Differentiation between bipolar disorder and schizophrenia revealed by neural oscillation to speech sounds: an MEG study

Oribe, Naoya; Onitsuka, Toshiaki; Hirano, Shogo; Hirano, Yoji; Maekawa, Toshihiko; Obayashi, Choji; Ueno, Takefumi; Kasai, Kiyoto; Kanba, Shigenobu

doi:10.1111/j.1399-5618.2010.00876.x

Cited by 50 publications

(20 citation statements)

References 33 publications

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“…Significant differences in gamma-band power in schizophrenia have been observed in a number of paradigms, but reports of decreases in gamma-band power in SP are more common than increases (for a review, see Sun et al, 2011). It is important to note that some of these studies limited their analysis to specific regions of interest (e.g., Teale et al, 2008; Oribe et al, 2010), thereby limiting the scope of the study to the region analyzed. Our analysis limited the frequency range to the low gamma-band, yet performed comparisons across the full sensor array providing a broader view of changes in gamma-band power.…”

Section: Discussionmentioning

confidence: 99%

Multisensory stimuli elicit altered oscillatory brain responses at gamma frequencies in patients with schizophrenia

Stone

Coffman

Bustillo

et al. 2014

Front. Hum. Neurosci.

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Deficits in auditory and visual unisensory responses are well documented in patients with schizophrenia; however, potential abnormalities elicited from multisensory audio-visual stimuli are less understood. Further, schizophrenia patients have shown abnormal patterns in task-related and task-independent oscillatory brain activity, particularly in the gamma frequency band. We examined oscillatory responses to basic unisensory and multisensory stimuli in schizophrenia patients (N = 46) and healthy controls (N = 57) using magnetoencephalography (MEG). Time-frequency decomposition was performed to determine regions of significant changes in gamma band power by group in response to unisensory and multisensory stimuli relative to baseline levels. Results showed significant behavioral differences between groups in response to unisensory and multisensory stimuli. In addition, time-frequency analysis revealed significant decreases and increases in gamma-band power in schizophrenia patients relative to healthy controls, which emerged both early and late over both sensory and frontal regions in response to unisensory and multisensory stimuli. Unisensory gamma-band power predicted multisensory gamma-band power differently by group. Furthermore, gamma-band power in these regions predicted performance in select measures of the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) test battery differently by group. These results reveal a unique pattern of task-related gamma-band power in schizophrenia patients relative to controls that may indicate reduced inhibition in combination with impaired oscillatory mechanisms in patients with schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Multisensory stimuli elicit altered oscillatory brain responses at gamma frequencies in patients with schizophrenia

Stone

Coffman

Bustillo

et al. 2014

Front. Hum. Neurosci.

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“…On the other hand, two meta-analyses of volumetric studies of superior temporal cortices did not report any significant differences between patients with bipolar disorder and healthy participants (Arnone et al, 2009; Kempton et al, 2008). However, primary and secondary auditory cortices are located in the region and functional studies consistently reported auditory processing disturbances in both schizophrenia (Dierks et al, 1999; Domjan et al, 2012; Umbricht and Krljes, 2005) and bipolar disorder (Hall et al, 2009; Oribe et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

“…Since glutamate is the major excitatory neurotransmitter and since the EEG signal consists of excitatory end synaptic potentials, auditory processing deficits detected in both schizophrenia (Oribe et al, 2010; Umbricht and Krljes, 2005) and bipolar disorder (Atagun et al, 2014; Ethridge et al, 2012; Hall et al, 2009) could potentially be due to glutamatergic dysfunction in the auditory cortices (Javitt, 2009). Glutamate-modulating agents have been found to be efficacious in the treatment of mood disorders both in pre-clinical (Skolnick et al, 2009) and clinical studies (Machado-Vieira et al, 2012; Sanacora et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Investigation of Heschl's gyrus and planum temporale in patients with schizophrenia and bipolar disorder: A proton magnetic resonance spectroscopy study

Atagün

Sikoglu

Can

et al. 2015

Schizophrenia Research

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Background Superior temporal cortices include brain regions dedicated to auditory processing and several lines of evidence suggest structural and functional abnormalities in both schizophrenia and bipolar disorder within this brain region. However, possible glutamatergic dysfunction within this region has not been investigated in adult patients. Methods Thirty patients with schizophrenia (38.67 ± 12.46 years of age), 28 euthymic patients with bipolar I disorder (35.32 ± 9.12 years of age), and 30 age-, gender- and education- matched healthy controls were enrolled. Proton Magnetic Resonance Spectroscopy data were acquired using a 3.0T Siemens MAGNETOM TIM Trio MR system and single voxel Point REsolved Spectroscopy Sequence (PRESS) in order to quantify brain metabolites within the left and right Heschl's Gyrus and Planum Temporale of superior temporal cortices. Results There were significant abnormalities in Glutamate (Glu) (F(2,78)=8.52, p<0.0001), n-Acetyl Aspartate (tNAA) (F(2,81)=5.73, p=0.005), Creatine (tCr) (F(2,83)=5.91, p=0.004) and Inositol (Ins) (F(2,82)=8.49, p<0.0001) concentrations in the left superior temporal cortex. In general, metabolite levels were lower for bipolar disorder patients when compared to healthy participants. Moreover, patients with bipolar disorder exhibited significantly lower tCr and Ins concentrations when compared to schizophrenia patients. In addition, we have found significant correlations between the superior temporal cortex metabolites and clinical measures. Conclusion As the left auditory cortices are associated with language and speech, left hemisphere specific abnormalities may have clinical significance. Our findings are suggestive of shared glutamatergic abnormalities in schizophrenia and bipolar disorder.

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“…Numerous studies have reported that while neurophysiological responses to vowel sounds are lateralized, those to nonspeech sounds are not [9,10,11,12]. Clinically, it has been reported that these lateralized early neural responses to vowel sounds are disturbed in psychotic patients [13,14,15]. Moreover, abnormalities of the perceptual process in the audiovisual integration stimuli have been reported in schizophrenia [16].…”

Section: Introductionmentioning

confidence: 99%

Early Integration Processing between Faces and Vowel Sounds in Human Brain: An MEG Investigation

et al. 2015

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Objective: Unconscious fast integration of face and voice information is a crucial brain function necessary for communicating effectively with others. Here, we investigated for evidence of rapid face-voice integration in the auditory cortex. Methods: Magnetic fields (P50m and N100m) evoked by visual stimuli (V), auditory stimuli (A) and audiovisual stimuli (VA), i.e. by face, vowel and simultaneous vowel-face stimuli, were recorded in 22 healthy subjects. Magnetoencephalographic data from 28 channels around bilateral auditory cortices were analyzed. Results: In both hemispheres, AV - V showed significantly larger P50m amplitudes than A. Additionally, compared with A, the N100m amplitudes and dipole moments of AV - V were significantly smaller in the left hemisphere, but not in the right hemisphere. Conclusions: Differential changes in P50m (bilateral) and N100m (left hemisphere) that occur when V (faces) are associated with A (vowel sounds) indicate that AV (face-voice) integration occurs in early processing, likely enabling us to communicate effectively in our lives.

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Differentiation between bipolar disorder and schizophrenia revealed by neural oscillation to speech sounds: an MEG study

Abstract: The present study showed that different patterns in eNO to speech sounds are present in BP, SZ, and NC subjects. The eNO to speech sounds in the left hemisphere is a potential index to distinguish BP and SZ.

Cited by 50 publications

References 33 publications

Multisensory stimuli elicit altered oscillatory brain responses at gamma frequencies in patients with schizophrenia

Multisensory stimuli elicit altered oscillatory brain responses at gamma frequencies in patients with schizophrenia

Investigation of Heschl's gyrus and planum temporale in patients with schizophrenia and bipolar disorder: A proton magnetic resonance spectroscopy study

Early Integration Processing between Faces and Vowel Sounds in Human Brain: An MEG Investigation

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