Differential sensitivity of colorectal cancer cell lines to artesunate is associated with expression of beta-catenin and E-cadherin

Li, Lin-Na; Zhang, Huadong; Yuan, Si-Ming; Yang, Dawei; Wang, Lin; Sun, Zhixian

doi:10.1016/j.ejphar.2008.03.041

Cited by 38 publications

(22 citation statements)

References 31 publications

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“…Artesunate has shown its ability to revert cellular transitions allowing re-differentiation of tissues by negative control of Wnt-signaling pathway [89]. Notably, artesunate has been found to be more effective in less differentiated cell lines [89]. …”

Section: Artemisinins As Anticancer Drugsmentioning

confidence: 99%

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

Crespo-Ortiz

Wei

2012

Journal of Biomedicine and Biotechnology

323

267

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Improvement of quality of life and survival of cancer patients will be greatly enhanced by the development of highly effective drugs to selectively kill malignant cells. Artemisinin and its analogs are naturally occurring antimalarials which have shown potent anticancer activity. In primary cancer cultures and cell lines, their antitumor actions were by inhibiting cancer proliferation, metastasis, and angiogenesis. In xenograft models, exposure to artemisinins substantially reduces tumor volume and progression. However, the rationale for the use of artemisinins in anticancer therapy must be addressed by a greater understanding of the underlying mechanisms involved in their cytotoxic effects. The primary targets for artemisinin and the chemical base for its preferential effects on heterologous tumor cells need yet to be elucidated. The aim of this paper is to provide an overview of the recent advances and new development of this class of drugs as potential anticancer agents.

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Section: Artemisinins As Anticancer Drugsmentioning

confidence: 99%

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

Crespo-Ortiz

Wei

2012

Journal of Biomedicine and Biotechnology

323

267

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“…Since composition can vary by geographic area, season of the year, etc., multiple samples will need to be extracted and tested. In addition to conventional steam distillation, other methods (including supercritical fluid and microwave extraction coupled to SPME as applied to Artemisia species (29,60,61) should be employed. Combined with solvents ranging in polarity and more sensitive analytical techniques, the prospects for discovering new anticancer compounds will then be greatly enhanced.…”

Section: Methodological Approachmentioning

confidence: 99%

Anticancer activity of botanical compounds in ancient fermented beverages (Review)

McGovern

Christofidou‐Solomidou²,

Wang³

et al. 2010

Int J Oncol

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Abstract. Humans around the globe probably discovered natural remedies against disease and cancer by trial and error over the millennia. Biomolecular archaeological analyses of ancient organics, especially plants dissolved or decocted as fermented beverages, have begun to reveal the preliterate histories of traditional pharmacopeias, which often date back thousands of years earlier than ancient textual, ethnohistorical, and ethnological evidence. In this new approach to drug discovery, two case studies from ancient Egypt and China illustrate how ancient medicines can be reconstructed from chemical and archaeological data and their active compounds delimited for testing their anticancer and other medicinal effects. Specifically, isoscopoletin from Artemisia argyi, artemisinin from Artemisia annua, and the latter's more easily assimilated semi-synthethic derivative, artesunate, showed the greatest activity in vitro against lung and colon cancers. In vivo tests of these compounds previously unscreened against lung and pancreatic cancers are planned for the future.

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“…Shinto et al found Ki26894, a TbR-I kinase inhibitor, suppressed the invasiveness and EMT in scirrhous gastric cancer cells (101). Artesunate (an antimalarial agent) has been discovered to induce cell cycle arrest and apoptosis possibly by affecting the hyperactive Wnt pathway and reversing EMT in colorectal cell lines (102). The Src kinase inhibitor dasatinib has been proven to inhibit growth of breast cancer cells with EMT features (103).…”

Section: Clinical Prognostic Of Emt and Potential Emt-targeted Therapmentioning

confidence: 99%

Epithelial-mesenchymal transition and drug resistance in breast cancer (Review)

Huang

Ren

2015

International Journal of Oncology

129

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Abstract. Breast cancer is the leading cause of cancer death in women worldwide. Insensitivity of tumor cells to drug therapies is an essential reason arousing such high mortality. Epithelial-mesenchymal transition (EMT) is defined by the loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. It is well known that EMT plays an important role in breast cancer progression. Recently, mounting evidence has demonstrated involvement of EMT in antagonizing chemotherapy in breast cancer. Here, we discuss the biological significance and clinical implications of these findings, with an emphasis on novel approaches that effectively target EMT to increase the efficacy of anticancer therapies.

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Differential sensitivity of colorectal cancer cell lines to artesunate is associated with expression of beta-catenin and E-cadherin

Cited by 38 publications

References 31 publications

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

Anticancer activity of botanical compounds in ancient fermented beverages (Review)

Epithelial-mesenchymal transition and drug resistance in breast cancer (Review)

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