Differential Vector Competency of Aedes albopictus Populations from the Americas for Zika Virus

Azar, Sasha R.; Roundy, Christopher M.; Rossi, Shannan L.; Huang, Jing; Leal, Grace; Yun, Ruimei; Fernández‐Salas, Ildefonso; Vitek, Christopher J.; Paploski, Igor Adolfo Dexheimer; Stark, Pamela M.; Vela, Jeremy; Debboun, Mustapha; Reyna, Martin; Kitron, Uriel; Ribeiro, Guilherme S.; Hanley, Kathryn A.; Vasilakis, Nikos; Weaver, Scott C.

doi:10.4269/ajtmh.16-0969

Cited by 82 publications

(99 citation statements)

References 57 publications

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“…However, recent in vivo and in vitro experimental work using a limited number of ZIKV strains demonstrated that the African lineage exhibits increased fitness/virulence in vertebrates as well as mosquito vectors compared to Asian lineage strains (Bowen et al, 2017; Weger-Lucarelli et al, 2016; Lazear et al, 2016; Roundy et al, 2017; Azar et al, 2017). Characterization of additional African strains in mosquito vectors, reservoir hosts and models for human infection, including early African isolates not available in reference collections are needed to fully explore the evolution of ZIKV, as well as to identify mutations potentially associated with differing phenotypes.…”

Section: Emergence and Spread Of Zikv Infectionmentioning

confidence: 99%

“…aegypti mosquito (Marchette et al, 1969; Weger-Lucarelli et al, 2016; Roundy et al, 2017; Olson et al, 1981; Guerbois et al, 2016; Li et al, 2012; Boorman and Porterfield, 1956; Cornet et al, 1979b; Hall-Mendelin et al, 2016; Richard et al, 2016; Chouin-Carneiro et al, 2016), and to lesser degree the peridomestic Ae. albopictus (Azar et al, 2017; Grard et al, 2014; Wong et al, 2013), Ae. hensilli (Ledermann et al, 2014) and Ae.…”

Section: Mosquito Transmission and Control Measures (Nikos Vasilakis)mentioning

confidence: 99%

“…aegypti . So, taking into consideration its similar vector competence (Azar et al, 2017), Ae. albopictus is expected to play a secondary role in regions inhabited by similar populations.…”

Section: Mosquito Transmission and Control Measures (Nikos Vasilakis)mentioning

confidence: 99%

“…aegypti mosquitoes, or for higher viremia in humans, which could enhance fetal infection. To date, most experimental studies (Weger-Lucarelli et al, 2016; Roundy et al, 2017; Azar et al, 2017) have failed to support these hypotheses, and cases of microcephaly possibly associated with maternal ZIKV infection in Thailand, Vietnam and Guinea Bissau (Gulland, 2016) suggest that Asian and African ZIKV strains may be capable of producing CZS. However, a recent study reported that NS1 antigen levels affect ZIKV oral infectivity of Ae.…”

Section: Mosquito Transmission and Control Measures (Nikos Vasilakis)mentioning

confidence: 99%

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Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

et al. 2017

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In response to the outbreak of Zika virus (ZIKV) infection in the Western Hemisphere and the recognition of a causal association with fetal malformations, the Global Virus Network (GVN) assembled an international taskforce of virologists to promote basic research, recommend public health measures and encourage the rapid development of vaccines, antiviral therapies and new diagnostic tests. In this article, taskforce members and other experts review what has been learned about ZIKV-induced disease in humans, its modes of transmission and the cause and nature of associated congenital manifestations. After describing the make-up of the taskforce, we summarize the emergence of ZIKV in the Americas, Africa and Asia, its spread by mosquitoes, and current control measures. We then review the spectrum of primary ZIKV-induced disease in adults and children, sites of persistent infection and sexual transmission, then examine what has been learned about maternal-fetal transmission and the congenital Zika syndrome, including knowledge obtained from studies in laboratory animals. Subsequent sections focus on vaccine development, antiviral therapeutics and new diagnostic tests. After reviewing current understanding of the mechanisms of emergence of Zika virus, we consider the likely future of the pandemic.

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Section: Emergence and Spread Of Zikv Infectionmentioning

confidence: 99%

Section: Mosquito Transmission and Control Measures (Nikos Vasilakis)mentioning

confidence: 99%

“…aegypti . So, taking into consideration its similar vector competence (Azar et al, 2017), Ae. albopictus is expected to play a secondary role in regions inhabited by similar populations.…”

Section: Mosquito Transmission and Control Measures (Nikos Vasilakis)mentioning

confidence: 99%

Section: Mosquito Transmission and Control Measures (Nikos Vasilakis)mentioning

confidence: 99%

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Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

et al. 2017

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“…19 In fact, Aedes spp. have been detected in these southern states [20][21][22] With this mosquito as their vector, will Dengue, Chikungunya, and Zika continue their rampant spread across the continent? Will yellow fever and Mayaro be the new plagues?…”

Section: Izurieta Et Almentioning

confidence: 99%

Mayaro virus: the jungle flu

Izurieta¹,

DeLacure²,

Izurieta³

et al. 2018

VAAT

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Abstract:Mayaro fever is an emerging acute viral disease endemic in Central and South America. Mayaro virus (MAYV) is classified in the Semliki Forest virus antigenic complex and shares similarities with the alphavirus Chikungunya virus and the flavivirus Dengue virus. MAYV is an arbovirus transmitted by Haemagogus janthinomys, with competence also demonstrated in Aedes aegypti, Aedes scapularis, and Anopheles quadrimaculatus. Outbreaks and small epidemics of Mayaro fever have occurred in several countries in northern South America and the Caribbean. In addition, travel-associated cases have been reported in European nationals returning from endemic areas. Clinical features of Mayaro fever include fever, chills, persistent arthralgia, retro-orbital pain, maculopapular rash, itching, dizziness, and, rarely, lymphadenopathy. Methods of control for MAYV are similar to those used for other sylvatic arboviruses. Although MAYV was discovered as long ago as the 1950s and continues to be prevalent in the tropical areas of the Americas, it remains neglected and under-studied. This paper provides a thorough and current review of the published MAYV literature ranging from its original description to modern outbreaks, and from the basic virus characteristics to the clinical and epidemiological aspects of this disease.

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Kinetics of Asian and African Zika virus lineages over single‐cycle and multi‐cycle growth in culture: Gene expression, cell killing, virus production, and mathematical modeling

Shi

Yin

2021

Biotech & Bioengineering

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Since 2014, an Asian lineage of Zika virus has caused outbreaks, and it has been associated with neurological disorders in adults and congenital defects in newborns.The resulting threat of the Zika virus to human health has prompted the development of new vaccines, which have yet to be approved for human use. Vaccines based on the attenuated or chemically inactivated virus will require large-scale production of the intact virus to meet potential global demands. Intact viruses are produced by infecting cultures of susceptible cells, a dynamic process that spans from hours to days and has yet to be optimized. Here, we infected Vero cells adhesively cultured in well-plates with two Zika virus strains: a recently isolated strain from the Asian lineage, and a cell-culture-adapted strain from the African lineage. At different time points post-infection, virus particles in the supernatant were quantified; further, microscopy images were used to quantify cell density and the proportion of cells expressing viral protein. These measurements were performed across multiple replicate samples of one-step infections every four hours over 60 h and for multi-step infections every four to 24 h over 144 h, generating a rich data set. For each set of data, mathematical models were developed to estimate parameters associated with cell infection and virus production. The African-lineage strain was found to produce a 14-fold higher yield than the Asian-lineage strain in one-step growth and a sevenfold higher titer in multi-step growth, suggesting a benefit of cell-culture adaptation for developing a vaccine strain. We found that image-based measurements were critical for discriminating among different models, and different parameters for the two strains could account for the experimentally observed differences. An exponential-distributed delay model performed best in accounting for multi-step infection of the Asian strain, and it highlighted the significant sensitivity of virus titer to the rate of viral degradation, with implications for optimization of vaccine production. More broadly, this study highlights how imagebased measurements can contribute to the discrimination of virus-culture models for the optimal production of inactivated and attenuated whole-virus vaccines.

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Differential Vector Competency of Aedes albopictus Populations from the Americas for Zika Virus

Cited by 82 publications

References 57 publications

Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

Mayaro virus: the jungle flu

Kinetics of Asian and African Zika virus lineages over single‐cycle and multi‐cycle growth in culture: Gene expression, cell killing, virus production, and mathematical modeling

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