Differential Striatal Dopamine Responses Following Oral Alcohol in Individuals at Varying Risk for Dependence

Setiawan, Elaine; Pihl, Robert O.; Dagher, Alain; Schlagintweit, Hera E.; Casey, Kevin F.; Benkelfat, Chawki; Leyton, Marco

doi:10.1111/acer.12218

Cited by 39 publications

(45 citation statements)

References 52 publications

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“…This accords with our previous finding that beer flavor alone increased right NAcc DA in a similar population of heavy drinkers (Oberlin et al , 2013), and that (unexpected) intravenous ethanol intoxication increased left VST DA (Yoder et al , 2009). Previous reports showed bilateral VST DA increases resulting from ethanol CS and US presented together (Boileau et al , 2003; Setiawan et al , 2014; Urban et al , 2010), although in these studies, fruit juice was the tastant (not necessarily the preferred mixer), meaning that ethanol’s orosensory properties could have acted as a CS. If we regard these previous studies as concomitant alcohol CS and US presentation, these data comport with our current findings of bilateral NAcc DA release to combined alcohol CS and US presentation.…”

Section: Discussionmentioning

confidence: 70%

“…Other studies found no effect with IV alcohol (Yoder et al , 2007; Yoder et al , 2005), or found it only when alcohol was unexpected (Yoder et al , 2009). However, two RAC-PET studies reported bilateral VST DA release when social drinkers consumed alcoholic beverages orally, thus combining alcohol’s intraoral somatosensory CS effects with the US of intoxication (Boileau et al , 2003; Urban et al , 2010); a similar study of oral consumption reported bilateral VST DA release, but only in high-risk subjects (Setiawan et al , 2014). …”

Section: Introductionmentioning

confidence: 99%

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Beer self-administration provokes lateralized nucleus accumbens dopamine release in male heavy drinkers

et al. 2014

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Rationale Although striatal dopamine (DA) is important in alcohol abuse, the nature of DA release during actual alcohol drinking is unclear, since drinking includes self-administration of both conditioned flavor stimuli (CS) of the alcoholic beverage and subsequent intoxication, the unconditioned stimulus (US). Objectives Here we used a novel self-administration analog to distinguish nucleus accumbens (NAcc) DA responses specific to the CS and US. Methods Right-handed male heavy drinkers (n=26) received 3 positron emission tomography (PET) scans with the D2/D3 radioligand [11C]raclopride (RAC), and performed a pseudo self-administration task that separately administered a flavor CS of either a habitually consumed beer or the appetitive control Gatorade®, concomitant with the US of ethanol intoxication (0.06 g/dL IV administration) or IV saline. Scan conditions were Gatorade flavor + saline (Gat&Sal); Gatorade flavor + ethanol (Gat&Eth); and beer flavor + ethanol (Beer&Eth). Results Ethanol (US) reduced RAC binding (inferring DA release) in the left (L) NAcc [Gat&Sal > Gat&Eth]. Beer flavor (CS) increased DA in the right (R) NAcc [Gat&Eth > Beer&Eth]. The combination of beer flavor and ethanol (CS + US), [Gat&Sal > Beer&Eth], induced DA release in bilateral NAcc. Self-reported intoxication during scanning correlated with L NAcc DA release. Relative to saline, infusion of ethanol increased alcoholic drink wanting. Conclusions Our findings suggest lateralized DA function in the NAcc, with L NAcc DA release most reflecting intoxication, R NAcc DA release most reflecting the flavor CS, and the conjoint CS+US producing a bilateral NAcc response.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Beer self-administration provokes lateralized nucleus accumbens dopamine release in male heavy drinkers

et al. 2014

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“…First, a distinctively high dopamine response was seen in impulsive substance users at elevated risk for addictions, as compared to low risk users, when they were tested with drug cues present (alcohol ingested with the beverage’s sight, smell, taste and touch) [120]. Second, and in striking contrast, exceptionally low dopamine release was observed in impulsive substance users at elevated risk for addictions when they were tested without drug cues present ( d -amphetamine tablets hidden in nondescript gelcaps) [114].…”

Section: Hyper- and Hypo-dopamine Activity Following The Initiation Omentioning

confidence: 99%

Dopamine ups and downs in vulnerability to addictions: a neurodevelopmental model

Leyton

Vezina

2014

Trends in Pharmacological Sciences

Self Cite

120

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Addictions are commonly presaged by problems in childhood and adolescence. For many individuals this starts with the early expression of impulsive risk-taking, social gregariousness and oppositional behaviors. We propose here that these early diverse manifestations reflect a heightened ability of emotionally salient stimuli to activate dopamine pathways that foster behavioral approach. If substance use is initiated, these at-risk youth can also develop heightened responses to drug-paired cues. Through conditioning and drug-induced sensitization, these effects strengthen and accumulate, leading to responses that exceed those elicited by other rewards. At the same time, cues not paired with drug become associated with comparatively lower dopamine release, accentuating further the difference between drug and non-drug rewards. Together, these enhancing and inhibiting processes steer a pre-existing vulnerability toward a disproportionate concern for drugs and drug-related stimuli. Implications for prevention and treatment are discussed.

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“…Some have been pointed out as addiction biomarkers or endophenotypes: working memory, behavioral inhibition (Iacono, Malone & McGue, 2008), error processing (Euser, Evans, Greaves-Lord, Huizink & Franken, 2013), anxiety-impulsivity traits like delayed reward discounting (MacKillop, 2013) and even subjective responses to alcohol (Setiawan et al, 2014). Neuroanatomical correlates of these predisposing factors have been described (Wetherhill et al, 2012;Seigneurie, Guérin Langlois & Limosin, 2013).…”

Section: Alcohol-related Brain Damage From Categories To Dimensionsmentioning

confidence: 99%

Daño cerebral relacionado con el alcohol. Situación actual y llamada a la acción

Gonzalez¹,

Oliveró²

2014

Adicciones

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Differential Striatal Dopamine Responses Following Oral Alcohol in Individuals at Varying Risk for Dependence

Abstract: Changes in striatal DA in response to alcohol ingestion may be a neurobiological marker of vulnerability to AUDs.

Cited by 39 publications

References 52 publications

Beer self-administration provokes lateralized nucleus accumbens dopamine release in male heavy drinkers

Beer self-administration provokes lateralized nucleus accumbens dopamine release in male heavy drinkers

Dopamine ups and downs in vulnerability to addictions: a neurodevelopmental model

Daño cerebral relacionado con el alcohol. Situación actual y llamada a la acción

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