Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin

Carlini, Valeria Paola; Varas, Mariana; Cragnolini, Andrea B.; Schiöth, Helgi B.; Scimonelli, Teresa Nieves; Barioglio, Susana Rubiales de

doi:10.1016/j.bbrc.2003.11.150

Cited by 316 publications

(228 citation statements)

References 28 publications

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“…In one of these studies, i.c.v. administration of ghrelin or its direct microinjection into the hippocampus, amygdale, or dorsal raphe nucleus induced anxiety-like behaviors in certain rat strains in the elevated plus maze, open field test and step-down/inhibitory avoidance test (Carlini et al 2002(Carlini et al , 2004. Also, both intra-third cerebroventricular and intraperitoneal administration of ghrelin to mice decreased duration of time in and number of entries into the open arms of an elevated plus maze when assessed ten minutes after injection (Mortensen et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Effects of Toxoplasma gondii infection on anxiety, depression and ghrelin level in male rats

et al. 2014

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The aim of the present study was to determine the effects of Toxoplasma gondii (T. gondii) infection on anxiety, depression and ghrelin level in male rats. Twenty four male rats were assessed in two equal groups. T. gondii tachyzoite (ip) were injected in infected group and control group received (2 ml) physiological serum (ip). Elevated plus Maze and swimming tests were used to assess anxiety and depression in rats respectively. The ghrelin and T. gondii IgG serum levels were measured by enzyme immunoassay kits. The Student's t test and Pearson correlation coefficient were used. The ghrelin serum level was significantly lower in the infected rats than control (P = 0.03). There were no significant differences in the depression and anxiety behavior between two groups. However, here were no significant correlations between ghrelin level and anxiety or depression in rats. It seems that latent T. gondii infection decreases the ghrelin serum level but does not change anxiety and depression like behaviors.

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Section: Discussionmentioning

confidence: 99%

Effects of Toxoplasma gondii infection on anxiety, depression and ghrelin level in male rats

et al. 2014

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“…In rodents, acute peripheral, as well as central ghrelin injection (both ICV and site specific: amygdala, dorsal raphe nucleus, hippocampus) induce anxiety-like behaviour (Asakawa et al, 2001, Carlini et al, 2002, Carlini et al, 2004. Furthermore, suppression of central ghrelin action by administration of antisense DNA for ghrelin caused a decrease in anxiety-and depression-like behaviour in rats (Kanehisa et al, 2006).…”

Section: 2mentioning

confidence: 99%

Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence

et al. 2011

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“…Therefore, one should not assume that a given feeding-related gene expressed in, e.g., the hippocampus, does not affect consumption at all. For example, Carlini et al have recently shown that the growth hormone secretagogue (GHS) receptor expressed in the dorsal raphe nucleus and hippocampus mediates consummatory responses to ghrelin (Carlini et al, 2004). Hence, expression level of the gene encoding for the GHS receptor outside the brainstem-hypothalamic network may certainly influence ingestive behavior.…”

Section: Aba Perspective On Feeding-related Central Network: System Omentioning

confidence: 99%

Analysis of the network of feeding neuroregulators using the Allen Brain Atlas

Olszewski

Cedernaes

Olsson

et al. 2008

Neuroscience & Biobehavioral Reviews

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The Allen Brain Atlas, the most comprehensive in situ hybridization database, covers over 21000 genes expressed in the mouse brain. Here we discuss the feasibility to utilize the ABA in research pertaining to the central regulation of feeding and we define advantages and vulnerabilities associated with the use of the atlas as a guidance tool. We searched for 57 feeding-related genes in the ABA, and of those 42 display distribution consistent with that described in previous reports. Detailed analyses of these 42 genes in the nucleus accumbens, ventral tegmental area, nucleus of the solitary tract, lateral hypothalamus, arcuate, paraventricular, ventromedial and dorsomedial nuclei suggests that molecules involved in feeding stimulation and termination are coexpressed in multiple consumption-related sites. Gene systems linked to energy needs, reward or satiation display a remarkably high level of overlap. This conclusion calls into question the classical concept of brain sites viewed as independent hunger or reward "centers" and favors the theory of a widespread feeding network comprising multiple neuroregulators affecting numerous aspects of consumption. KeywordsCNS; food intake; obesity; anorexia; neuropeptides The Allen Brain Atlas: Brief OverviewThe human brain is undoubtedly the organ of the body that we have the least knowledge about in relationship to its complexity. It has been estimated that 99% of the neuroscience literature focuses on only 1% of the genes expressed in the brain (Gewin, 2005). Deciphering spatial gene expression patterns in the central nervous system is crucial for our understanding of functional neuronal networks. It has been speculated that "in the brain, more than any other organ, function follows form" (Gewin, 2005).Correspondence and reprint requests should be addressed to: Pawel K. Olszewski, Ph.D. Department of Neuroscience, Uppsala University, BMC, Box 593, 751 24 Uppsala, Sweden. Tel ++46184714362 Fax ++4618511540 E-mail: pawel.olszewski@neuro.uu.se. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Gong et al., 2003)]. Moreover, it also contains expression patterns from transgenic mouse lines that express green fluorescent protein (EGFP) reporter gene in cells that normally express a gene of interest. The GENSAT provides comprehensive information about the limited number of the mapped genes. Another project is the GenePaint atlas (www.genepaint.org), which displays in situ hybridization data of several thousand genes in selected sections of whole mouse embryos at embryonic day (E) 14.5 and as well as some genes in E10.5 embryos, E1...

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Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin

Cited by 316 publications

References 28 publications

Effects of Toxoplasma gondii infection on anxiety, depression and ghrelin level in male rats

Effects of Toxoplasma gondii infection on anxiety, depression and ghrelin level in male rats

Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence

Analysis of the network of feeding neuroregulators using the Allen Brain Atlas

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