Differential trends in rising endometrial cancer incidence by age, race, and ethnicity

Liu, Lihua; Habeshian, Talar S.; Zhang, Juanjuan; Peeri, Noah C; Du, Mengmeng; Vivo, Immaculata De; Setiawan, Veronica Wendy

doi:10.1093/jncics/pkad001

Cited by 31 publications

(17 citation statements)

References 15 publications

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“…Several studies have found a similar increase in the incidence of early-onset uterine cancer, particularly among non-Hispanic Black and Hispanic women. [12][13][14][15] Guo et al 15 reported a notable annual percent increase in uterine cancer in younger age groups between 2001 and 2017: 3.6% among 20-29-year-olds and 3% among 30-39-year-olds. This increase in early-onset uterine cancer is also seen in other obesity-related cancers, including colorectal, multiple myeloma, gallbladder, kidney, and pancreatic cancers.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, part of the cause of higher uterine cancer mortality rates among older non-Hispanic Black women and younger minority women could be attributed in part to the higher rates of obesity in these populations. [12][13][14][15]23 In 2017-2018, 39.8% of non-Hispanic White women, 43.7% of Hispanic women, 56.9% of non-Hispanic Black women, and 17.2% of non-Hispanic Asian or Pacific Islander women had obesity. 24 The higher levels of obesity seen among racial and ethnic minorities have been attributed to a wide variety of social and structural factors.…”

Section: Discussionmentioning

confidence: 99%

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Trends in Uterine Cancer Mortality in the United States

Somasegar,

Bashi,

Lang

et al. 2023

Obstetrics &Amp; Gynecology

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OBJECTIVE: To analyze mortality trends in uterine cancer in the United States over 50 years with an emphasis on age and race and ethnicity. METHODS: Data on uterine cancer deaths from 1969 to 2018 were obtained from the National Center for Health Statistics. Trends were examined by age and race and ethnicity after adjustment for the hysterectomy rate and pregnancy. RESULTS: Uterine cancer mortality decreased between 1969 and 1997 (from 6.03 to 4.00/100,000) but increased between 1997 and 2018 (from 4.00 to 5.02/100,000). From 2001 to 2018, mortality rates increased by 1.25-fold across all age groups. In 2018, the mortality rate from uterine cancer for patients aged 70 years or older and 60–69 years was sixfold and threefold higher, respectively, than in younger patients (aged 50–59 years) (54.87/100,000 vs 27.80/100,000 vs 8.70/100,000). The mortality rate for non-Hispanic Black women was 2.2-fold higher than for non-Hispanic White, Hispanic, and non-Hispanic Asian or Pacific Islander women (17.6/100,000 vs 7.82/100,000, 6.54/100,000, and 4.24/100,000, respectively). On an intersection analysis of age and race, non-Hispanic Black women aged older than 60 years had a threefold higher mortality rate than non-Hispanic White women (72/100,000 vs 24/100,000). A notable finding was that young non-Hispanic Black and Hispanic women (30–39 years) had the highest annual increases in mortality at 3.3% and 3.8% per year compared with 2.2% in non-Hispanic White women. CONCLUSION: Since 2001, the uterine cancer mortality rate has increased across all four racial and ethnic groups examined, with the highest increase seen among non-Hispanic Black women. The largest increase in mortality was observed among younger non-Hispanic Black and Hispanic women.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Trends in Uterine Cancer Mortality in the United States

Somasegar,

Bashi,

Lang

et al. 2023

Obstetrics &Amp; Gynecology

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“…5) considers proximal (individual, biologic), intermediate (social and physical environments), and distal structural factors to best explain causes of disparities and their interplay. 78…”

Section: Ovarian Cancer Health Equity In the United Statesmentioning

confidence: 99%

“…Increased annual percentage change (2007-2019) is higher for non-Hispanic minority patients (Black, 2.4%; Asian/Pacific Islander, 2.5%; American Indian/Alaska Native, 2.5%) and Hispanic patients (2.9%) compared with NHWs (0.7%). 78 Those EC cases diagnosed at age younger than 50 years (early onset) have also increased among Black, Hispanic, and non-Hispanic Asian Pacific Islander patients compared with NHW women. 79 Early-onset EC tends to be hormonally driven and may be partially driven by trends in increasing obesity.…”

Section: Disparities In the United Statesmentioning

confidence: 99%

“…Montes de Oca et al, 67 in their analysis, review measures of health care access dimensions to include “affordability (ability to pay), availability (service type, quality, volume), accessibility (geographic location), accommodation, and acceptability (quality of patient-provider interaction, patient experience).” An additional important framework (Fig. 5) considers proximal (individual, biologic), intermediate (social and physical environments), and distal structural factors to best explain causes of disparities and their interplay 78 …”

Section: Ovarian Cancermentioning

confidence: 99%

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Disparities in Gynecologic Cancers

Lee,

Tiro,

Odunsi

2023

Cancer J

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Gynecologic cancer disparities have different trends by cancer type and by sociodemographic/economic factors. We highlight disparities in the United States arising due to poor delivery of cancer care across the continuum from primary prevention, detection, and diagnosis through treatment and identify opportunities to eliminate/reduce disparities to achieve cancer health equity. Our review documents the persistent racial and ethnic disparities in cervical, ovarian, and uterine cancer outcomes, with Black patients experiencing the worst outcomes, and notes literature investigating social determinants of health, particularly access to care. Although timely delivery of screening and diagnostic evaluation is of paramount importance for cervical cancer, efforts for ovarian and uterine cancer need to focus on timely recognition of symptoms, diagnostic evaluation, and delivery of guideline-concordant cancer treatment, including tumor biomarker and somatic/germline genetic testing.

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Patterns in Cancer Incidence Among People Younger Than 50 Years in the US, 2010 to 2019

Koh

Tan

et al. 2023

JAMA Netw Open

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ImportanceEmerging data suggest that the incidence of early-onset cancers, defined as cancers diagnosed in people younger than 50 years, is increasing, but updated data are limited.ObjectiveTo characterize the patterns in the incidence of early-onset cancers in the US from 2010 to 2019 and provide granular data on the cancers with the fastest-growing incidence rates.Design, Setting, and ParticipantsThis population-based cohort study analyzed data from 17 National Cancer Institute Surveillance, Epidemiology, and End Results registries from January 1, 2010, to December 31, 2019. Age-standardized incidence rates per 100 000 people were extracted for early-onset cancers, with rates age adjusted to the US standard population. A total of 562 145 patients with early-onset cancer between 2010 and 2019 were identified and included. Data were analyzed from October 16, 2022, to May 23, 2023.Main Outcomes and MeasuresPrimary outcomes were incidence rates and descriptive epidemiological data for people younger than 50 years with cancer. The annual percentage change (APC) of the age-standardized incidence rate was estimated using the Joinpoint regression program.ResultsAmong 562 145 patients (324 138 [57.7%] aged 40-49 years; 351 120 [62.5%] female) with early-onset cancer, 4565 (0.8%) were American Indian or Alaska Native, 54 876 (9.8%) were Asian or Pacific Islander, 61 048 (10.9%) were Black, 118 099 (21.0%) were Hispanic, 314 610 (56.0%) were White, and 8947 (1.6%) were of unknown race and/or ethnicity. From 2010 to 2019, the age-standardized incidence rate of early-onset cancers increased overall (APC, 0.28%; 95% CI, 0.09%-0.47%; P = .01) and in female individuals (APC, 0.67%; 95% CI, 0.39%-0.94%; P = .001) but decreased in male individuals (APC, −0.37%; 95% CI, −0.51% to −0.22%; P &lt; .001). In contrast, the age-standardized incidence rate of cancers in individuals aged 50 years and older decreased over the study period (APC, −0.87%; 95% CI, −1.06% to −0.67%; P &lt; .001). In 2019, the highest number of incident cases of early-onset cancer were in the breast (n = 12 649). From 2010 to 2019, gastrointestinal cancers had the fastest-growing incidence rates among all early-onset cancer groups (APC, 2.16%; 95% CI, 1.66%-2.67%; P &lt; .001). Among gastrointestinal cancers, those with the fastest-growing incidence rates were in the appendix (APC, 15.61%; 95% CI, 9.21%-22.38%; P &lt; .001), intrahepatic bile duct (APC, 8.12%; 95% CI, 4.94%-11.39%; P &lt; .001), and pancreas (APC, 2.53%; 95% CI, 1.69%-3.38%; P &lt; .001).Conclusions and RelevanceIn this cohort study, the incidence rates of early-onset cancer increased from 2010 to 2019. Although breast cancer had the highest number of incident cases, gastrointestinal cancers had the fastest-growing incidence rates among all early-onset cancers. These data may be useful for the development of surveillance strategies and funding priorities.

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Differential trends in rising endometrial cancer incidence by age, race, and ethnicity

Cited by 31 publications

References 15 publications

Trends in Uterine Cancer Mortality in the United States

Trends in Uterine Cancer Mortality in the United States

Disparities in Gynecologic Cancers

Patterns in Cancer Incidence Among People Younger Than 50 Years in the US, 2010 to 2019

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