Integral–algebraic equations and their systems are a common description of many technical and engineering problems. Often, such models also describe certain dependencies occurring in nature (e.g., ecosystem behaviors). The integral equations occurring in this problem may have two types of domains—symmetric or asymmetric. Depending on whether such symmetry exists in the system describing a given problem, we must choose the appropriate method to solve this system. In this task, the absence of symmetry is more advantageous, but the presented examples demonstrate how one can approach cases where symmetry is present. In this paper, we present the application of two methods for solving such tasks: the analytical Differential Transform Method (DTM) and Physics-informed Neural Networks (PINNs). We consider a wide class of these types of equation systems, including Volterra and Fredholm integrals (which are also in a single model). We demonstrate that despite the complex nature of the problem, both methods are capable of handling such tasks, and thus, they can be successfully applied to the issues discussed in this article.