Differential relationship of uric acid to mortality and clinical biomarkers of aging according to grip strength in older adults: a cohort study

Guo, Sin-Mei; Liu, Yen-Tze; He, Sin-Ru; Wu, Ming–Shiang; Tseng, Wei‐Ting; Wu, Ray-Chin; Wu, I-Chien

doi:10.18632/aging.202820

Cited by 7 publications

(2 citation statements)

References 68 publications

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“…SUA plays an important role in immune regulation and tumor suppression ( 22 ). Thus, the increased mortality from hypouricemia is partly due to the incidence of cancer ( 23 , 24 ). SUA is an antioxidant, can interact with hydrogen peroxide and hydroxyl radicals, and effectively removes free radicals, thus protecting vascular endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

The U-Shaped Relationship Between Serum Uric Acid and Long-Term All-Cause Mortality in Coronary Artery Disease Patients: A Cohort Study of 33,034 Patients

Zheng

Huang

et al. 2022

Front. Cardiovasc. Med.

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BackgroundAssociations between high serum uric acid (SUA) and cardiovascular diseases have been reported. However, few studies have been conducted to explore the relationship between SUA and long-term all-cause mortality in coronary artery disease (CAD) patients. Our study aims to investigate the relationship between SUA and long-term all-cause mortality in patients with CAD.MethodsFrom January 2007 to December 2018, we divided 33,034 patients with CAD admitted in the Guangdong Provincial People's Hospital into five groups (quintile 1: SUA <5.05 mg/dl, quintile 2: 5.05 mg/dl ≤ SUA <5.59 mg/dl, quintile 3:5.59 mg/dl ≤ SUA <6.8 mg/dl, quintile 4, 6.8 mg/dl ≤ SUA <7.93 mg/dl, and quintile 5, SUA ≥7.93 mg/d;). This study used Kaplan–Meier survival analysis to evaluate patient outcomes with different ranges of SUA. Cox proportional hazards regression models and restricted cubic spline were applied to determine the association between serum uric and long-term all-cause mortality.ResultsA total of 33,034 participants were recruited, including 24,780 (75.01%) men and 8,254 (24.99) women in this cohort study. Median follow-up was 4.91 years. We found that SUA is an independent risk factor of long-term all-cause mortality according to the result of Cox proportional hazards models. This study also illustrated an approximate U-shape association between SUA and all-cause mortality when compared with 5.95 mg/lL ≤ SUA <6.8 mg/dl, SUA <5.0 5mg/dl (adjusted hazard ratio (aHR) =1.13, 95% CI: 1.01–1.26, p = 0.03), and SUA ≥8 mg/dL (aHR = 1.18, 95% CI: 1.06-1.32, p = 0.003).ConclusionOur study indicated a U-shaped relationship between SUA and long-term all-cause mortality in patients with CAD. No matter whether SUA is too high or too low, it increased the all-cause mortality in the CAD population, which deserves to be closely monitored.

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Section: Discussionmentioning

confidence: 99%

The U-Shaped Relationship Between Serum Uric Acid and Long-Term All-Cause Mortality in Coronary Artery Disease Patients: A Cohort Study of 33,034 Patients

Zheng

Huang

et al. 2022

Front. Cardiovasc. Med.

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“…The occurrence of many diseases is closely related to dietary habits and lifestyle [1] . In the past decades, the consumption of high fructose diet and sugar-sweetened soft drinks has increased sharply.…”

Section: Introductionmentioning

confidence: 99%

Modulation of gut microbiota and serum metabolome by Apostichopus japonicus derived oligopeptide in high-fructose diet-induced hyperuricemia in mice

Zhou,

Wang,

Zhang

et al. 2024

Food Science and Human Wellness

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Fructose consumption has risen dramatically in recent decades due to the use of sucrose and high fructose corn syrup in beverages and processed foods, contributing to rising rates of hyperuricemia. The purpose of this experiment was to explore the anti-hyperuricemia effects of an active oligopeptide (GPSGRP) derived from sea cucumber in fructose induced hyperuricemia mouse model, and to clarify the underlying mechanism in sight of gut microbiota and serum metabolites. Peptide GPSGRP treatment rebalanced uric acid metabolism and alleviated inflammatory response in mice. In addition, treatment with GPSGRP decreased the abundance of Bacteroides and Proteobacteria at the phylum level, Muribaculum, Prevotella and Bacteroides at the genus level, and inhibited the related pathways of purine metabolism and glycolysis/gluconeogenesis metabolism. Moreover, serum metabolites, including linoleic acid, indole and its derivatives, arachidonic acid and uridine, as well as related metabolic pathways, such as tricarboxylic acid cycle, ketone production and sugar production, were altered in response to GPSGRP treatment. This study provides a valuable reference for the application and development of marine biological peptides in uric acid management.

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Interactive effect of serum uric acid and handgrip strength on all-cause mortality among Japanese community-dwelling people

et al. 2023

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Differential relationship of uric acid to mortality and clinical biomarkers of aging according to grip strength in older adults: a cohort study

Cited by 7 publications

References 68 publications

The U-Shaped Relationship Between Serum Uric Acid and Long-Term All-Cause Mortality in Coronary Artery Disease Patients: A Cohort Study of 33,034 Patients

The U-Shaped Relationship Between Serum Uric Acid and Long-Term All-Cause Mortality in Coronary Artery Disease Patients: A Cohort Study of 33,034 Patients

Modulation of gut microbiota and serum metabolome by Apostichopus japonicus derived oligopeptide in high-fructose diet-induced hyperuricemia in mice

Interactive effect of serum uric acid and handgrip strength on all-cause mortality among Japanese community-dwelling people

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