Differential status and significance of non-enzymatic antioxidants (reactive oxygen species scavengers) in malaria and dengue patients

Aqeel, Sana; Naheda, Ansari; Raza, Adil; Khan, Kamran A.; Khan, Wajihullah

doi:10.1016/j.actatropica.2019.04.033

Cited by 12 publications

(21 citation statements)

References 45 publications

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“…The use of antioxidant compounds in the treatment of tropical diseases has increased, including Chagas disease, dengue, and malaria, as several studies have suggested the involvement of oxidative stress in the pathogenesis and progression of these diseases [54,258,259]. In this context, studies show that the discovery of new antimalarial drugs is necessary, and natural antioxidant products are important sources for obtaining new antimalarial compounds or even as adjuvant therapy, enhancing the activity of antimalarial drugs [260][261][262][263][264].…”

Section: Effects Of Lycopene On Malariamentioning

confidence: 99%

Potential Benefits of Lycopene Consumption: Rationale for Using It as an Adjuvant Treatment for Malaria Patients and in Several Diseases

et al. 2022

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Malaria is a disease that affects thousands of people around the world every year. Its pathogenesis is associated with the production of reactive oxygen and nitrogen species (RONS) and lower levels of micronutrients and antioxidants. Patients under drug treatment have high levels of oxidative stress biomarkers in the body tissues, which limits the use of these drugs. Therefore, several studies have suggested that RONS inhibition may represent an adjuvant therapeutic strategy in the treatment of these patients by increasing the antioxidant capacity of the host. In this sense, supplementation with antioxidant compounds such as zinc, selenium, and vitamins A, C, and E has been suggested as part of the treatment. Among dietary antioxidants, lycopene is the most powerful antioxidant among the main carotenoids. This review aimed to describe the main mechanisms inducing oxidative stress during malaria, highlighting the production of RONS as a defense mechanism against the infection induced by the ischemia-reperfusion syndrome, the metabolism of the parasite, and the metabolism of antimalarial drugs. Furthermore, the effects of lycopene on several diseases in which oxidative stress is implicated as a cause are outlined, providing information about its mechanism of action, and providing an evidence-based justification for its supplementation in malaria.

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Section: Effects Of Lycopene On Malariamentioning

confidence: 99%

Potential Benefits of Lycopene Consumption: Rationale for Using It as an Adjuvant Treatment for Malaria Patients and in Several Diseases

et al. 2022

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“…This led to the exclusion of 317 records for various reasons, including being in vitro/in vivo studies, review articles, or conference abstracts, as well as lacking GSH information, the absence of malaria cases, not specifying GSH type, or analyzing post-treatment GSH levels. Eventually, 18 studies meeting the criteria were included in the review 14 – 20 , 31 – 41 : 12 from the primary database search 15 – 17 , 20 , 31 – 37 , 39 , five from Google Scholar 14 , 18 , 19 , 38 , 41 , and one from a reference list 40 (Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysis

Kotepui,

Mahittikorn

et al. 2023

Sci Rep

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Reduced glutathione (GSH) is a crucial antioxidant with recognized roles in malaria pathogenesis and host response. Despite its importance, reports on the association of GSH with malaria are inconsistent. Therefore, this systematic review and meta-analysis investigated the differences in GSH levels in relation to Plasmodium infection. A comprehensive literature search of six electronic databases (Embase, MEDLINE, Ovid, PubMed, Scopus, and ProQuest) was conducted. Of the 2158 initially identified records, 18 met the eligibility criteria. The majority of studies reported a significant decrease in GSH levels in malaria patients compared with uninfected controls, and this was confirmed by meta-analysis (P < 0.01, Hedges g: − 1.47, 95% confidence interval [CI] − 2.48 to − 0.46, I2: 99.12%, 17 studies). Additionally, there was no significant difference in GSH levels between Plasmodium falciparum malaria and P. vivax malaria (P = 0.80, Hedges g: 0.11, 95% CI − 0.76 to 0.98, I2: 93.23%, three studies). Similarly, no significant variation was observed between symptomatic and asymptomatic malaria cases (P = 0.78, Hedges g: 0.06, 95% CI − 0.34 to 0.46, I2: 48.07%, two studies). In conclusion, although GSH levels appear to be generally lower in malaria patients, further detailed studies are necessary to fully elucidate this complex relationship.

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“…The glutathione cycle is associated with the antioxidant metabolites and constitutes one of the core systems for preventing the adverse reaction of free radicals. Under physiological state, free radicals and other ROS namely, superoxide radicals, hydroxyl radicals and hydrogen peroxides are generated during normal metabolic processes and performs bene cial role in the body, however at elevated concentration can lead to oxidative damage and several comorbidities of chronic in ammatory and immune system dysregulation most especially during Plasmodium parasite infection in animal and clinical trial (Aqeel et al, 2019). Interestingly, the combination of black seed supplemented diet and chloroquine (CQ) caused a notable suppression of free radicals production via the elevation of antioxidant enzyme, glutathione peroxidase (Gpx) in the plasma and liver of P.berghei infected mice.…”

Section: Discussionmentioning

confidence: 99%

Effect of black seeds ( Nigella sativa ) on inflammatory and immunomodulatory markers in Plasmodium berghei ‐infected mice

Ojueromi

Oboh

Ademosun

2022

Journal of Food Biochemistry

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N.sativa, a core dietary supplement and food additive in folklore is one of the most broadly studied seed plants in the global nutraceutical sector. Malaria infection impairs the ability of principal cells of the immune system to trigger an e cient in ammatory and immune response. Ninety-six mice weighing (20-25g) were grouped into twelve consisting of eight animals each. The mice were infected with standard inoculum of the strain NK65 P.berghei (chloroquine sensitive) and the percentage parasitemia suppression were evaluated. The individual effect of black seed supplemented diet and its combinatory effect with chloroquine (CQ) were investigated on the glutathione peroxidase(GPx), reduced glutathione(GSH), glutathione-S-transferase (GST), serum immunoglobulins (IgG and IgM), and the hematological parameters (haemoglobin, packed cell volume and red blood cell count) in P.berghei infected mice. The in ammatory cytokines; Tumor necrosis factor (TNF-α), C-reactive protein (CRP), Interleukin (IL-6 and IL-10) as well as IgG and IgM were assayed in the serum. The mice temperature and behavioural changes were observed. Infected mice treated with the dietary supplementation of black seed with a percentage inclusion (2.5%, 5% and 10%) showed signi cantly decreased parasitemia levels (p<0.05) compared with the untreated mice. The result demonstrated a signi cant suppression in the proin ammatory cytokines (TNF-α, CRP, IL-6) levels and a notable elevation in the anti-in ammatory cytokine (IL-10), antioxidant markers as well as the immunoglobulin levels of the P.berghei-infected mice treated with black seed. The study revealed that black seed enhanced host antioxidant status, modulated in ammatory and immune response by regulating some in ammatory cytokines and immunomodulatory mediators. Pratical ApplicationBlack seed (N.sativa) has been a dietary supplement and natural remedy for many ailments for many centuries. In ammatory and immune diseases are the most notable cause of mortality in the world and more than fty percent of deaths have been attributed to it. However, there's paucity of information on the effect of N.sativa on anti-in ammatory and immunomodulatory ability of N.sativa. The result suggests that N.sativa induced antioxidant, anti-in ammatory and immunomodulatory effect in P.bergheiinfected mice via the participation of glutathione antioxidant system, serum antibodies and some in ammatory cytokines.2.7 Grouping of Experimental Animals. Group 1: Normal control (Mice fed with basal diet) Group 2: Plasmodium berghei-infected mice (PBIM) Group 3: PBIM + chloroquine (CQ) (10 mg/kg)

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Differential status and significance of non-enzymatic antioxidants (reactive oxygen species scavengers) in malaria and dengue patients

Cited by 12 publications

References 45 publications

Potential Benefits of Lycopene Consumption: Rationale for Using It as an Adjuvant Treatment for Malaria Patients and in Several Diseases

Potential Benefits of Lycopene Consumption: Rationale for Using It as an Adjuvant Treatment for Malaria Patients and in Several Diseases

Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysis

Effect of black seeds ( Nigella sativa ) on inflammatory and immunomodulatory markers in Plasmodium berghei ‐infected mice

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