Differential Temporal Evolution Patterns in Brain Temperature in Different Ischemic Tissues in a Monkey Model of Middle Cerebral Artery Occlusion

Sun, Zhihua; Zhang, Jing; Chen, Yingmin; Zhang, Yunting; Zhang, Xuejun; Guo, Hong; Yu, Chunshui

doi:10.1155/2012/980961

Cited by 12 publications

(8 citation statements)

References 28 publications

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“…Temperature measured at the tip of the thermistor in situ and irrespective of brain site has been regarded as 'brain' temperature for the purposes of this systematic review but issues regarding the site of measurement and differences in temperature values at damaged versus undamaged sites could have a bearing on the brain temperature reading. As shown using magnetic resonance spectroscopic techniques for absolute temperature measurement [29] in experimental (non-human primate) stroke, highest values were observed in the ischaemic penumbra, values higher than in the contralateral (unaffected) region and ischaemic core [30]. Such findings suggest a potential explanation for the variations between study groups, possibly on the basis of evolution of the primary injury to infarction.…”

Section: Limitationsmentioning

confidence: 94%

Clinical review: Brain-body temperature differences in adults with severe traumatic brain injury

Childs

Lunn

2013

Crit Care

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Surrogate or 'proxy' measures of brain temperature are used in the routine management of patients with brain damage. The prevailing view is that the brain is 'hotter' than the body. The polarity and magnitude of temperature differences between brain and body, however, remains unclear after severe traumatic brain injury (TBI). The focus of this systematic review is on the adult patient admitted to intensive/neurocritical care with a diagnosis of severe TBI (Glasgow Coma Scale score of less than 8). The review considered studies that measured brain temperature and core body temperature. Articles published in English from the years 1980 to 2012 were searched in databases, CINAHL, PubMed, Scopus, Web of Science, Science Direct, Ovid SP, Mednar and ProQuest Dissertations & Theses Database. For the review, publications of randomised controlled trials, non-randomised controlled trials, before and after studies, cohort studies, case-control studies and descriptive studies were considered for inclusion. Of 2,391 records identified via the search strategies, 37 were retrieved for detailed examination (including two via hand searching). Fifteen were reviewed and assessed for methodological quality. Eleven studies were included in the systematic review providing 15 brain-core body temperature comparisons. The direction of mean brain-body temperature differences was positive (brain higher than body temperature) and negative (brain lower than body temperature). Hypothermia is associated with large brain-body temperature differences. Brain temperature cannot be predicted reliably from core body temperature. Concurrent monitoring of brain and body temperature is recommended in patients where risk of temperature-related neuronal damage is a cause for clinical concern and when deliberate induction of below-normal body temperature is instituted.

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Section: Limitationsmentioning

confidence: 94%

Clinical review: Brain-body temperature differences in adults with severe traumatic brain injury

Childs

Lunn

2013

Crit Care

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“…In previous years, different techniques were used for brain temperature measurement, invasively by inserting probes in brain tissue [47]. Invasive techniques may produce local microlesions and inflammatory responses nearby the probes, which might influence brain temperature [48]. Infrared thermal imaging (thermography) is a noninvasive technique, it has been used to measure brain temperature under the name of intraoperative thermal imaging (ITI) to delineate brain tumor borders [39,[49][50][51], and this technique is used during surgical resection of brain lesions.…”

Section: Discussionmentioning

confidence: 99%

Towards an Accurate MRI Acute Ischemic Stroke Lesion Segmentation Based on Bioheat Equation and U-Net Model

Bousselham

Bouattane

Youssfi

et al. 2022

International Journal of Biomedical Imaging

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Acute ischemic stroke represents a cerebrovascular disease, for which it is practical, albeit challenging to segment and differentiate infarct core from salvageable penumbra brain tissue. Ischemic stroke causes the variation of cerebral blood flow and heat generation due to metabolism. Therefore, the temperature is modified in the ischemic stroke region. In this paper, we incorporate acute ischemic stroke temperature profile to reinforce segmentation accuracy in MRI. Pennes bioheat equation was used to generate brain thermal images that may provide rich information regarding the temperature change in acute ischemic stroke lesions. The thermal images were generated by calculating the temperature of the brain with acute ischemic stroke. Then, U-Net was used in this paper for the segmentation of acute ischemic stroke. A dataset of 3192 images was created to train U-Net using k -fold crossvalidation. The training time was about 10 hours and 35 minutes in NVIDIA GPU. Next, the obtained trained model was compared with recent methods to analyze the effect of the ischemic stroke temperature profile in segmentation. The obtained results show that significant parts of acute ischemic stroke and background areas are segmented only in thermal images, which proves the importance of using thermal information to improve the segmentation outcomes in MRI diagnosis.

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“…In-vivo MRS temperature measurement has been reported using both single voxel methods ( 49 , 50 , 59 , 63 , 64 ) and spectroscopic imaging ( 65 – 68 ). A challenge for both types of methods is obtaining a good shim to make the magnetic field as uniform as possible and thus minimise the water and metabolite linewidths.…”

Section: Challenges For Mrs Temperature Measurementmentioning

confidence: 99%

Brain temperature monitoring in newborn infants: Current methodologies and prospects

et al. 2022

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Brain tissue temperature is a dynamic balance between heat generation from metabolism, passive loss of energy to the environment, and thermoregulatory processes such as perfusion. Perinatal brain injuries, particularly neonatal encephalopathy, and seizures, have a significant impact on the metabolic and haemodynamic state of the developing brain, and thereby likely induce changes in brain temperature. In healthy newborn brains, brain temperature is higher than the core temperature. Magnetic resonance spectroscopy (MRS) has been used as a viable, non-invasive tool to measure temperature in the newborn brain with a reported accuracy of up to 0.2 degrees Celcius and a precision of 0.3 degrees Celcius. This measurement is based on the separation of chemical shifts between the temperature-sensitive water peaks and temperature-insensitive singlet metabolite peaks. MRS thermometry requires transport to an MRI scanner and a lengthy single-point measurement. Optical monitoring, using near infrared spectroscopy (NIRS), offers an alternative which overcomes this limitation in its ability to monitor newborn brain tissue temperature continuously at the cot side in real-time. Near infrared spectroscopy uses linear temperature-dependent changes in water absorption spectra in the near infrared range to estimate the tissue temperature. This review focuses on the currently available methodologies and their viability for accurate measurement, the potential benefits of monitoring newborn brain temperature in the neonatal intensive care unit, and the important challenges that still need to be addressed.

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Differential Temporal Evolution Patterns in Brain Temperature in Different Ischemic Tissues in a Monkey Model of Middle Cerebral Artery Occlusion

Cited by 12 publications

References 28 publications

Clinical review: Brain-body temperature differences in adults with severe traumatic brain injury

Clinical review: Brain-body temperature differences in adults with severe traumatic brain injury

Towards an Accurate MRI Acute Ischemic Stroke Lesion Segmentation Based on Bioheat Equation and U-Net Model

Brain temperature monitoring in newborn infants: Current methodologies and prospects

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