Differential responses of circulating and tissue adrenomedullin and gene expression to volume overload

Abstract

The major findings of the present study were 1) a rapid increase in plasma AM after the imposition of VOL in association with increased plasma aldosterone and PRA, 2) the contribution of several organs to this increase, and 3) a late increase in the AM messenger RNA (mRNA) level in the ventricles as VOL-induced ventricular hypertrophy developed.

Rapid Increase in Cardiac Adrenomedullin Gene Expression Caused by Acute Pressure Overload. Effect of the Renin-Angiotensin System on Gene Expression.

“…5 Similarly, we have found in a previous study that ventricular AM expression does not increase on days 1 or 5, but that it is increased significantly on day 14 in aortocaval shunt models. 6 All these data suggest that acute VOL induces ventricular AM gene expression at least after approximately 2 weeks. However, whether or not acute POL increases cardiac AM transcription remains controversial.…”

Cirrhotic cardiomyopathy

“…Elevated circulating levels of cardiac troponin 1, a specific marker of myocardial injury [31], have also been reported in cirrhosis without other causes of cardiac disease [32]. Similar elevated levels of adrenomedullin, a hormone involved in the regulation of vascular tone and natriuresis [33] as well as influencing myocardial inotropy [34,35], have been found in cirrhosis without clinical heart disease [36,37] as in patients with heart failure [38,39] and ventricular hypertrophy [40]. Adrenomedullin mediates its effects through its second messenger, cyclic adenosine mono-phosphate (cAMP), which, in turn, increases the production of nitric oxide (NO) [41].…”

Soluble Guanylate Cyclase Stimulation on Cardiovascular Remodeling in Angiotensin II–Induced Hypertensive Rats

“…Plasma levels of ANP were measured with a specific radioimmunoassay, as described previously, 21 and those of BNP with a commercially available kit (Peninsula Laboratories Inc).…”