Differentiation between diamagnetic and paramagnetic cerebral lesions based on magnetic susceptibility mapping

Schweser, Ferdinand; Deistung, Andreas; Lehr, Berengar Wendel; Reichenbach, Jürgen R.

doi:10.1118/1.3481505

Cited by 228 publications

(218 citation statements)

References 51 publications

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“…These advanced MR technologies include susceptibility weighted imaging (SWI) for hemorrhage detection, 13 MR spectroscopy (MRS) for metabolite measurement, 14 diffusion weighted and diffusion tensor imaging (DWI/DTI) for edema quantification 15 and axonal injury detection, 16 perfusion weighted imaging (PWI) and arterial spin labeling (ASL) to measure blood flow to brain tissue, 17 and functional MRI (fMRI), which measures changes in blood oxygen level locally in response to neuronal activity. 18 Having a number of imaging biomarkers, all of which are obtained in a single scanning session (or multiple for longitudinal study) and are sensitive to different consequence of traumatic injury affords great advantages: 1) enhanced sensitivity; 2) ability to study interrelationships among these biomarkers and between the biomarkers and clinical/ neurocognitive deficits; 3) improved clinical management resulting from more precise characterization of injuries; and 4) enhanced power of clinical interventional studies (see above).…”

Section: Discussionmentioning

confidence: 99%

“…However, the use of phase information itself has stimulated great interest both as a source of contrast (4-6) and a source for producing susceptibility maps (SM) (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). The impetus for solving the inverse problem from magnetic field perturbation came from the work described by Deville et al (25).…”

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confidence: 99%

“…Unfortunately, this inverse process is ill-posed and requires a regularization procedure to estimate the SM. There are a variety of approaches to tackle this problem (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). One unique method uses a multiple orientation data acquisition to remove the singularities (17).…”

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Development of Magnetic Resonance Imaging Biomarkers for Traumatic Brain Injury

Haacke¹

2012

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY)2. REPORT TYPE 3. DATES COVERED (From -To) 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER E-Mail:5f. WORK UNIT NUMBER The purpose of this research program is to develop an imaging-based protocol to improve diagnosis and outcome prediction of mild traumatic brain injury (mTBI). It includes the development of a modern technology for processing susceptibility maps to evaluate the presence of bleeding and deoxyhemoglobin and the study of sensitivity of new MR imaging technology in detecting mild TBI. Our major findings relate directly to our specific aims. First, we have demonstrated that these new advanced MRI methods nicely complement conventional imaging methods in their ability to detect mTBI in the acute setting. Second, susceptibility weighted imaging and mapping (SWIM) are able to delineate venous structures and microbleeds making it possible to quantify and monitor evolution of pathological changes. Third, we have developed the process by which to evaluate DTI data throughout the entire brain to look for local variations in ADC and FA values to assess tissue damage. And fourth, we have begun to collect imaging and neuropsychological data for both volunteers and mTBI patients during the last quarter of this year. The significance of this work to date is that we are now able to find evidence of damage in mTBI where that has heretofore been difficult with cMRI. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTMild traumatic brain injury, susceptibility weighted imaging and mapping, INTRODUCTIONBackground:!Traumatic brain injury (TBI) has been labeled as a "signature wound" in the anti-terrorism wars in Iraq and Afghanistan. 15% -25% of surveyed returning service members have been reported to have possible long-term mild tra...

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Section: Discussionmentioning

confidence: 99%

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Development of Magnetic Resonance Imaging Biomarkers for Traumatic Brain Injury

Haacke¹

2012

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“…Postprocessing is technically demanding and may require a significant amount of time to calculate the images. 44,58 An online reconstruction technique has shown promise in addressing this practical limitation, reducing the image construction time to less than 30 seconds on standard computers.…”

Section: Disadvantages Of Susceptibility-based Imaging Techniquesmentioning

confidence: 99%

Magnetic resonance imaging of the subthalamic nucleus for deep brain stimulation

Chandran¹,

Bynevelt

Lind

2016

JNS

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F uture progress to refine targets for deep brain stimulation (DBS) is critically dependent on precise placement and verification of electrodes in the brain. No stereotactic target is of more clinical importance or more nuanced regarding its imaging than the subthalamic nucleus (STN). The STN is difficult to image because of its biconvex shape, small size, oblique spatial orientation in 3 planes, and its close proximity to the substantia nigra (SN).3 A high level of accuracy is required as the motor region of the STN is posterolateral, and unwanted stimulation side effects may occur as a result of direct stimulation or spread to the anteromedial nonmotor area and the adjacent corticospinal tract. 9,18,31,56 Current imaging of STN borders is difficult.Targeting of the STN has historically been performed indirectly; the neurosurgeon predicts the location of the STN based on coordinates derived from atlases. These coordinates have often been related to the midcommissural point, which was derived from x-ray ventriculography but also from CT and MRI. Retaining this indirect, coordinate-based approach has been attractive to neurosurgeons. Experience in using this approach has been handed down from the past and can be used even with modern noninvasive imaging, and targeting preferences can be easily communicated between surgeons. The problem with indirect targeting is that different patients have different STN sizes, shapes, and positions.38 Direct targeting is an attempt to locate the STN in each individual patient.Poor image quality on traditional 1.5 tesla (T) scanners and primitive pulse sequences that do not provide adequate contrast at the level of the STN have limited the progression of direct targeting in some centers. Also hindering the development of stereotactic MRI are concerns about image distortion with higher field strength; traditional stereotactic head frames and localizers are too bulky to permit the use of high-quality, multichannel MRI head coils.Despite these challenges, higher field strength scanners and new pulse sequences have improved image quality to a point that some groups have adopted direct targeting of the STN, based on MRI.3,9,37 Difficulty delineating the STN and spatial inaccuracy has resulted in reluctance from others to abandon adjuncts such as CT/MRI merge and intraoperative electrophysiology.Traditionally, T2-weighted imaging (T2WI) has been used to plan for direct targeting of the STN using a variety of imaging parameters (Fig. 1).9 Although T2WI is useful, it is difficult to clearly delineate the STN from the SN and, to a lesser extent, the zona incerta (ZI). 22,32,37 abbreviatioNs CNR = contrast-to-noise ratio; DBS = deep brain stimulation; DTI = diffusion tensor imaging; FA = fractional anisotropy; FGATIR = fast gray matter acquisition T1 IR; FLAIR = fluid attenuated IR; FLASH = fast low-angle shot; FSE = fast spin echo; GRE = gradient echo; IR = inversion recovery; NSA = number of signal averages; PSIR = phase-sensitive IR; QSM = quantitative susceptibility mapping; SE = spin ...

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“…Phase images could be available in measuring iron content and other substances that change the local field. The development of SWI has opened the door to upgraded contrast and upgraded the determination of hemorrhage in tumors [24,25]. DTI: diffusion tensor imaging…”

Section: Susceptibility-weighted Imagingmentioning

confidence: 99%

How Can New Imaging Modalities Help in the Practice of Radiology?

et al. 2017

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The purpose of this article was to provide an up-to-date review on the spectrum of new imaging applications in the practice of radiology. New imaging techniques have been developed with the objective of obtaining structural and functional analyses of different body systems. Recently, new imaging modalities have aroused the interest of many researchers who are studying the applicability of these modalities in the evaluation of different organs and diseases. In this review article, we present the efficiency and utilization of current imaging modalities in daily radiological practice.

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Differentiation between diamagnetic and paramagnetic cerebral lesions based on magnetic susceptibility mapping

Cited by 228 publications

References 51 publications

Development of Magnetic Resonance Imaging Biomarkers for Traumatic Brain Injury

Development of Magnetic Resonance Imaging Biomarkers for Traumatic Brain Injury

Magnetic resonance imaging of the subthalamic nucleus for deep brain stimulation

How Can New Imaging Modalities Help in the Practice of Radiology?

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