related genes with skeletal muscle type in growing chickens

Cited by 7 publications

References 31 publications

Molecular Regulation of Lipogenesis, Adipogenesis and Fat Deposition in Chicken

Molecular Regulation of Lipogenesis, Adipogenesis and Fat Deposition in Chicken

Genome-wide DNA methylation profiles reveal novel candidate genes associated with meat quality at different age stages in hens

Three-dimensional structural analysis of mitochondria composing each subtype of fast-twitch muscle fibers in chicken

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