Differential roles of the dorsal hippocampal regions in the acquisition of spatial and temporal aspects of episodic-like memory

Mid-life Cardiovascular Risk Impacts Memory Function

“…The additional relationships involving greater error production at immediate recall implicate the hippocampus’ CA3 sub-region and dentate gyrus, both of which have been linked to acquisition of new information. 33-35 The novel finding of new error production at delayed recall is consistent with functional MRI studies also reporting that CA1 and subicular cortices 36,37 and projections to the medial prefrontal cortex are linked to retrieval 38 and differentiation of new from old information. 39 The posterior parahippocampal cortex has also been postulated to be involved in retrieval of contextual information.…”

Dopamine D1/D5 receptors in the dorsal hippocampus are required for the acquisition and expression of a single trial cocaine-associated memory

“…In this context, during single trial cocaine CPP, two distinct surges of DA levels were found in the dorsal hippocampus: one directly related to cocaine administration that lasted for about 4-5 h, and another starting 13 h post conditioning, which appears to be involved in the persistence of LTM storage of cocaine CPP memory (Kramar et al, 2014). Based on our present results, we suggest that pre-conditioning blockade of D1/D5 DA receptors in the dorsal hippocampus impedes acquisition of CPP because it may block novelty detection (Barbosa, Pontes, Ribeiro, Ribeiro, & Silva, 2012;Lisman & Grace, 2005) and/or motivational saliencerelated signals (Bromberg- Martin, Matsumoto, & Hikosaka, 2010) conveyed by dopaminergic inputs at the time of training. If this were the case, early or late post-conditioning blockade of hippocampal D1/D5 receptors would not alter CPP memory consolidation.…”

c-Fos expression correlates with performance on novel object and novel place recognition tests

“…Along these lines, dorsal hippocampal sub-regions have also been related to novel-object detection in studies that used the inactivation approach. Research has recently shown that temporal inactivation of the DG and CA3 sub-regions during acquisition and consolidation on an object recognition test impaired spatial discrimination of objects, whereas inactivation of CA1 impaired both spatial and temporal discrimination (Freitas Barbosa et al, 2012).…”