Differentiation Between the Embryonic and Tumour Specific Antigens on Chemically Induced Rat Tumours

Baldwin, Robert; Glaves, Dorothy; Vose, Brent M

doi:10.1038/bjc.1974.1

Cited by 23 publications

(3 citation statements)

References 18 publications

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“…From the results of these studies, it appears that resistance to tumors in mice after pregnancy is mediated by T lymphocytes. [27][28][29] Our studies show that the fetal antigen-sensitized effector cells taking part in antitumor immune response are primarily T cells. The subset ofT cells mediating antitumor immune response was identified as Lyt-l + in our study.…”

Section: Discussionmentioning

confidence: 72%

Inhibition of Tumor Growth and Metastases in Mice Bearing a Malignant Fibrosarcoma by T Cell‐Mediated Immune Response to Oncofetal Antigens

Gautam¹,

Deodhar²

1983

American Journal of Reproductive Immunology

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The presence of fetal antigens on a wide variety of tumors has been well-documented, and it has been attributed, for the most part, to de-repression of genes normally operative in the early stages of embryonic development. Controversy still exists, however, about the role of fetal antigens in antitumor immunity. It is not clear whether the tumor inhibition shown in some systems is due to an immune response. In the present study, conducted in a weakly immunogenic Lewis T241 fibrosarcoma, syngeneic for C57BlJ 6J mice, immunization of normal mice with syneneic fetal cells resulted in striking inhibition of growth and metastases of tumors. On the other hand, immunization with syngeneic normal, adult spleen cells or with allogeneic A/J fetal cells did not inhibit tumor growth or metastases. Mice that had gone through single pregnancy also showed inhibition in tumor growth and metastases. Immunization of female mice with syngeneic tumor cells or fetal cells, prior to pregnancy, resulted in a high incidence of fetal death in these mice. Further studies showed that tumor inhibitory response evoked by fetal cell immunization was due to fetal antigens, and the male-specific HY antigen was not responsible for antitumor response. When tumor cells were mixed with spleen cells from fetal antigen-immunized mice and then injected into normal mice (Winn neutralization assay), significant inhibition of tumor growth and metastases was observed. In this assay, mixing tumor cells with syngeneic fetal cells, normal adult spleen cells, or spleen cells from C57 mice immunized with allogeneic fetal cells did not inhibit the tumor growth or metastases. These results show that inhibition in tumor growth and metastases, following fetal cell immunization, was due to a specific immune response to the oncofetal antigens involved. Analysis of effector cells showed them to be T cells of Lyt-l + and Lyt-~phenotype.

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Section: Discussionmentioning

confidence: 72%

Inhibition of Tumor Growth and Metastases in Mice Bearing a Malignant Fibrosarcoma by T Cell‐Mediated Immune Response to Oncofetal Antigens

Gautam¹,

Deodhar²

1983

American Journal of Reproductive Immunology

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“…Although the methylcholanthrene-induced sarcoma, Mc7, has been found to provoke both humoral (Baldwin el al., 1971) and cell-mediated (Baldwin et al, 1974) immune responses against tumor-associated antigens in syngeneic Wistar rats, it is not clear what immune processes are dominant in expression of host resistance to tumor growth. To examine in vivo host resistance to this tumor, the present study characterizes lymphocytes that are operative in mediating suppression of tumor growth under conditions that would be expected to prevail in an intact tumor-resistant animal.…”

Section: Discussionmentioning

confidence: 99%

Lymphocytes that mediate systemic resistance to in vivo growth of a carcinogen‐induced syngeneic tumor

Crum

1980

Intl Journal of Cancer

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Wistar rats immunized with irradiated syngeneic methylcholanthrene-induced sarcoma, Mc7, are able to suppress a subsequent challenge of this tumor. Cells obtained from thoracic-duct lymph of these tumor-immunized animals and infused intravenously into normal syngeneic rats transfer specific tumor resistance to the recipients. These mediators of tumor resistance have the characteristics of T lymphocytes that are in a nonproliferating state and have an effective life span at least 2 weeks in normal recipient rats.

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“…These postulates have been analysed comprehensively using a range of immunogenic rat tumours including 3-methyleholanthrene (Mc) induced sarcomata and 4-dimethylaminoazobenzene (DAB) induced hepotomata maintained by transplantation in syngeneic Wistar rats (Baldwin, Glaves and Pimm, 1971; Baldwin et al, 1 972a; Baldwin, Glaves and Vose, 1972b;Baldwin et al, 1974a). From these studies it was concluded that embryonic antigen expression was a concomitant of malignant change, although it was possible to differentiate between these antigens and the tumour rejection antigens by their specificities (Baldwin et al, 1972(Baldwin et al, , 1974aBaldwin, Glaves and Vose, 1974b).…”

mentioning

confidence: 99%

Embryonic Antigen Expression on 2-Acetylaminofluorene Induced and Spontaneously Arising Rat Tumours

Baldwin¹,

Vose²

1974

Br J Cancer

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Summary.-2-Acetylaminofluorene induced mammary and ear duct carcinomata and spontaneously arising mammary carcinomata and sarcomata were shown to express embryonic antigens at the cell surface by their reaction with serum from multiparous female rats. These observations with essentially non-immunogenic tumours are comparable with early findings showing that embryonic antigens are also expressed on aminoazo dye induced rat hepatomata, and sarcomata induced with 3-methylcholanthrene. Re-expression of embryonal components, therefore, may be a concomitant of neoplastic transformation.

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Differentiation Between the Embryonic and Tumour Specific Antigens on Chemically Induced Rat Tumours

Cited by 23 publications

References 18 publications

Inhibition of Tumor Growth and Metastases in Mice Bearing a Malignant Fibrosarcoma by T Cell‐Mediated Immune Response to Oncofetal Antigens

Inhibition of Tumor Growth and Metastases in Mice Bearing a Malignant Fibrosarcoma by T Cell‐Mediated Immune Response to Oncofetal Antigens

Lymphocytes that mediate systemic resistance to in vivo growth of a carcinogen‐induced syngeneic tumor

Embryonic Antigen Expression on 2-Acetylaminofluorene Induced and Spontaneously Arising Rat Tumours

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