Differentiation and vascularization of the metanephric kidney grafted on the chorioallantoic membrane

Sariola, Hannu; Ekblom, Peter; Lehtonen, Eero; Saxén, Lauri

doi:10.1016/0012-1606(83)90180-x

Cited by 218 publications

(110 citation statements)

References 21 publications

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“…Interspecies cross transplantation experiments of prevascular embryonic kidneys were originally performed into quail chorioallantoic membrane because of the presence of a characteristic quail nuclear marker that could easily track the contribution of the host tissue. 25,35 Those experiments show the presence of hostderived ECs and mesangial cells within the embryonic kidney and suggest an extrarenal source for ECs and mesangial cells. The development of genetically-labeled mice with traceable reporters allowed further experiments in mice.…”

Section: Progenitors Of Mural Cells Pericytes and Interstitial Cellsmentioning

confidence: 95%

Development of the Renal Arterioles

López

Gómez

2011

Journal of the American Society of Nephrology

128

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Section: Progenitors Of Mural Cells Pericytes and Interstitial Cellsmentioning

confidence: 95%

Development of the Renal Arterioles

López

Gómez

2011

Journal of the American Society of Nephrology

128

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“…However, this does not predict whether the recombined tissue will be able to successfully integrate into a host animal. Previous studies have demonstrated that early avascular embryonic kidneys can be implanted into a host animal to recruit a vasculature with functional glomeruli (3)(4)(5)(6)(7)(8). Therefore, we implanted the recombined kidney-like tissue (from a recombination of branched T-shaped UB and MM) under the renal capsule of a host rat.…”

Section: Implantation and Apparent Vascularization Of The Recombinedmentioning

confidence: 99%

“…For example, the extracorporeal renal tubule assist device utilizes a synthetic hemofilter connected in series with a bioreactor cartridge containing human proximal tubule cells (2). In addition, renal primordia obtained at a sufficiently early developmental stage have been demonstrated to undergo differentiation and grow when transplanted into animal hosts (3)(4)(5)(6)(7)(8). In vitro propagation of the branching ureteric bud or subdivided progenitor tissue has been proposed as a method for generating a number of kidneys from a single progenitor tissue (9).…”

mentioning

confidence: 99%

Staged in vitro reconstitution and implantation of engineered rat kidney tissue

Rosines

Sampogna²,

Johkura³

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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A major hurdle for current xenogenic-based and other approaches aimed at engineering kidney tissues is reproducing the complex three-dimensional structure of the kidney. Here, a stepwise, in vitro method of engineering rat kidney-like tissue capable of being implanted is described. Based on the fact that the stages of kidney development are separable into in vitro modules, an approach was devised that sequentially induces an epithelial tubule (the Wolffian duct) to undergo in vitro budding, followed by branching of a single isolated bud and its recombination with metanephric mesenchyme. Implantation of the recombined tissue results in apparent early vascularization. Thus, in principle, an unbranched epithelial tubular structure (potentially constructed from cultured cells) can be induced to form kidney tissue such that this in vitro engineered tissue is capable of being implanted in host rats and developing glomeruli with evidence of early vascularization. Optimization studies (of growth factor and matrix) indicate multiple suitable combinations and suggest both a most robust and a minimal system. A whole-genome microarray analysis suggested that recombined tissue recapitulated gene expression changes that occur in vivo during later stages of kidney development, and a functional assay demonstrated that the recombined tissue was capable of transport characteristic of the differentiating nephron. The approach includes several points where tissue can be propagated. The data also show how functional, 3D kidney tissue can assemble by means of interactions of independent modules separable in vitro, potentially facilitating systems-level analyses of kidney development. kidney development ͉ systems biology ͉ tissue engineering

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“…Vasculogenesis is 0 1995 WILEY-LISS, INC. known to occur within both the embryonic and extraembryonic mesoderm (Wagner, 1980) and is characterized by the differentiation of angioblasts from the mesoderm and either their immediate aggregation to give rise to endothelium or their directed migration through the embryo and eventual segregation into vascular cords (Pardanaud et al, 1987(Pardanaud et al, , 1989Poole, 1988, 1991;Noden, 1989;Wagner, 1980). The formation of the larger vascular network which includes the dorsal aorta, blood islands, the endocardium of the heart, and the cardinal and vitelline vessels, is accomplished by vasculogenesis (Kadokawa et al, 1990;Noden, 19891, whereas the vascularization of many organs and structures such as intersomatic vessels, the brain and kidney, are accomplished by a n active angiogenic process (Kadokawa et al, 1990;Sariola et al, 1983;Noden, 1989). The factors controlling both vasculogenesis and angiogenesis remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development

Dumont

Fong

Puri

et al. 1995

Developmental Dynamics

515

276

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We report the detailed developmental expression profiles of three endothelial specific receptor tyrosine kinases (RTKs) flk-1, tek, tie, as well as vascular endothelial growth factor (VEGF), the flk-1 ligand. We also examined the expression of the other VEGF receptor, flt-1, during placental development. flk-1, tek, and tie transcripts were detected sequentially at one-half day intervals starting at E7.0, suggesting that each of these RTKs play a unique role during vascularization of the mouse embryo. All three RTKs were expressed in the extraembryonic and embryonic mesoderm in regions that eventually give rise to the vasculature. Except for the expression of tek and flk-1 in the mesoderm of the amnion, the expression of these RTKs from E8.5 onwards was virtually indistinguishable. An abundant amount of flt-1 transcripts was found in the spongiotrophoblast cells of the developing placenta from E8.0 onwards. This cellular compartment is located between the maternal and labyrinthine layers of the placenta, which both express VEGF. VEGF transcripts were detected as early as E7.0 in the endoderm juxtaposed to the flk-1 positive mesoderm, and later in development VEGF expression displayed an expression profile both contiguous with that of flk-1, and also in tissues found some distance from the flk-1-expressing endothelium. These results suggest a possible dual role for VEGF which includes a chemotactic and/or a cellular maintenance role for VEGF during vascularization of the mouse embryo. o 1995 Wiley-Liss, Inc.

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Differentiation and vascularization of the metanephric kidney grafted on the chorioallantoic membrane

Cited by 218 publications

References 21 publications

Development of the Renal Arterioles

Development of the Renal Arterioles

Staged in vitro reconstitution and implantation of engineered rat kidney tissue

Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development

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