Differential virulence of infectious hematopoietic necrosis virus (IHNV) isolated from salmonid fish in Gangwon Province, Korea

Kim, So‐Sun; Kim, Kwang Il; Yoo, Hae-Kyun; Han, Yu-Seon; Jegal, Myeong-Eun; Byun, Soon‐Gyu; Lim, Hyun-Jeong; Park, Jang-Su; Kim, Yung-Jin

doi:10.1016/j.fsi.2021.10.038

Cited by 6 publications

(2 citation statements)

References 42 publications

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“…Viruses demonstrate varying degrees of virulence based on genotype and host species ( Grund et al., 2018 ; Portugal et al., 2015 ; Kim et al., 2021 ; Emmenegger et al., 2013 ). Viral hemorrhagic septicemia virus (VHSV), to which the disease viral hemorrhagic septicemia (VHS) is attributed, has been reported to infect over 80 fish species in freshwater and marine environments ( Skall et al., 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Determination of the minimum infective dose of viral hemorrhagic septicemia virus (VHSV) in juvenile olive flounder, Paralichthys olivaceus using an immersion challenge model

Yoon,

Jang,

Kim

et al. 2024

Virus Research

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Section: Introductionmentioning

confidence: 99%

Determination of the minimum infective dose of viral hemorrhagic septicemia virus (VHSV) in juvenile olive flounder, Paralichthys olivaceus using an immersion challenge model

Yoon,

Jang,

Kim

et al. 2024

Virus Research

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“…Hence, there's a strong demand to develop antiviral measures to prevent infection by different strains of fish rhabdoviruses. Until now, researchers have focused more on its isolation, identification, molecular sequencing, phylogenetic analysis of different strains, susceptibility, and pathology to fish hosts [3][4][5][6]. In addition, other basic theoretical research on their pathogenic process, including the immunological and cellular modulation of different fish rhabdoviruses, was also investigated [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Antiviral Mechanism of Curcumin Analog EF-24 against Siniperca cachuatsi Rhabdovirus

Ju,

Ma,

et al. 2024

Fishes

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Siniperca chuatsi rhabdovirus (SCRV) is a major strain of viral fish virus resulting in multiple transmissions and devastating damage in aquaculture. Currently, there are no available approved therapeutics. In this study, we screened and identified a novel curcumin analog (EF-24) for evaluating its in vitro anti-SCRV properties and potential molecular mechanisms. Present results demonstrated that EF-24 could strongly delay the occurrence of cytopathic effects (CPEs) in epithelioma papulosum cyprinid cells (EPCs) and inhibit SCRV replication and viral nucleoprotein expression in the early stages of infection by the time-of-addition assay. Furthermore, flow cytometry analysis after Annexin V-FITC/PI double staining and immunofluorescence microscopy observation after JC-1 incubation showed that EF-24 downregulated cell mitochondrial apoptosis induced by SCRV. The enzymatic activities of caspase-3 and caspase-9 were also reduced after EF-24 treatment, indicating that EF-24 may protect cells from SCRV infection by decreasing mitochondrial intrinsic apoptosis in infected cells. Collectively, we demonstrated for the first time that the curcumin analog EF-24 possesses antiviral ability against SCRV, suggesting its potential for effective control of fish rhabdovirus spreading.

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Infectious hematopoietic necrosis virus (IHNV) nucleoprotein amino acid residues affect viral virulence and immunogenicity in rainbow trout (Oncorhynchus mykiss)

Xia

Zhang

et al. 2022

Fish & Shellfish Immunology

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Differential virulence of infectious hematopoietic necrosis virus (IHNV) isolated from salmonid fish in Gangwon Province, Korea

Cited by 6 publications

References 42 publications

Determination of the minimum infective dose of viral hemorrhagic septicemia virus (VHSV) in juvenile olive flounder, Paralichthys olivaceus using an immersion challenge model

Determination of the minimum infective dose of viral hemorrhagic septicemia virus (VHSV) in juvenile olive flounder, Paralichthys olivaceus using an immersion challenge model

Investigation of the Antiviral Mechanism of Curcumin Analog EF-24 against Siniperca cachuatsi Rhabdovirus

Infectious hematopoietic necrosis virus (IHNV) nucleoprotein amino acid residues affect viral virulence and immunogenicity in rainbow trout (Oncorhynchus mykiss)

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