Differential scanning calorimetry studies on sunscreen loaded solid lipid nanoparticles prepared by the phase inversion temperature method

Montenegro, Lucía; Sarpietro, Maria Grazia; Ottimo, Sara; Puglisi, Giovanni; Castelli, Francesco

doi:10.1016/j.ijpharm.2011.05.076

Cited by 37 publications

(18 citation statements)

References 18 publications

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“…The phase transition temperatures of colloidal dispersions were always much lower than that of the anhydrous lipid mixtures (Montenegro et al, 2011). The melting points of colloidal systems were distinctly decreased by about 3-8 C (Choi et al, 2004).…”

Section: Drug-excipient Compatibility Studies By Differential Scanninmentioning

confidence: 87%

Candesartan cilexetil loaded solid lipid nanoparticles for oral delivery: characterization, pharmacokinetic and pharmacodynamic evaluation

2014

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Candesartan cilexetil (CC) is used in the treatment of hypertension and heart failure. It has poor aqueous solubility and low oral bioavailability. In this work, CC loaded solid lipid nanoparticles (CC-SLNs) were developed to improve the oral bioavailability. Components of the SLNs include either of trimyristin/tripalmitin/tristearin, and surfactants (Poloxamer 188 and egg lecithin E80). The CC loaded nanoparticles were prepared by hot homogenization followed by ultrasonication method. The physicochemical properties, morphology of CC-SLNs were characterized, the pharmacokinetic and pharmacodynamic behaviour of CC-SLNs were evaluated in rats. Stable CC-SLNs having a mean particle size of 180-220 nm with entrapment efficiency varying in between 91-96% were developed. The physical stability of optimized formulation was studied at refrigerated and room temperature for 3 months. Further, freeze drying was tried for improving the physical stability. DSC and XRD analyses indicated that the drug incorporated into SLN was in amorphous form but not in crystalline state. The SLN-morphology was found to be nearly spherical by electron microscopic studies. Pharmacokinetic results indicated that the oral bioavailability of CC was improved over 2.75-fold after incorporation into SLNs. Pharmacodynamic study of SLNs in hypertensive rats showed a decrease in systolic blood pressure for 48 h, while suspension showed a decrease in systolic blood pressure for only 2 h. Taken together, these effects are due to enhanced bioavailability coupled with sustained action of CC in SLN formulation. Thus, the results conclusively demonstrated the role of CC-SLNs for a significant enhancement in oral bioavailability along with improved pharmacodynamic effect.

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Section: Drug-excipient Compatibility Studies By Differential Scanninmentioning

confidence: 87%

Candesartan cilexetil loaded solid lipid nanoparticles for oral delivery: characterization, pharmacokinetic and pharmacodynamic evaluation

2014

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“…Stable NLC with the size of ∼ 25 nm would be prepared and showed to protect degradation of β-carotene compared to the soybean-oil based nanoemulsions 49 . Montenegro et al 63 developed sunscreen loaded cetyl palmitate solid lipid nanoparticles (SLN) using the PIT method. All the SLN showed a mean size ranging from 30 -95 nm with a single peak distribution 63 .…”

Section: Applications Of the Pit Methods To Another Lipid-based Nanocamentioning

confidence: 99%

“…Montenegro et al 63 developed sunscreen loaded cetyl palmitate solid lipid nanoparticles (SLN) using the PIT method. All the SLN showed a mean size ranging from 30 -95 nm with a single peak distribution 63 . Recently, other SLN prepared by the PIT method have been developed by Gao and McClements 64 , indicating that SLN of Brij30/octadecane/water with a particle size < 200 nm can be formed and they were stable at a temperature below their melting point.…”

Section: Applications Of the Pit Methods To Another Lipid-based Nanocamentioning

confidence: 99%

Preparation of nanoemulsions by phase inversion temperature (PIT)

Jintapattanakit¹

2018

Pharm Sci Asia

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“…2 years ago, Montenegro et al . investigated by differential scanning calorimetry the interactions between SLNs components and loaded UV filters, BMDBM and octylmethoxycinnamate (OMC). When the two UV filters were coloaded into SLNs based on ceteth‐20 as main surfactant, the UV filters were stable but their loading capacity has been decreased.…”

Section: Introductionmentioning

confidence: 99%

Coencapsulation of Butyl‐Methoxydibenzoylmethane and Octocrylene into Lipid Nanocarriers: UV Performance, Photostability and in vitro Release

Niculae

Badea

Meghea

et al. 2013

Photochem & Photobiology

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The coencapsulation of two UV filters, butyl-methoxydibenzoylmethane (BMDBM) and octocrylene (OCT), into lipid nanocarriers was explored to develop stable cosmetic formulations with broad-spectrum photoprotection and slow release properties. Different types of nanocarriers in various concentrations of the two UV filters were tested to find the combination with the best absorption and release properties. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have been the two types of lipid nanocarriers used. The NLCs were based on either medium chain triglycerides (MCT) or squalene (Sq). The following physicochemical properties of the nanocarriers have been evaluated: particle size, morphology, zeta potential (ZP), entrapment efficiency, loading capacity, and thermal behavior. The nanocarriers have been formulated into creams containing low amounts of UV filters (2.5% BMDBM and 1% OCT). The best photoprotection results were obtained with the cream based on NLCs prepared with MCT, having a sun protection factor (SPF) of 17.2 and an erythemal UVA protection factor (EUVA-PF) of 50.8. The photostability of the encapsulated BMDBM filter was confirmed by subjecting the nanocarriers-based creams to in vitro irradiation. The prolonged UV-protection efficacy was coupled with a slow in vitro release of the synthetic UV filters, which followed the Higuchi release model.

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Differential scanning calorimetry studies on sunscreen loaded solid lipid nanoparticles prepared by the phase inversion temperature method

Cited by 37 publications

References 18 publications

Candesartan cilexetil loaded solid lipid nanoparticles for oral delivery: characterization, pharmacokinetic and pharmacodynamic evaluation

Candesartan cilexetil loaded solid lipid nanoparticles for oral delivery: characterization, pharmacokinetic and pharmacodynamic evaluation

Preparation of nanoemulsions by phase inversion temperature (PIT)

Coencapsulation of Butyl‐Methoxydibenzoylmethane and Octocrylene into Lipid Nanocarriers: UV Performance, Photostability and in vitro Release

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