Differentiation between benign and malignant disease of the breast using digital subtraction angiography of the breast

Watt, A C; Ackerman, L V; Shetty, P.C.; Burke, Matthew; Flynn, Michael J.; Grodsinsky, Carlos M.; Fine, Gerald; Wilderman, S.J.

doi:10.1002/1097-0142(19850915)56:6<1287::aid-cncr2820560611>3.0.co;2-l

Cited by 33 publications

(16 citation statements)

References 6 publications

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“…Early work involving angiography of breast carcinomas demonstrated chaotic vascular patterns including abnormal feeding vessels [11,12]. In a separate study of endothelial cell proliferation (an essential precursor to angiogenesis) in breast lesions, Fox et al showed a predominant presence at the periphery for tumors [13].…”

Section: Resultsmentioning

confidence: 99%

Three-dimensional (3D) parametric maps for visualization of breast lesion vasculature using subharmonic imaging

Sridharan

Eisenbrey

Machado

et al. 2014

2014 IEEE International Ultrasonics Symposium

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Ability to visualize breast lesion vascularity and quantify the vascular heterogeneity using contrast-enhanced threedimensional (3D) harmonic (HI) and subharmonic (SHI) ultrasound imaging was investigated in a clinical population. Patients (n = 134) identified with breast lesions on mammography were scanned using power Doppler imaging (PDI), contrastenhanced 3D HI and 3D SHI on a modified Logiq 9 scanner (GE Healthcare). Ultrasound contrast agent (UCA) flow was identified in 4D View TM (GE Medical Systems) and used to generate a map of time-intensity curves for each lesion volume. Time-points corresponding to baseline, peak intensity and washout of UCA were identified to develop vascular heterogeneity plots. Vascularity was observed with PDI in 82 lesions (61 benign and 21 malignant). 3D HI showed flow in 8 lesions (5 benign and 3 malignant), while 3D SHI visualized flow in 68 (49 benign and 19 malignant). Analysis of vascular heterogeneity in the 3D SHI volumes found benign lesions having a significant difference in vascularity betweencentral and peripheral sections (1.71 ± 0.96 vs. 1.13 ± 0.79 dB, p < 0.001, respectively) whereas malignant lesions showed no difference (1.66 ± 1.39 vs. 1.24 ± 1.14 dB, p = 0.24), indicative of more vascular coverage. These preliminary results suggest quantitative evaluation of vascular heterogeneity in breast lesions using contrast-enhanced 3D SHI is feasible and able to detect variations in vascularity between central and peripheral sections for benign and malignant lesions. Finally, 3D parametric volumes were produced for perfusion (PER) and area under the curve (AUC).

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Section: Resultsmentioning

confidence: 99%

Three-dimensional (3D) parametric maps for visualization of breast lesion vasculature using subharmonic imaging

Sridharan

Eisenbrey

Machado

et al. 2014

2014 IEEE International Ultrasonics Symposium

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“…Watt et al (16,17) and Ackerman et al (18) performed digital subtraction angiography of the breast, using an x-ray image intensifier in a conventional angiography system. They were able to demonstrate that benign and malignant lesions could be differentiated according to the strength of enhancement (referred to as "blush").…”

Section: Temporal Subtraction Angiographymentioning

confidence: 99%

“…Watt et al (16,17) and Ackerman et al (18) used temporal subtraction to depict the contrast enhancement. This technique, illustrated in Figure 1a, is analogous to the vast majority of digital subtraction angiography performed today.…”

Section: Temporal Subtraction Angiographymentioning

confidence: 99%

X-Ray Polarization Imaging

Maidment¹

2006

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. (From -To) REPORT DATE (DD-MM-YYYY) 01-06-2006 REPORT TYPE Final DATES COVERED PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERUniversity of Pennsylvania Philadelphia, PA 19175 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES-original document contains color ABSTRACTConventional mammography evaluates the spatial arrangement of tissue in the breast; the recorded signal is determined by the x-ray attenuation of the materials in each projection. Due to the low x-ray energy, every x-ray attenuated by the breast is absorbed by the breast (i.e., all of the x-ray energy is deposited in the breast). We have investigated whether it is possible to produce breast images based on x-ray polarization. Polarization radiography appeared to have the potential to supplement mammographic images by imaging the ability of breast tissue to rotate the x-ray polarization vector. We had hoped that new information about the breast could be gleaned at a low dose to the breast; preference being given to x-rays which would pass through the breast and have altered polarization, rather than being absorbed by the breast). We performed fundamental experiments regarding x-ray polarization to determine whether the polarization effect was sufficiently large to allow it to be used to produce images. Two different x-ray polarimeters were developed and tested. We were able to demonstrate polarization of the incident x-ray beam. However, neither polarimeter allowed successful measurement of polarization alterations of any material. We did, however, develop an excellent model of x-ray spectra, which has already seen wide usage. SUBJECT TERMS Conclusions……………………………………………………………………………………………………………29 References………………………………………………………………………………………………………………30 Appendices………………………………………………………………………………………………………………32Page 4 IntroductionAt optical energies, the pol...

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“…These neo-angiogenic vessels tend to be leaky, allowing contrast agent to pool in the extravascular space of tumours. Early studies by Chang, Watt and Ackerman in the 1980's each demonstrated that malignant lesions enhance more strongly than benign lesions following injection of an iodinated contrast medium [7,8,9]. More recently, similar lesion signal enhancement has been achieved by the use of Gd-based contrast agents in dynamic contrast-enhanced MRI (DCE MRI) [10,11].…”

Section: Introductionmentioning

confidence: 99%

Quantitative flow phantom for contrast-enhanced breast tomosynthesis

et al. 2007

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The use of contrast agents can help to overcome a lack of intrinsic radiographic contrast between malignant and benign breast tissue by taking advantage of the properties of tumour angiogenesis. Studies of contrast-enhanced mammography have demonstrated increased lesion conspicuity and have shown that this technique provides information on contrast uptake kinetics. It has been suggested that malignant and benign lesions can be differentiated in part by their uptake kinetics, so this additional data may lead to more accurate diagnoses. Tomosynthesis is a 3D x-ray imaging technique that permits lesion depth localization and increased conspicuity in comparison with 2D x-ray projection techniques. This modality, used in combination with contrast agents, promises to be a sensitive method of breast cancer detection. To develop the technique of contrast-enhanced breast tomosynthesis, a dynamic flow phantom has been constructed to provide the same types of imaging challenges anticipated in the clinical setting. These challenges include a low-contrast tumour space, relevant temporal contrast agent uptake and washout profiles, and a need for quantitative analysis of enhancement levels. The design of a flow phantom will be presented that includes a dynamic tumour space, a background that masks the tumour space in images without contrast enhancement, and flow characteristics that simulate tumour contrast agent uptake and washout kinetics. The system is calibrated to relate signal to concentration of the contrast agent using a well plate filled with iodinated water. Iodine detectability in the flow phantom is evaluated in terms of the signal-difference-to-noise ratio for various tomosynthesis image acquisition parameters including number of acquired angular views, angular extent, and reconstruction voxel size.

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Differentiation between benign and malignant disease of the breast using digital subtraction angiography of the breast

Cited by 33 publications

References 6 publications

Three-dimensional (3D) parametric maps for visualization of breast lesion vasculature using subharmonic imaging

Three-dimensional (3D) parametric maps for visualization of breast lesion vasculature using subharmonic imaging

X-Ray Polarization Imaging

Quantitative flow phantom for contrast-enhanced breast tomosynthesis

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