Differential Size Distribution of A trial Dense Granules in Spontaneously Hypertensive, Wistar-Kyoto and Wistar Rats

Stein, Brenda; Katzeff, I.E.; Norton, G.; Wet, G de; Rosendorff, Clive

doi:10.1159/000146904

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…These observations suggest that factors other than weight determine the incidence, size, and volume density of the granules. This assumption is supported by the observation of smaller granules in atrial cells of spontaneously hypertensive rats compared with those of normotensive ones (Stein et al, 1990). Indeed, in hypertensive animals, atrial granule concentration is decreased while the plasma level of the hormone (atrial natriuretic factor; ANF) is increased (see Cantin and Genest, 1987).…”

Section: Discussionmentioning

confidence: 90%

“…It is well known also that ASGs contain both the propolypeptide and the biologically active atrial natriuretic factor (Cantin et al, 1984;Skepper and Navaratnam, 1988 according to Stein et al (1990), probably occurs in higher concentrations in the small type of ASG, which are predominant in the region of the Golgi apparatus (Jamieson and Palade, 1964). If this is so, it would support our thesis that the granules do not affect the tubular system significantly in bats, since irrespective of their location, the granules are generally small.…”

Section: Discussionmentioning

confidence: 99%

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Comparative ultrastructural morphometric analysis of atrial specific granules in the bat, mouse, and rat

1993

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Size, incidence, and volume density of atrial specific granules (ASG) in right atrial cells from five animals each of the rat (average weight 210 g), mouse (average weight 28 g), fruit-eating bat Megaloglossus woermanni (BMW; average weight 35 g), and the insect-eating bat Pipistrellus pipistrellus (BPP; average weight 6 g) have been compared via ultrastructural morphometry. In all three parameters of granule measurement, significantly higher figures were obtained in the rodents than in the bats. However, between the rat and the mouse, as also between the two species of bats, no significant differences were noted in any of the measurements. These results therefore do not support the prevalent view that the number and size of the granules decrease with increase in size of the animal species. The low content of ASG in atrial cells of the bats is probably an indication of low demand for the natriuretic hormone of the granule, because, in such animals, and particularly in flight, conservation of fluid and electrolytes is of paramount importance. This suggests that granule content is adapted to fluid and electrolyte regulation in relation to the functional capacity of the animal. We also observed ASG-like structures in endothelial cells of capillaries of bat tissue but not in rodents. The function of these granules or whether or not they represent atrial specific ones is not clear from the present study.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Comparative ultrastructural morphometric analysis of atrial specific granules in the bat, mouse, and rat

1993

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“…Biochemically, plasma ANP concentration and cellular ANP mRNA level decrease during dehydration [24,27]. Besides, ANP-granules become smaller during rapid synthesis especially in spontaneously hypertensive rats [26]. In our previous reports, the enhancement of ANP synthesis in the cells reduced the granule size [16], or ANP-granules became smaller with a concomitant decrease in the levels of atrial ANP mRNA and plasma ANP in the course the down-regulation [141.…”

Section: Discussionmentioning

confidence: 99%

Fine Structure of Atrial Natriuretic Peptide (ANP) -granules in the Atrial Cardiocytes in the Hamster, Guinea Pig, Rabbit, Cat and Dog

Mifune

Suzuki

Noda

et al. 1992

Experimental Animals

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“…Biochemically, plasma ANP concentration and cellular ANP mRNA level decrease during dehydration (25,29). Also, ANP-granules become smaller during rapid synthesis especially in spontaneously hypertensive rats (28). These findings indicate that ANP-granules become smaller as the ANP synthetic ability changes.…”

Section: Discussionmentioning

confidence: 83%

Atrial natriuretic peptide(ANP)-granules of the auricular cardiocytes in Syrian hamsters during the pre- and postnatal growth period.

Mifune

Suzuki

Noda

et al. 1991

Acta Histochem. Cytochem

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During pre-and postnatal development, the atrial natriuretic peptide (ANP)-granules in the right and left auricular cardiocytes of Syrian hamsters were studied immunohistochemically and by transmission electron microscopy. Moreover, the number and diameter of ANP-granules in the cardiocytes were analyzed by ultrastructural morphometry. Immunohistochemically, the ANP immunoreactivity was located primarily in the perinuclear region in auricular cardiocytes of the neonatal group, but was located diffusely in the cells of the fetal group. At the 15th day of gestation, the immunoreactivity was stronger than at the 13th day of gestation. The ANP immunoreactivity observed in the cardiocytes of the newborn was weaker than in the fetal group. During the postnatal growth period, the immunoreactivity became gradually stronger. Ultrastructurally, ANP-granules in the fetal cardiocytes were scattered in the cytoplasm with immature organelles. During the postnatal growth period, the granules were predominantly located in the perinuclear region associated with the Golgi apparatus.By ultrastructural morphometry, the number of granules in the right auricular cardiocytes was significantly greater than in the left auricular cardiocytes in all groups examined. In the newborn, the number of granules was significantly less than that in the fetal group. During the postnatal growth period, the granule number of cardiocytes significantly increased. There was no significant difference between the granule number of 10-day-old neonates and of 90-day-old neonates. During the postnatal period, the granule diameter in both auricles was significantly greater than in the fetal group. The granule size was not significantly different between the right auricular cardiocytes and the left ones in all groups examined. It is suggested that a large amount of ANP-granules is secreted at the perinatal period, resulting in granule depletion in both auricular cardiocytes.

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Differential Size Distribution of A trial Dense Granules in Spontaneously Hypertensive, Wistar-Kyoto and Wistar Rats

Cited by 9 publications

References 7 publications

Comparative ultrastructural morphometric analysis of atrial specific granules in the bat, mouse, and rat

Comparative ultrastructural morphometric analysis of atrial specific granules in the bat, mouse, and rat

Fine Structure of Atrial Natriuretic Peptide (ANP) -granules in the Atrial Cardiocytes in the Hamster, Guinea Pig, Rabbit, Cat and Dog

Atrial natriuretic peptide(ANP)-granules of the auricular cardiocytes in Syrian hamsters during the pre- and postnatal growth period.

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