Differentiation between major depressive disorder and bipolar disorder by auditory steady-state responses

Isomura, Shuichi; Onitsuka, Toshiaki; Tsuchimoto, Rikako; Nakamura, Itta; Hirano, Shogo; Oda, Yuko; Oribe, Naoya; Hirano, Yoji; Ueno, Takefumi; Kanba, Shigenobu

doi:10.1016/j.jad.2015.11.034

Cited by 87 publications

(49 citation statements)

References 39 publications

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“…The 40‐Hz stimulus produces the strongest steady state response, but the exact mechanism is not fully understood . It has been used as an index of the ability for gamma band frequency generation in local cortical networks in mental disorders, including schizophrenia, bipolar disorder, and autism spectrum disorder (ASD) …”

Section: Studies Of Auditory Steady‐state Responsementioning

confidence: 99%

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Auditory steady‐state response at 20 Hz and 40 Hz in young typically developing children and children with autism spectrum disorder

Kudoh

Ikeda

Takahashi

et al. 2020

Psychiatry Clin Neurosci

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Aim The early detection of autistic tendencies in children is essential for providing proper care and education. The auditory steady‐state response (ASSR) provides a passive, non‐invasive technique for assessing neural synchrony at specific response frequencies in many mental disorders, including autism spectrum disorder (ASD), but few studies have investigated its use in young children. This study investigated the ASSR at 20 Hz and 40 Hz in typically developing (TD) children and children with ASD aged 5–7 years. Methods The participants were 23 children with ASD and 32 TD children aged 5–7 years. Using a custom‐made magnetoencephalography device, we measured ASSR at 20 Hz and 40 Hz, compared the results between groups, and evaluated the association with intellectual function as measured by Kaufmann Assessment Battery for Children. Results Responses to 20 Hz and 40 Hz were clearly detected in both groups with no significant difference identified. Consistent with previous findings, right dominance of the 40‐Hz ASSR was observed in both groups. In the TD children, the right‐side 40‐Hz ASSR was correlated with age. The Kaufmann Assessment Battery for Children score was correlated with the left‐side 40‐Hz ASSR in both groups. Conclusion Right‐dominant ASSR was successfully detected in young TD children and children with ASD. No difference in ASSR was observed between the children with ASD and the TD children, although the right‐side 40‐Hz ASSR increased with age only in the TD children. Left‐side 40‐Hz ASSR was associated with intelligence score in both groups.

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Section: Studies Of Auditory Steady‐state Responsementioning

confidence: 99%

“…The children were younger than those of previous studies (Table ), and a narrow age range was chosen for this study to avoid the variation with age shown previously. Because ASSR is prominent at rates near 40 Hz according to almost all studies examining 40‐Hz ASSR, ASSR at 40 Hz was measured.…”

Section: Studies Of Auditory Steady‐state Responsementioning

confidence: 99%

Auditory steady‐state response at 20 Hz and 40 Hz in young typically developing children and children with autism spectrum disorder

Kudoh

Ikeda

Takahashi

et al. 2020

Psychiatry Clin Neurosci

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“…Other mental conditions such as bipolar disorder or affective psychosis show similar ASSR deficits, indicating that ASSR may provide a useful index for distinguishing these conditions from major depressive disorder ( 12 , 16 ). However, the utility of ASSR as a biomarker remains limited by the small sample size (<100) in these studies.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Test-Retest Reliability of Auditory Gamma Oscillations Between Different Clinical EEG Systems

et al. 2020

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Objective There is increasing interest in the utility of gamma-band activity for assessing various brain functions, including perception, language, memory, and cognition. The auditory steady-state response (ASSR) involves neural activity in the brain elicited by trains of a click sound, and its maximum response is obtained at 40 Hz (40-Hz ASSR). Abnormalities of the 40-Hz ASSR are also widely reported in patients with schizophrenia. Thus, the test-retest reliability of the ASSR is important for its clinical and translational application. However, there are only limited studies reporting the short-term reliability between acquisitions at two time points made using the same electroencephalogram (EEG) system. Furthermore, the long-term reliability between multiple EEG systems and the reliability of spontaneous gamma activity are unknown but are crucial for multicenter collaborative research. Methods We examined the long-term test–retest reliability of 40-Hz ASSR oscillatory activities indexed by the phase locking factor (PLF), evoked power, and (non-phase-locked) induced power between two clinical 19-electrode EEG systems [recorded twice for EEG-1 (time1 and time2) and EEG-2 (time3 and time4)] at four time points from 14 healthy controls over a duration of 5 months. Test-retest reliability was examined using intraclass correlation coefficients (ICCs). Results Both PLF and evoked power showed good to excellent ICCs (>0.60), mainly in the Fz-electrode, both within each EEG system—EEG-1 [(time1 vs. time2) PLF: ICC = 0.66, evoked power: ICC = 0.88] and EEG-2 [(time3 vs. time4) PLF: ICC = 0.82, evoked power: ICC = 0.77]—and between the two EEG systems [(EEG-1 vs. EEG-2) PLF: ICC = 0.73, evoked power: ICC = 0.84]. In contrast, induced power showed the highest (excellent) ICC between the two EEG systems (ICC = 0.95) mainly in the Cz-electrode. For PLF, the Fz-electrode showed better test-retest reliability across all EEG recordings than the Cz-electrode (Fz: ICC = 0.67, Cz: ICC = 0.63), whereas we found similar excellent reproducibility across all EEG recordings from both electrodes for evoked power (Fz: ICC = 0.79, Cz: ICC = 0.77) and induced power (Fz: ICC = 0.79, Cz: ICC = 0.80). Conclusion The 40-Hz ASSR oscillatory activities, including induced power, showed excellent test-retest reliability, even when using different EEG systems over a duration of 5 months. These findings confirm the utility of the 40-Hz ASSR as a reliable clinical and translatable biomarker for multicenter collaborative research.

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“…40 Hz amplitude-modulated stimuli (e.g., amplitude-modulated tones, white noise, or click trains) can be used to entrain the ASSR, which peaks around 40 Hz in humans (Azzena et al, 1995; Hari et al, 1989) and can be measured using electroencephalography (EEG) or magnetoencephalography (MEG). ASSR abnormalities have been observed in autism spectrum disorders (Wilson et al, 2007), schizophrenia (Brenner et al 2003; Hayrynen et al, 2016; Kwon et al, 1999; Light et al, 2006; O’Donnell et al, 2013; Roach et al, 2013; Spencer et al, 2008; Thune et al, 2016), and bipolar disorder (Isomura et al, 2016; Maharajh et al, 2007; O’Donnell et al, 2004; Oda et al, 2012; Rass et al, 2010). Heritability of these abnormalities has been suggested, as they have also been identified in first-degree relatives of individuals with autism (Rojas et al, 2011) and schizophrenia (Hong et al, 2004; Rass et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

MEG and EEG demonstrate similar test-retest reliability of the 40 Hz auditory steady-state response

Legget

Hild

Steinmetz

et al. 2017

International Journal of Psychophysiology

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The auditory steady-state response (ASSR) is increasingly being used as a biomarker in neuropsychiatric disorders, but research investigating the test-retest reliability of this measure is needed. We previously reported ASSR reliability, measured by electroencephalography (EEG), to 40 Hz amplitude-modulated white noise and click train stimuli. The purpose of the current study was to (a) assess the reliability of the MEG-measured ASSR to 40 Hz amplitude-modulated white noise and click train stimuli, and (b) compare test-retest reliability between MEG and EEG measures of ASSR, which has not previously been investigated. Additionally, impact of stimulus parameter choice on reliability was assessed, by comparing responses to white noise and click train stimuli. Test-retest reliability, across sessions approximately one week apart, was assessed in 17 healthy adults. On each study day, participants completed two passive listening tasks (white noise and click train stimuli) during separate MEG and EEG recordings. Between-session correlations for evoked power and inter-trial phase coherence (ITPC) were assessed following source-space projection. Overall, the MEG-measured ASSR was significantly correlated between sessions (p < 0.05, FDR corrected), suggesting acceptable test-retest reliability. Results suggest greater response reproducibility for ITPC compared to evoked responses and for click train compared to white noise stimuli, although further study is warranted. No significant differences in reliability were observed between MEG and EEG measures, suggesting they are similarly reliable. This work supports use of the ASSR as a biomarker in clinical interventions with repeated measures.

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Differentiation between major depressive disorder and bipolar disorder by auditory steady-state responses

Abstract: We could differentiate between MDD and BD subjects in terms of gamma band ASSR. Our data suggest that the 40-Hz ASSR may be a potential biomarker for differentiation between MDD and BD patients.

Cited by 87 publications

References 39 publications

Auditory steady‐state response at 20 Hz and 40 Hz in young typically developing children and children with autism spectrum disorder

Auditory steady‐state response at 20 Hz and 40 Hz in young typically developing children and children with autism spectrum disorder

Long-Term Test-Retest Reliability of Auditory Gamma Oscillations Between Different Clinical EEG Systems

MEG and EEG demonstrate similar test-retest reliability of the 40 Hz auditory steady-state response

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