1997
DOI: 10.1677/joe.0.1540319
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Differential regulation of tissue insulin-like growth factor-binding protein (IGFBP)-3, IGF-I and IGF type 1 receptor mRNA levels, and serum IGF-I and IGFBP concentrations by growth hormone and IGF-I

Abstract: The aims of this investigation were (1) to examine IGF-binding protein-3 (IGFBP-3) mRNA levels in candidate tissues which might be important sources for blood IGFBP-3 (liver and skin) and in a target tissue for IGF-I action (skeletal muscle), and (2) to examine the effects of a single dose (500 micrograms) of GH or IGF-I on IGFBP-3 message levels in these tissues since temporal responses (4, 8 and 24 h after the single subcutaneous dose of peptide to GH-deficient dwarf rats) would indicate which peptide is the… Show more

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Cited by 48 publications
(35 citation statements)
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“…Muscular pull may cause bone strain and growth (39). Muscle may also act as a source of anabolic hormones on bone (16), or a common factor may influence both tissues (13). In contrast to the femoral neck, at the lumbar spine there were no correlations between change in muscle mass and change in BMD.…”
Section: Discussionmentioning
confidence: 86%
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“…Muscular pull may cause bone strain and growth (39). Muscle may also act as a source of anabolic hormones on bone (16), or a common factor may influence both tissues (13). In contrast to the femoral neck, at the lumbar spine there were no correlations between change in muscle mass and change in BMD.…”
Section: Discussionmentioning
confidence: 86%
“…Second, loss of muscle may predispose to fracture in states of low bone mass due to increased fall risk and loss of protective tissue cushioning (12)(13)(14). Third, muscle tension on bone may be important for maintaining bone mineral density (BMD) (15), and muscle may act as a source of hormones that maintain bone density (16,17).…”
Section: Introductionmentioning
confidence: 99%
“…In this study we chose to examine hepatic mRNA expression of GHR, IGF-I and IGFBP-3 because GH has been shown to regulate the expression of these proteins in other mammalian species (Mathews et al 1986, Isgaard et al 1988, Zapf et al 1989, Sauerwein et al 1991, Ambler et al 1992, Bichell et al 1992, Baumbach & Bingham 1995, Lemmey et al 1997. Since the liver is a primary target for GH, expression of GHR, IGF-I and IGFBP-3 in this tissue is likely to reflect the effects of circulating GH.…”
Section: Discussionmentioning
confidence: 99%
“…In this study of the brushtail possum (Trichosurus vulpecula), we therefore set out to quantify gene expression for two elements of this pathway in the liver, GH receptor (GHR) and IGF-I. In several eutherian species, expression of both genes is stimulated by GH as well as other hormones (Mathews et al 1986, Sauerwein et al 1991, Ambler et al 1992, Lemmey et al 1997. We also chose to quantify liver gene expression of because this is also stimulated by GH (Lemmey et al 1997) and so could provide another indicator of tissue responsiveness to GH.…”
Section: Introductionmentioning
confidence: 99%
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