Differential Responses of Rat Alveolar and Peritoneal Macrophages to Man-Made Vitreous Fibers in Vitro

Dörger, Martina; Münzing, Silvia; Allmeling, Anne-Marie; Meßmer, K.; Krombach, Fritz

doi:10.1006/enrs.2001.4234

Cited by 43 publications

(28 citation statements)

References 32 publications

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“…The most studied fiber is asbestos (1)(2)(3). Man-made mineral or vitreous fibers can also be bioactive, though their role in respiratory disease in humans is not yet well established and is an active area of study (4,5). There are more than 70 varieties of synthetic inorganic fibers, covering over 35,000 applications, with different physicochemical and morphological characteristics.…”

mentioning

confidence: 99%

Analysis of the biological and chemical reactivity of zeolite-based aluminosilicate fibers and particulates.

Fach

Waldman

Williams

et al. 2002

Environ Health Perspect

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Environmental and/or occupational exposure to minerals, metals, and fibers can cause lung diseases that may develop years after exposure to the agents. The presence of toxic fibers such as asbestos in the environment plus the continuing development of new mineral or vitreous fibers requires a better understanding of the specific physical and chemical features of fibers/particles responsible for bioactivity. Toward that goal, we have tested aluminosilicate zeolites to establish biological and chemical structure-function correlations. Zeolites have known crystal structure, are subject to experimental manipulation, and can be synthesized and controlled to produce particles of selected size and shape. Naturally occurring zeolites include forms whose biological activity is reported to range from highly pathogenic (erionite) to essentially benign (mordenite). Thus, we used naturally occurring erionite and mordenite as well as an extensively studied synthetic zeolite based on faujasite (zeolite Y). Bioactivity was evaluated using lung macrophages of rat origin (cell line NR8383). Our objective was to quantitatively determine the biological response upon interaction of the test particulates/fibers with lung macrophages and to evaluate the efficacy of surface iron on the zeolites to promote the Fenton reaction. The biological assessment included measurement of the reactive oxygen species by flow cytometry and chemiluminescence techniques upon phagocytosis of the minerals. The chemical assessment included measuring the hydroxyl radicals generated from hydrogen peroxide by iron bound to the zeolite particles and fibers (Fenton reaction). Chromatography as well as absorption spectroscopy were used to quantitate the hydroxyl radicals. We found that upon exposure to the same mass of a specific type of particulate, the oxidative burst increased with decreasing particle size, but remained relatively independent of zeolite composition. On the other hand, the Fenton reaction depended on the type of zeolite, suggesting that the surface structure of the zeolite plays an important role.

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mentioning

confidence: 99%

Analysis of the biological and chemical reactivity of zeolite-based aluminosilicate fibers and particulates.

Fach

Waldman

Williams

et al. 2002

Environ Health Perspect

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“…Einzelne Begründungen der Faservarietäten sind zu beachten. (Dörger et al 2000(Dörger et al , 2001Hamilton et al 2009;Ji et al 2012;Murphy et al 2012Murphy et al , 2013Poland et al 2008;Ye et al 1999Ye et al , 2001 (IARC 2002(IARC , 2009NTP 2010NTP , 2016.…”

Section: Mineralwolle (Schlackenwollfasern Glaswollfasern Steinwollunclassified

“…Fasern, deren Länge den Durchmesser eines Alveolarmakrophagen überschreiten, sind nicht oder nur unvollständig phagozy tierbar ("frustated phagocytosis") (Dörger et al 2000(Dörger et al , 2001Hamilton et al 2009;Ji et al 2012;Murphy et al 2012Murphy et al , 2013Ye et al 1999). In einer Studie mit Mäusen wird berichtet, dass peritoneale Makrophagen langgestreckte Fasern (Amosite, MWCNT) einer Länge > 15 µm nicht mehr phagozytieren können (Poland et al 2008).…”

Section: Clearanceunclassified

“…Eine Faserlänge von >14 µm kann somit als kritische Faser länge für das Auftreten einer "frustranen Phagozytose" in Mäusen angesehen wer den. Mit Alveolar und Peritonealmakrophagen von Ratten und Hamstern, die ge gen die Mineralfasern MMVF10 (Glasswollfasern, mediane Faserlänge ~ 16 µm) und MMVF21 (Steinwollfasern, mediane Faserlänge ~ 19 µm) exponiert waren, wurde in vitro eine "Frustrated Phagocytosis" beobachtet (Dörger et al 2000(Dörger et al , 2001. Bezüglich der Größe der Makrophagen gibt es speziesspezifische Unterschiede.…”

Section: Clearanceunclassified

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Faserstäube, anorganisch [MAK Value Documentation in German language, 2018]

Hartwig

Arand²

2018

The MAK‐Collection for Occupational Health and Safety

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The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has reevaluated the general aspects of the toxicity of inorganic fibrous dusts. As a first step a documentation on the effects caused by inhalation of inorganic fibrous dusts and the mode of action for their toxicity was set up. For the elucidation of the mechanism of the toxicity and carcinogenicity of fibers, data derived from studies with asbestos fibers were also considered, in order to obtain some knowledge with regard to the biological effects of the other inorganic fibrous dusts. The formation of tumors in the lungs and on serous membranes is mainly the result of inflammatory processes. Chronic inflammation and cell proliferation are caused by the impairment of fiber clearance, whereby inflammation‐promoting cytokines, growth factors, reactive oxygen (ROS) and nitrogen species (RNS) and chlorine radicals are released from the macrophages, inflammatory cells, alveolar cells and mesothelial cells. The generation of these radicals leads to genotoxic effects. In addition intracellular formation of ROS and RNS can be caused by the fibers themselves, as a result of their own surface reactivity. Fibers can stimulate cell receptors and inflammasomes. Each fiber dust group will be evaluated individually and, depending on the data available, may be classified in one of the categories for carcinogens. The Commission has already begun this procedure.

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“…Algunos autores refieren que las fibras más peligrosas serían aquellas que se presentan con una longitud superior a 8 µm y diámetro menor de 0,25 µm porque tras ser inhaladas pueden penetrar hasta las zonas más profundas del tracto respiratorio 2 . Así, fibras largas y cortas presentan un patrón diferente a la hora de ser eliminadas, las fibras cortas son capturadas por los macrófagos quienes las someten a disolución química/lixiviación, mientras las fibras largas, especialmente aquellas que son más largas de 20 µm, son eliminadas parcialmente por los macrófagos, por lo que no se logra una eliminación total de las mismas [3][4][5] .…”

Section: Biopersistenciaunclassified

Manejo de la fibra de vidrio en entorno laboral, potenciales efectos sobre la salud y medidas de control (Revisión)

et al. 2015

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Differential Responses of Rat Alveolar and Peritoneal Macrophages to Man-Made Vitreous Fibers in Vitro

Cited by 43 publications

References 32 publications

Analysis of the biological and chemical reactivity of zeolite-based aluminosilicate fibers and particulates.

Analysis of the biological and chemical reactivity of zeolite-based aluminosilicate fibers and particulates.

Faserstäube, anorganisch [MAK Value Documentation in German language, 2018]

Manejo de la fibra de vidrio en entorno laboral, potenciales efectos sobre la salud y medidas de control (Revisión)

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