Differential release kinetics of cardiac biomarkers in off-pump coronary bypass

Singh, Satyajit; Kapoor, Aditya; Agarwal, Surendra Kumar; Pande, Shantanu; Sinha, Archana; Rai, Himanshu; Kumar, Sudeep; Tewari, Satyendra; Garg, Naveen; Majumdar, Gauranga; Chandra, Bipin; Goel, Pravin K.

doi:10.1177/0218492313504420

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…The results of the second study showed that valvular pathologies, such as AS and MR, were associated with higher preoperative NT-proBNP levels than CAD, upon admission to surgery. This finding was consistent with previous studies [106][107][108][109][110][111][112][113] . The novelty of this finding was that it held true, even after adjusting for known confounders.…”

Section: Nt-probnp and Phfsupporting

confidence: 94%

Implications of myocardial dysfunction before and after aortic valve intervention

Hultkvist

2019

Linköping University Medical Dissertations

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Section: Nt-probnp and Phfsupporting

confidence: 94%

Implications of myocardial dysfunction before and after aortic valve intervention

Hultkvist

2019

Linköping University Medical Dissertations

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“…High plasma concentrations of NT-proBNP and BNP postoperatively were associated with increased use of inotropic drugs and/or intra-aortic balloon pump 2,55,71,[73][74][75][76] . High levels of natriuretic peptides were also reported to be associated with adverse short-term outcome, such as prolonged ICU stay, ventilation time, in-hospital mortality and postoperative mortality 72,73,77,78 .…”

Section: Postoperative Bnp and Nt-probnp In Cardiac Surgerymentioning

confidence: 99%

NT-proBNP as a marker of postoperative heart failure in adult cardiac surgery

Jiang

2019

Linköping University Medical Dissertations

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Postoperative heart failure (PHF) remains the major cause of mortality after cardiac surgery. Unfortunately, generally accepted diagnostic criteria for PHF are lacking. This may explain why the evidence for the efficacy and safety of current treatment of PHF with inotropes is insufficient. In cardiology practice N-terminal pro-B-type natriuretic peptide (NT-proBNP) is an established biomarker for heart failure. However, the association between NT-proBNP and PHF after cardiac surgery needs further clarification. Glutamate is a key intermediate in myocardial metabolism, which may improve myocardial tolerance to ischemia and facilitate post-ischemic recovery. Glutamate was associated with a reduced risk of developing severe PHF in high-risk patients undergoing coronary artery bypass surgery (CABG). The aim of this thesis was to study the role of NT-proBNP for prediction and assessment of PHF in cardiac surgery (Paper I-III) and the impact of intravenous glutamate infusion on postoperative NT-proBNP after CABG (Paper IV). Paper I: We retrospectively studied the role of underlying heart disease for preoperative NT-proBNP in patients admitted for first time CABG (n=2226), aortic valve surgery (AVR) for aortic stenosis (AS) (n=406) and mitral valve surgery for mitral valve regurgitation (MR) (n=346) by adjusting for non-cardiac confounders (age, gender, obesity and renal function). The level of NT-proBNP in AS or MR was 1.67 (p<0.0001) and 1.41 times (p<0.0001) higher respectively than in coronary artery disease (CAD) after adjusting for confounders. Preoperative NT-proBNP was predictive of severe PHF in CAD and MR patients but less so in AS patients. Preoperative NT-proBNP emerged as an independent risk factor for severe PHF and postoperative mortality in CAD patients. Paper II-III: We prospectively studied the association between postoperative NT-proBNP and PHF in two cohorts, patients undergoing AVR for AS Eva Ahlgren Andersson, Head of the Department of Cardiothoracic and Vascular Surgery. For allowing me to pursue the scientific path and facilitating my research project. All the colleagues at the Department of Cardiothoracic and Vascular surgery and Cardiothoracic Anesthesia for being good friends and part of a good working climate.

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The Role of Natriuretic Peptides in Predicting Adverse Outcomes After Cardiac Surgery: An Updated Systematic Review

Rao,

Varghese,

Ansari

et al. 2024

The American Journal of Cardiology

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Differential release kinetics of cardiac biomarkers in off-pump coronary bypass

Abstract: Even in patients undergoing off-pump surgery, there is significant natriuretic peptide and myocardial enzyme release. Only B-type natriuretic peptide levels had an association with postoperative variables.

Cited by 4 publications

References 24 publications

Implications of myocardial dysfunction before and after aortic valve intervention

Implications of myocardial dysfunction before and after aortic valve intervention

NT-proBNP as a marker of postoperative heart failure in adult cardiac surgery

The Role of Natriuretic Peptides in Predicting Adverse Outcomes After Cardiac Surgery: An Updated Systematic Review

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