Differential study of DCE-MRI parameters in spinal metastatic tumors, brucellar spondylitis and spinal tuberculosis

Qiao, Peng-Fei; Zhao, Pengfei; Gao, Yang; Bai, Yang; Guang-ming, Niu

doi:10.21147/j.issn.1000-9604.2018.04.05

Cited by 14 publications

(11 citation statements)

References 14 publications

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“…This was consistent with previous reports that DCE-MRI indexes could predict tumor response to treatment and be used as a reliable method to follow up the changes of tumor blood vessel perfusion. 17,18 The Efficacy of Endostar Determined by Pathology…”

Section: Dovepressmentioning

confidence: 99%

<p>Endostar Rebuilding Vascular Homeostasis and Enhancing Chemotherapy Efficacy in Cervical Cancer Treatment</p>

Guan¹

2020

OTT

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Background The incidence rate of cervical cancer is the highest in the reproductive tract and is not sensitive to chemotherapy. An appropriate amount of anti-angiogenic agents can reconstruct tumor blood vessels in a short period of time and form vascular homeostasis, increase the function of blood vessel perfusion and reverse the multidrug resistance of chemotherapy, which is also called “vascular normalization.” Endostar (a recombinant human endostatin) was developed by China and as a multi-target anti-angiogenesis agent. Many reports about endostar involved the treatment of non-small cell lung cancer, fewer reports are on cervical cancer. Purpose To determine whether endostar can rebuild tumor vascular homeostasis and enhance chemotherapy effects for patients with cervical cancer. Methods In this study, the patients with cervical cancer within stage IIB2 were selected, endostar combined with cisplatin+paclitaxel neoadjuvant chemotherapy (NACT) before radical surgical operation was adopted, patients outcome and adverse reaction were followed up. The changes of tumor vascular structure and perfusion function before and after endostar given were evaluated by histopathology and dynamic contrast-enhanced magnetic resonance imaging (DEC-MRI). VEGF-Notch signal pathway was detected for the regulating mechanism of vascular proliferation in different groups. GraphPad Prism 6 software was used for statistical analysis of the study results. Results Endostar enhanced the short-term (2 year) overall survival (OS), progression-free survival (PFS) rates for cervical cancer patients. All the same, endostar increased long-term (5 year) OS for cervical cancer patients. Endostar therapy exhibited with mild adverse reaction. MRI showed endostar+NACT further reduce tumor volume than NACT alone. The parameters of Ktrans, Ve for DEC-MRI in endostar group exhibited obviously increase than NACT group. Tumor vascular maturation index α-SMA/CD31 in endostar group increased obviously than NACT group, correspondingly Ki67 staining for tumor proliferative rates, lymphovascular space invasion in endostar group further declined than NACT group. The genes and proteins expression of VEGFR2, Notch1, Notch 4 , Dll4 , Jag1 were obviously downregulated in endostar group comparing to NACT group. Conclusion Endostar restored vascular homeostasis in cervical cancer temporarily, enhanced chemotherapeutic agents effects in cervical cancer, increased patient OS ratio. Endostar+NACT treatment may provide a new target therapy for cervical cancer.

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Section: Dovepressmentioning

confidence: 99%

<p>Endostar Rebuilding Vascular Homeostasis and Enhancing Chemotherapy Efficacy in Cervical Cancer Treatment</p>

Guan¹

2020

OTT

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“…NACT can determine cervical cancer responsive to cisplatin+paclitaxel(PT) regimen. When DCE-MRI con rmed cervical cancer could not responsible well in this therapy,we adopted endostar+PT project to increase cytotoxic effects of chemotherapy and reduced its side effects [14,15].…”

Section: Treatment E Cacy Of Endostar Determined By Dce-mrimentioning

confidence: 99%

Endostar Rebuilding Vascular Homeostasis and Enhancing Chemotherapy Efficacy in Cervical Cancer Treatment

Guan¹

2020

Preprint

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Background: The incidence rate of cervical cancer is the highest in the reproductive tract, and is not sensitive to chemotherapy. An appropriate amount of antiangiogenic agents can reconstruct tumor blood vessels in a short period of time and form vascular homeostasis, increase the function of blood vessel perfusion and reverse the multidrug resistance of chemotherapy, which is also called "vascular normalization".Endostar(a recombinant human endostatin) was developed by China and as a multi-target anti-angiogenesis agent.Endostar was mainly used in the treatment of non-small cell lung cancer,less reported in the treatment of cervical cancer.Purpose: To determine whether endostar can rebuild tumor vascular homeostasis and enhance chemotherapy effects for patients with cervical cancer.Methods: In this study,the patients with cervical cancer were selected,endostar combined with cisplatin+paclitaxel neoadjuvant chemotherapy(NACT) before surgical operation was adopted, patients outcome and adverse reaction were followed up.The changes of tumor vascular structure and perfusion function before and after endostar given were evaluated by histopathology and dynamic contrast-enhanced magnetic resonance imaging(DEC-MRI). VEGF-Notch signal pathway was detected for the regulating mechanism of vascular proliferation in different groups. GraphPad Prism 6 software were used for statistical analysis of the study results.Results: Endostar enhanced short-term (2 year) overall survival(OS) ,progression free survival(PFS) rates for cervical cancer patients.All the same,endostar increased long term (5 year) OS and PFS for cervical cancer patients.Endostar therapy exhibited with mild adverse reaction.MRI showed endostar+NACT further reduce tumor volume than NACT alone.The parameters of Ktrans,Ve for DEC-MRI in endostar groups exhibited obviously increase than NACT groups.Tumor vascular maturation index α-SMA/CD31 in endostar groups increased obviously than that of NACT groups, correspondingly tumor proliferative rate Ki67 staining in endostar groups further declined than NACT groups.The genes and proteins expression of VEGFR2,Notch1,Notch1,4,Dll4,Jagged-1 were obviously down regulated in endostar group comparing to that of NACT group.Conclusions: Endorstar restored vascular homeostasis in cervical cancer temporarily, provided a new way to reverse chemotherapeutic agents resistance in cervical cancer, increased patient survival time.The VEGF-Notch connection was blocked by endostar playing a role in this effects.

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“…Metastatic cancer, spinal infection, and spinal tuberculosis are frequently seen in the clinic. The spine is easily affected by disease [1] , which can involve the vertebral bodies with or without involvement of intervertebral discs, posterior neural elements, and paraspinal soft tissues. Affected patients can present with similar symptoms, such as backache.…”

Section: Introductionmentioning

confidence: 99%

Role of magnetic resonance imaging in the differential diagnosis of spinal signal changes caused by infection and tumor in the early stages

Chen

et al. 2021

Preprint

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Background: Spinal infection and tumor have abnormal magnetic resonance imaging (MRI) manifestations in the early stages; however, they are not easy to identify before symptoms appear. These conditions have their own characteristics and need to be correctly diagnosed.Methods: MRI images of six cases of pyogenic spondylitis, eight cases of tuberculous spondylitis, eight cases of Brucella spondylitis, and twelve cases of spinal tumor were reviewed. MRI images of the involved vertebral body, vertebral facet joint, spinous process, paravertebral soft tissue, and posterior dural sac of the vertebral body were analyzed using T2-weighted imaging, T1-weighted imaging, lipgraphy and enhanced MRI, respectively. Results: MRI data of spinal infection, spinal tuberculosis, spinal tumor, and spinal Brucella infection differed in their characteristics.Conclusions: MRI could provide early diagnostic evidence for spinal lesions.

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Differential study of DCE-MRI parameters in spinal metastatic tumors, brucellar spondylitis and spinal tuberculosis

Cited by 14 publications

References 14 publications

<p>Endostar Rebuilding Vascular Homeostasis and Enhancing Chemotherapy Efficacy in Cervical Cancer Treatment</p>

<p>Endostar Rebuilding Vascular Homeostasis and Enhancing Chemotherapy Efficacy in Cervical Cancer Treatment</p>

Endostar Rebuilding Vascular Homeostasis and Enhancing Chemotherapy Efficacy in Cervical Cancer Treatment

Role of magnetic resonance imaging in the differential diagnosis of spinal signal changes caused by infection and tumor in the early stages

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