Differentiating scrub typhus meningoencephalitis, from tuberculous meningitis: Two case reports and a review

Silva, C. M. De; Fonseka, C. L.; Nanayakkara, S.D.; Singhapura, S. D. A. L.; Palangasinghe, D R; Hewawithana, J. S.; Pathirana, K.D.; Bodinayake, Champica K

doi:10.4038/gmj.v23i1.7989

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“…Literature mentions that CSF in typhus meningoencephalitis can show a spectrum of changes. It may show leukocytosis, elevated protein, and slightly reduced glucose resembling viral meningoencephalitis, leptospirosis, and in certain instances tuberculous meningitis 3 .…”

Section: Discussionmentioning

confidence: 99%

Scrub typhus Meningoencephalitis : Diagnostic dilemma

Narkhede,

Weling,

Prajapati

2023

Nep J Neurosci

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Background: Neurological involvement in the form of meningitis or meningoencephalitis, although well documented in scrub typhus, has not been extensively studied in the pediatric population. It is seldom considered in the differential diagnosis of meningitis in the Indian subcontinent. Case Presentation: We report a case of Scrub typhus meningitis in 13year old male child. The Cerebrospinal Fluid (CSF) revealed lymphocytic pleocytosis, raised proteins and a normal glucose level. Conclusion : Early diagnosis and prompt institution of doxycycline therapy may lead to early cure of scrub typhus even when features of meningitis supervene. However, Ceftriaxone which is commonly used to treat bacterial meningitis is suboptimal in the treatment of scrub typhus. Key words : Scrub typhus, Meningoencephalitis, CSF

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Section: Discussionmentioning

confidence: 99%