2000
DOI: 10.1002/1096-9861(20001030)426:4<587::aid-cne7>3.0.co;2-r
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Differential regulation of trophic factor receptor mRNAs in spinal motoneurons after sciatic nerve transection and ventral root avulsion in the rat

Abstract: After sciatic nerve lesion in the adult rat, motoneurons survive and regenerate, whereas the same lesion in the neonatal animal or an avulsion of ventral roots from the spinal cord in adults induces extensive cell death among lesioned motoneurons with limited or no axon regeneration. A number of substances with neurotrophic effects have been shown to increase survival of motoneurons in vivo and in vitro. Here we have used semiquantitative in situ hybridization histochemistry to detect the regulation in motoneu… Show more

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Cited by 98 publications
(58 citation statements)
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“…The use of in situ hybridization as a quantitative measure of gene induction is well established (Hammarberg et al, 2000;Ressler et al, 2002;Sugiyama et al, 2003). These results are consistent with a number of studies that report a selective induction of BDNF expression in the hippocampus during contextual and spatial learning (Kesslak et al, 1998;Hall et al, 2000;Schaaf et al, 2001).…”
Section: Discussionsupporting
confidence: 87%
“…The use of in situ hybridization as a quantitative measure of gene induction is well established (Hammarberg et al, 2000;Ressler et al, 2002;Sugiyama et al, 2003). These results are consistent with a number of studies that report a selective induction of BDNF expression in the hippocampus during contextual and spatial learning (Kesslak et al, 1998;Hall et al, 2000;Schaaf et al, 2001).…”
Section: Discussionsupporting
confidence: 87%
“…However, the application of high doses of BDNF after sciatic nerve injury has detrimental effects on axonal regeneration [45]. The expression of the high affinity BDNF receptor, TrkB, is reduced in MN after VRA [46], while the expression of p75, the low affinity receptor for the neurotrophin family including BDNF, is increased [47]. Blockade of p75 with specific antibodies reverts the detrimental outcome induced by high doses of BDNF, and thus demonstrates a role of p75 in this effect [45].…”
Section: Discussionmentioning
confidence: 99%
“…The immunohistochemistry methods used have been described previously (17,18). Cryosections (14 m) were cut at the level of the L4-L5 segment of the spinal cord for VRA and surrounding the injection site for intraparenchymal injections, respectively.…”
Section: Immunohistochemistrymentioning
confidence: 99%