Differential role of specific cardiovascular neuropeptides in pain regulation: Relevance to cardiovascular diseases

Szczepañska‐Sadowska, Ewa; Cudnoch-Jędrzejewska, Agnieszka; Sadowski, Bogdan

doi:10.1016/j.npep.2020.102046

Cited by 10 publications

(14 citation statements)

References 316 publications

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“…Pain is a frequent symptom of CVD and plays an essential role in the regulation of the oxytocin system [ 163 , 164 , 165 , 166 ]. For instance, neuropathic pain significantly upregulates OXY mRNA expression in the SON and PVN neurons [ 167 ].…”

Section: Oxytocin and Vasopressin Secretion During Cardiovascular Disordersmentioning

confidence: 99%

“…Pain, induced by tissue incision, decreases OXY content in the PVN, but increases its release in the periaqueductal grey (PAG) and the caudate nucleus [ 168 ]. Oxytocin reduces the pain intensity [ 166 ] and changes in its secretion may play a role in the regulation of sensitivity to pain in CVD.…”

Section: Oxytocin and Vasopressin Secretion During Cardiovascular Disordersmentioning

confidence: 99%

“…Because pain and stress are strong stimulators of the vasopressinergic system [ 130 , 166 , 169 , 187 , 188 , 189 , 190 , 191 , 192 ], it is very likely that they play an essential role in the stimulation of vasopressin release in CVD. It has been suggested that the activation of hypothalamic vasopressinergic neurons by pain is regulated by norepinephrine and the stimulation of noradrenergic alpha receptors [ 192 ].…”

Section: Oxytocin and Vasopressin Secretion During Cardiovascular Disordersmentioning

confidence: 99%

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Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation

Szczepañska‐Sadowska

Wsol

Cudnoch-Jędrzejewska

et al. 2021

IJMS

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The neurons secreting oxytocin (OXY) and vasopressin (AVP) are located mainly in the supraoptic, paraventricular, and suprachiasmatic nucleus of the brain. Oxytocinergic and vasopressinergic projections reach several regions of the brain and the spinal cord. Both peptides are released from axons, soma, and dendrites and modulate the excitability of other neuroregulatory pathways. The synthesis and action of OXY and AVP in the peripheral organs (eye, heart, gastrointestinal system) is being investigated. The secretion of OXY and AVP is influenced by changes in body fluid osmolality, blood volume, blood pressure, hypoxia, and stress. Vasopressin interacts with three subtypes of receptors: V1aR, V1bR, and V2R whereas oxytocin activates its own OXTR and V1aR receptors. AVP and OXY receptors are present in several regions of the brain (cortex, hypothalamus, pons, medulla, and cerebellum) and in the peripheral organs (heart, lungs, carotid bodies, kidneys, adrenal glands, pancreas, gastrointestinal tract, ovaries, uterus, thymus). Hypertension, myocardial infarction, and coexisting factors, such as pain and stress, have a significant impact on the secretion of oxytocin and vasopressin and on the expression of their receptors. The inappropriate regulation of oxytocin and vasopressin secretion during ischemia, hypoxia/hypercapnia, inflammation, pain, and stress may play a significant role in the pathogenesis of cardiovascular diseases.

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Section: Oxytocin and Vasopressin Secretion During Cardiovascular Disordersmentioning

confidence: 99%

Section: Oxytocin and Vasopressin Secretion During Cardiovascular Disordersmentioning

confidence: 99%

Section: Oxytocin and Vasopressin Secretion During Cardiovascular Disordersmentioning

confidence: 99%

See 1 more Smart Citation

Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation

Szczepañska‐Sadowska

Wsol

Cudnoch-Jędrzejewska

et al. 2021

IJMS

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“…Neurons and glial cells release potent cardiovascular factors which regulate the function of neighboring cells and remote organs, while the heart, vessels, and kidneys, produce neuroactive factors, which are transported to the brain and modulate the function of the CNS [6][7][8][9][10][11]. Substantial evidence indicates that all classical neurotransmitters and several neuroactive peptides, which transmit information between the cardiovascular regions of the brain and the spinal cord, are also engaged in the regulation of cognition, emotions, pain, and behavior at the molecular level [12][13][14][15][16][17]. Moreover, it has been shown that brain diseases are often associated with cardiovascular disturbances [15,[18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

“…Several neuropeptides, initially known as the cardiovascular agents, such as angiotensins, vasopressin, and oxytocin, have been identified as effective modulators of cognitive functions, pain, stress, and emotions [16,17,[22][23][24]. Moreover, these compounds frequently interact with other neuroactive agents and their interaction can be altered in cardiovascular pathologies [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Multiple Aspects of Inappropriate Action of Renin–Angiotensin, Vasopressin, and Oxytocin Systems in Neuropsychiatric and Neurodegenerative Diseases

Szczepañska‐Sadowska

Wsol

Cudnoch‐Jędrzejewska

et al. 2022

JCM

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The cardiovascular system and the central nervous system (CNS) closely cooperate in the regulation of primary vital functions. The autonomic nervous system and several compounds known as cardiovascular factors, especially those targeting the renin–angiotensin system (RAS), the vasopressin system (VPS), and the oxytocin system (OTS), are also efficient modulators of several other processes in the CNS. The components of the RAS, VPS, and OTS, regulating pain, emotions, learning, memory, and other cognitive processes, are present in the neurons, glial cells, and blood vessels of the CNS. Increasing evidence shows that the combined function of the RAS, VPS, and OTS is altered in neuropsychiatric/neurodegenerative diseases, and in particular in patients with depression, Alzheimer’s disease, Parkinson’s disease, autism, and schizophrenia. The altered function of the RAS may also contribute to CNS disorders in COVID-19. In this review, we present evidence that there are multiple causes for altered combined function of the RAS, VPS, and OTS in psychiatric and neurodegenerative disorders, such as genetic predispositions and the engagement of the RAS, VAS, and OTS in the processes underlying emotions, memory, and cognition. The neuroactive pharmaceuticals interfering with the synthesis or the action of angiotensins, vasopressin, and oxytocin can improve or worsen the effectiveness of treatment for neuropsychiatric/neurodegenerative diseases. Better knowledge of the multiple actions of the RAS, VPS, and OTS may facilitate programming the most efficient treatment for patients suffering from the comorbidity of neuropsychiatric/neurodegenerative and cardiovascular diseases.

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