Differentiated thyroid carcinoma: survival and prognostic factors

Marcos, Julia Sastre; Iglesias, Ofelia Llamazares; Delgado, Almudena Vicente; Martínez, Amparo Marco; Gaillemin, Bárbara Cánovas; Romero, Juan Luis Orradre; López, Miguel Ángel Morlan; López, José López

doi:10.1016/s2173-5093(11)70040-x

Cited by 2 publications

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“…In the fourth retrospective study reviewed on the issue of Differentiated thyroid carcinoma: the survival and prognostic factors of 308 patients with mean follow-up time of 8.9 +/-6.8yrs: it was found that the thyroid carcinoma related survival was 92.7%. Mortality rate of 4.9% and risk of death significantly increased with distant metastases, follicular histology, age at diagnosis older than 60 years and extrathyroid involvement [22].…”

Section: Literature Reviewmentioning

confidence: 98%

Results of Radioactive Iodine (131I) Therapy in Well Differentiated Thyroid Carcinoma: A Retrospective Study from the Tygerberg Hospital

Acullu

Fourie

Baatjes

et al. 2016

BJMMR

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Introduction:Well Differentiated thyroid carcinoma (WDTC) represents 80% of all thyroid malignant tumours, with good prognosis and a survival rate higher than 90% at 20 yrs. Total or subtotal thyroidectomy is the treatment of choice, with radioactive iodine (RAI) therapy reserved for adjuvant setting/ablation and/or as a curative treatment modality in patients with local recurrence and/or distant metastases. This retrospective study aimed to investigate the treatment outcome, Original Research Articlesurvival rate and prognostic factors in our institution over the past half-decade. Methods: A retrospective study was conducted of 33 patients with WDTC. Data were collected from 1 st January 2007 to 31 st December 2012 and included: Age at diagnosis, sex, histology, TNM stage, treatment received, indication for 131 I therapy, doses of 131 I, complication of treatment, follow-up diagnostic scan 123 I / Thyroglobulin, time of recurrence since surgery and cause of death. Prognostic factors were analysed using chi-square test and crude mortality rate was used. Results: Papillary subtype is the most common type of WDTC (63.6%); mean age at diagnosis is 50 years and female to male ratio is cosmopolitan at 3.1:1 with female preponderance. RAI therapy after thyroidectomy (total or subtotal) offers complete remission in 26/33 (78.8%) and the overall mortality rate was 3/33 (9.1%) p=0.023. Conclusion: RAI therapy is safe and effective in management of patients with WDTC. The initial surgical approach is the cornerstone in the subsequent outcome of RAI therapy with very poor outcome registered in unresectable thyroid tumour and in patients with multiple organ metastases.

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Section: Literature Reviewmentioning

confidence: 98%