The explosion outcome and diagnostics of core-collapse supernovae depend sensitively on the nature of the stellar progenitor, but most studies to date have focused exclusively on one-dimensional, spherically-symmetric massive star progenitors. We present some of the first core-collapse supernovae simulations of three-dimensional massive star supernovae progenitors, a 12.5-and a 15-M model, evolved in three-dimensions from collapse to bounce through explosion with the radiation-hydrodynamic code Fornax. We compare the results using those starting from three-dimensional progenitors to three-dimensional simulations of spherically-symmetric, one-dimensional progenitors of the same mass. We find that the models evolved in three dimensions during the final stages of massive star evolution are more prone to explosion. The turbulence arising in these multi-dimensional initial models serve as seed turbulence that promotes shock revival. Detection of gravitational waves and neutrinos signals could reveal signatures of pre-bounce turbulence.