Differentiating effects of somatomedin-C/insulin-like growth factor I and insulin on Leydig and Sertoli cell functions

Saez, J.M.; Chatelain, Pierre; Perrard-Sapori, Marie-Hélène; Jaillard, C.; Naville, Danielle

doi:10.1051/rnd:19880701

Cited by 32 publications

(29 citation statements)

References 58 publications

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“…In addition, we also observed a higher H (77%) and PIC (0.73%) when ILSTS002 was evaluated in our Braford population. Cows with the ILSTS002 allele (135 and 137 bp) showed lower viable embryos and higher calving intervals, indicating a disadvantage in reproductive performance in this species (SILVEIRA et al, 2013;WEIMER et al, 2007). In our study, we observed an increase in minor spermatozoa defects in bulls carrying a longer AFZ1 allele (121 and 127 bp) compared to animals carrying the short allele (113 and 119 bp).…”

Section: Discussionsupporting

confidence: 45%

“…Moreover, Silveira et al (2013) observed better reproductive performance in animals carrying the short IDVGA-51 allele (173-177 bp) than in animals carrying a longer allele (IDVGA-51*181), which had been classified as subfertile because they did not calve in the previous reproductive season and remained open after two breeding seasons. Cows carrying the IDVGA-51*181 allele showed a higher expression of LEP in the subcutaneous tissue, which is important in determining the nutritional effect on the animal's reproductive performance (ALMEIDA et al, 2000(ALMEIDA et al, , 2003.…”

Section: Discussionmentioning

confidence: 91%

“…The same authors suggest that the presence of IGF-I in semen and the ability of IGF-I to stimulate sperm motility play a possible regulatory role in spermatozoa prefertilization events in bovine species (HENRICKS et al, 1998). Indeed, studies have provided evidence that the presence of IGF-I in the male reproductive tract exerts a direct, as well as an indirect, influence on steroidogenesis (SAEZ et al, 1988) and cell proliferation and differentiation (OONK;GROOTEGOED, 1988).…”

Section: Discussionmentioning

confidence: 99%

“…The leptin (LEP) gene is directly related to the presence of alleles for IDVGA-51 located on the BTA4 that indicate an increasing calving interval in cows (ALMEIDA et al, 2000). The genetic diversity in crossbred beef cows demonstrates that ILSTS002 and BMS3004 are associated with the luteinizing hormone-β (LHβ) gene on BTA18 that is associated with reproductive performance (SILVEIRA et al, 2013). In addition, receptors for luteinizing hormone (LHR) and follicle stimulating hormone (FSHR) genes located at BTA11 are also involved in the regulation of several essential reproductive processes occurring at the gonadal level (CHENG, 1975;MA et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Candidate genes related to reproductive traits of Hereford and Braford bulls

Menegassi

Pereira

Aguiar

et al. 2018

SCA

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This study emphasized the importance of using candidate genes in predicting semen quality in bulls that can be used in cow-calf production. The aim of this study was to evaluate some candidate genes related to reproductive traits in Braford and Hereford bulls. All bulls (n=188) were submitted to breeding soundness evaluations at 24, 28, 32, and 36 months of age. The microsatellite markers ILSTS002 and BMS3004 associated with the luteinizing hormone-β (LHβ) gene, IDVGA-51 to leptin (LEP) gene, HEL5 and AFZ1 within the IGF-IR gene, and two SNP markers (LHR and FSHR) associated with the LHR and FSHR genes, respectively, were evaluated by the amplification of DNA products. The variation in the IDVGA-51 allele 177-185 showed polymorphic information content (PIC) associated with sperm motility and vigor traits in Hereford bulls. Hereford animals showed PIC of 0.36 to 0.75% along with expected heterozygosity (H) of 0.49 to 0.78%. Braford bulls that indicated the ILSTS002 allele 137-175 and AFZ1 allele 113-119 showed PIC associated with major and minor defects, respectively. The PIC ranged from 0.28 to 0.78%, with an expected H of 0.35 to 0.81%. AFZ1 allele 121-127 had the highest minor defects and ILSTS002 allele 125-135 showed the highest major defects from ejaculated semen in Braford bulls. In addition, IDVGA-51 allele 175 showed lower motility and vigor in Hereford bulls. The markers AFZ1 (IGF-IR) and ILSTS002 (LHβ) in Braford and IDVGA-51 (LEP) in Hereford bulls were effective in verifying the reproductive traits of the bulls. Key words: Molecular markers. Single nucleotide polymorphisms. Microsatellites. Genetic variability. Braford and Hereford breeds. ResumoEste estudo enfatizou a importância do uso de genes candidatos na predição da qualidade do sêmen em touros que podem ser utilizados na produção de bezerros. O objetivo deste estudo foi avaliar alguns

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Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Candidate genes related to reproductive traits of Hereford and Braford bulls

Menegassi

Pereira

Aguiar

et al. 2018

SCA

View full text Add to dashboard Cite

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“…1). Although we are not aware of direct evidence that insulin promotes the proliferation of male germ cells and Sertoli cells in mice, this has been shown in the chicken (67), swine (68), and newt (69). Insulins have also been shown to have other roles in the reproductive tract.…”

Section: Discussionmentioning

confidence: 93%

The RHOX Homeodomain Proteins Regulate the Expression of Insulin and Other Metabolic Regulators in the Testis

MacLean

Welborn

et al. 2013

Journal of Biological Chemistry

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Background: RHOX5 is a transcription factor important for spermatogenesis. Results: Using Rhox5-null mice, we demonstrate that RHOX5 regulates key metabolism genes, including insulin (Ins), resistin (Retn), and adiponectin (Adipoq) in specific cell types and developmental stages in the testis. Conclusion: RHOX5 is a crucial regulator of metabolism genes in the testis. Significance: This work provides a framework for understanding why metabolism defects cause male infertility.

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Morphological effects of diabetes on the granular ducts and acini of the rat submandibular gland

Anderson

Suleiman

Garrett

1994

Microscopy Res & Technique

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Effects of experimental diabetes on rat submandibular glands have been documented, but earlier reports suggested that diabetes caused an extensive cellular degeneration and a replacement of the parenchymal cells by fibrous connective tissue. Such observations, however, are difficult to reconcile with the relatively normal physiological responsiveness of the gland (Anderson and Suleiman, 1989). This study, therefore, reexamined the histological, histochemical and ultrastructural effects of streptozotocin-induced diabetes on rat submandibular glands. The tissues were examined at 3 weeks, and 3 and 6 months after the induction of diabetes, and compared with glands from age-matched controls by both light and electron microscopy. Light microscopically, the proportional volumes of the acini and granular ducts remained constant in control rats at about 48% and 38% respectively. In diabetic animals the volume density of the acini increased progressively to 62%, whereas that of the granular ducts decreased to 20%. The diameter and number of granular ducts were reduced in diabetic animals, but acinar cell profile area was only affected 6 months after the induction of diabetes. Ultrastructurally, there was an accumulation of lipid in the acinar cells and, with increasing duration of diabetes, the number of autophagic structures in both the acini and the granular ducts increased. Although there was evidence of some cellular degeneration it was never excessive. Morphometry showed that the volume density of secretory granules within the acinar cells was unaffected, but there was a significant reduction in the volume density of secretory granules within the granular ducts. Thus, in the rat submandibular gland the greatest effect of streptozotocin-induced diabetes was to cause hypotrophic changes in the cells of the granular ducts. The relative contributions of a direct effect of insulin insufficiency and the hypogonadal effects of diabetes, however, are not known.

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Differentiating effects of somatomedin-C/insulin-like growth factor I and insulin on Leydig and Sertoli cell functions

Cited by 32 publications

References 58 publications

Candidate genes related to reproductive traits of Hereford and Braford bulls

Candidate genes related to reproductive traits of Hereford and Braford bulls

The RHOX Homeodomain Proteins Regulate the Expression of Insulin and Other Metabolic Regulators in the Testis

Morphological effects of diabetes on the granular ducts and acini of the rat submandibular gland

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