Differential RNA expression of immune-related genes and tumor cell proximity from intratumoral M1 macrophages in acral lentiginous melanomas treated with PD-1 blockade

Kim, Seoree; Kim, Joo Ri; Lee, Ji Hyun; Moon, Suk‐Ho; Jo, Su In; Bae, Dong-Jun; Park, Minwoo; Lee, Sun Young; Kim, Jeong-Oh; Lee, Cookjin; Chun, Sang Hoon; Ko, Yoon Ho; Park, Gyeongsin; Kim, Sangjin; Kang, Jin Hyoung

doi:10.1016/j.bbadis.2022.166516

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

2022

DOI: 10.1016/j.bbadis.2022.166516

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Differential RNA expression of immune-related genes and tumor cell proximity from intratumoral M1 macrophages in acral lentiginous melanomas treated with PD-1 blockade

Seoree Kim

Joo Ri Kim

Ji Hyun Lee

et al.

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The current landscape of spatial biomarkers for prediction of response to immune checkpoint inhibition

Williams,

Frei,

Koessler

et al. 2024

npj Precis. Onc.

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Enabling the examination of cell-cell relationships in tissue, spatially resolved omics technologies have revolutionised our perspectives on cancer biology. Clinically, the development of immune checkpoint inhibitors (ICI) has advanced cancer therapeutics. However, a major challenge of effective implementation is the identification of predictive biomarkers of response. In this review we examine the potential added predictive value of spatial biomarkers of response to ICI beyond current clinical benchmarks.

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The current landscape of spatial biomarkers for prediction of response to immune checkpoint inhibition

Williams,

Frei,

Koessler

et al. 2024

npj Precis. Onc.

View full text Add to dashboard Cite

show abstract

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Differential RNA expression of immune-related genes and tumor cell proximity from intratumoral M1 macrophages in acral lentiginous melanomas treated with PD-1 blockade

Cited by 1 publication

References 52 publications

The current landscape of spatial biomarkers for prediction of response to immune checkpoint inhibition

The current landscape of spatial biomarkers for prediction of response to immune checkpoint inhibition

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