Differential sensitivity to acute administration of cocaine, GBR 12909, and fluoxetine in mice selectively bred for hyperactive wheel-running behavior

Rhodes, Justin S.; Hosack, G. R.; Girard, Isabelle; Kelley, Ann E.; Mitchell, G. S.; Garland, Theodore

doi:10.1007/s002130100857

Cited by 92 publications

(22 citation statements)

References 63 publications

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“…1). For home-cage activity, the difference was 2.66-fold, which bolsters the use of these lines as a generalizable model for high activity levels or ''hyperactivity'' (see also Rhodes et al 2001Rhodes et al , 2005Malisch et al 2008). How the activity levels of HR mice compare with those of other strains that exhibit increased locomotor or exploratory behavior is not yet known.…”

Section: Discussionmentioning

confidence: 91%

Behavioral Despair and Home-Cage Activity in Mice with Chronically Elevated Baseline Corticosterone Concentrations

et al. 2008

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Dysfunction of the hypothalamic-pituitary-adrenal axis resulting in elevated baseline glucocorticoid concentrations is a hallmark of stress-related human anxiety and affective disorders, including depression. Mice from four replicate lines bred for high voluntary wheel running (HR lines) run almost three times as much as four non-selected control (C) lines, and exhibit two fold elevated baseline circulating corticosterone levels throughout the 24 h cycle. Although elevated baseline CORT may be beneficial for high locomotor activity, chronic elevations can have deleterious effects on multiple systems, and may predispose for affective disorders. Because stressful events often precede a depressive bout, we quantified depressive-like behavior in the forced-swim (FST; generation 41) and tail-suspension tests (TST; generation 47) in HR and C mice that had wheel access for 6 days and then were deprived of wheels on day seven prior to the FST or TST. Male HR spent significantly more time immobile in the FST than C, suggesting that HR males have a predisposition for depression-like behavior. Both male and female HR (generation 43) were more active than same-sex controls in both wheel running and home-cage activity across 22 h (pooling the sexes, HR/C = 2.28 and 2.66, respectively).

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Section: Discussionmentioning

confidence: 91%

Behavioral Despair and Home-Cage Activity in Mice with Chronically Elevated Baseline Corticosterone Concentrations

et al. 2008

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“…Therefore, leptin levels may have been affected by maternal WD before adult wheel access, but been returned to “baseline” values due to exercise-related fat loss. Alternatively, the lack of effect of maternal WD might be a common outcome, as a review of rat studies with maternal high-fat diet reported that 4 of 8 studies did not find significant effects on plasma leptin levels [60]. …”

Section: Discussionmentioning

confidence: 99%

Maternal exposure to Western diet affects adult body composition and voluntary wheel running in a genotype-specific manner in mice

Hiramatsu

Kay

Thompson

et al. 2017

Physiology & Behavior

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Some human diseases, including obesity, Type II diabetes, and numerous cancers, are thought to be influenced by environments experienced in early life, including in utero. Maternal diet during the perinatal period may be especially important for adult offspring energy balance, potentially affecting both body composition and physical activity. This effect may be mediated by the genetic background of individuals, including, for example, potential “protective” mechanisms for individuals with inherently high levels of physical activity or high basal metabolic rates. To examine some of the genetic and environmental factors that influence adult activity levels, we used an ongoing selection experiment with 4 replicate lines of mice bred for high voluntary wheel running (HR) and 4 replicate, non-selected control lines (C). Dams (half HR and half C) were fed a “Western” diet (WD, high in fat and sucrose) or a standard diet (SD) from 2 weeks prior to mating until their pups could feed on solid food (14 days of age). We analyzed dam and litter characteristics from birth to weaning, and offspring mass and physical activity. One male offspring from each litter received additional metabolic and behavioral tests. Maternal WD caused pups to eat solid food significantly earlier for C litters, but not for HR litters (interaction of maternal environment and genotype). With dam mass as a covariate, mean pup mass was increased by maternal WD but litter size was unaffected. HR dams had larger litters and tended to have smaller pups than C dams. Home-cage activity of juvenile focal males was increased by maternal WD. Juvenile lean mass, fat mass, and fat percent were also increased by maternal WD, but food consumption (with body mass as a covariate) was unaffected (measured only for focal males). Behavior in an elevated plus maze, often used to indicate anxiety, was unaffected by maternal WD. Maximal aerobic capacity (VO2max) was also unaffected by maternal WD, but HR had higher VO2max than C mice. Adult lean, fat, and total body masses were significantly increased by maternal WD, with greater increase for fat than for lean mass. Overall, no aspect of adult wheel running (total distance, duration, average running speed, maximum speed) or home-cage activity was statistically affected by maternal WD. However, analysis of the 8 individual lines revealed that maternal WD significantly increased wheel running in one of the 4 HR lines. On average, all groups lost fat mass after 6 days of voluntary wheel running, but the absolute amount lost was greater for mice with maternal WD resulting in no effect of maternal WD on absolute or % body fat after wheel access. All groups gained lean and total body mass during wheel access, regardless of maternal WD or linetype. Measured after wheel access, circulating leptin, adiponectin, and corticosterone concentrations were unaffected by maternal WD and did not differ between HR and C mice. With body mass as a covariate, heart ventricle mass was increased by maternal WD in both HR and C mice, but fat pad...

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“…Brown et al (2015) conducted the first investigation that used naïve HVR and LVR rat strains to determine if the motoric effects of cocaine in Larson and Carroll (2005) were genetically mediated. In this study, they found that LVR rats showed relatively greater cocaine-induced locomotor activity compared to HVR rats (see also Rhodes et al, 2001). Although LVRs were more sensitive than HVRs to the locomotor stimulating effects of cocaine, such motoric effects are not a reliable predictor of cocaine self-administration (Mitchell et al, 2005).…”

Section: Introductionmentioning

confidence: 54%

Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running

Smethells

Zlebnik

Miller

et al. 2016

Drug and Alcohol Dependence

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Background Previous research has found that rats behaviorally screened for high (vs. low) wheel running were more vulnerable to cocaine abuse. To assess the extent to which a genetic component is involved in this drug-abuse vulnerability, rats selectively bred for high or low voluntary running (HVR or LVR, respectively) were examined for differences in cocaine seeking in the present study. Methods Female rats were trained to lever press for food and then were assessed for differences in acquisition of cocaine (0.4 mg/kg; i.v.) self-administration across 10 sessions. Once acquired, rats self-administered cocaine for a 14-day maintenance phase, followed by a 14-day extinction phase when cocaine was no longer available. Subsequently, reinstatement of cocaine seeking was examined with priming injections of cocaine (5, 10 & 15 mg/kg), caffeine (30 mg/kg), yohimbine (2.5 mg/kg) and cocaine-paired cues. Results A greater percentage of LVR rats met the acquisition criteria for cocaine self-administration and in fewer sessions than HVR rats. No differences in responding for cocaine were observed between phenotypes during maintenance. However, during extinction LVR rats initially responded at higher rates and persisted in cocaine seeking for a greater number of sessions. No phenotype differences were observed following drug and cue-primed reinstatement of cocaine seeking. Conclusions In general, LVR rats were more sensitive to the reinforcing effects of cocaine than HVR rats during periods of transition into and out of cocaine self-administration. Thus, LVR rats showed a greater vulnerability cocaine seeking than HVR rats.

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Differential sensitivity to acute administration of cocaine, GBR 12909, and fluoxetine in mice selectively bred for hyperactive wheel-running behavior

Abstract: These results suggest an association between genetically determined hyperactive wheel-running behavior and dysfunction in the dopaminergic neuromodulatory system. Our selected lines may prove to be a useful genetic model for attention deficit hyperactivity disorder.

Cited by 92 publications

References 63 publications

Behavioral Despair and Home-Cage Activity in Mice with Chronically Elevated Baseline Corticosterone Concentrations

Behavioral Despair and Home-Cage Activity in Mice with Chronically Elevated Baseline Corticosterone Concentrations

Maternal exposure to Western diet affects adult body composition and voluntary wheel running in a genotype-specific manner in mice

Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running

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