Differentiation of a calsequestrin-containing endoplasmic reticulum during sea urchin oogenesis

Henson, Joan M.; Beaulieu, Stephen; Kaminer, Benjamin; Begg, David A.

doi:10.1016/0012-1606(90)90347-l

Cited by 31 publications

(13 citation statements)

References 70 publications

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“…For example, neurons display an extensive ER network extending from the cell body to the tips of the dendrites that could be involved in calcium regulation . During early development, the ER plays an essential function in calcium regulation at fertilization, a role attributed to a specialized subcortical layer of ER in some organisms [Sardet, 1984;Henson et al, 1990;Terasaki et al, 2001]. …”

Section: Introductionmentioning

confidence: 99%

Dynamics of the endoplasmic reticulum during early development of Drosophila melanogaster

Bobinnec

Marcaillou

Morin

et al. 2003

Cell Motil. Cytoskeleton

108

109

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In this study, we analyze for the first time endoplasmic reticulum (ER) dynamics and organization during oogenesis and embryonic divisions of Drosophila melanogaster using a Protein Disulfide Isomerase (PDI) GFP chimera protein. An accumulation of ER material into the oocyte takes place during the early steps of oogenesis. The compact organization of ER structures undergoes a transition to an expanded reticular network at fertilization. At the syncytial stage, this network connects to the nuclear envelope as each nucleus divides. Time-lapse confocal microscopy on PDI transgenic embryos allowed us to characterize a rapid redistribution of the ER during the mitotic phases. The ER network is massively recruited to the spindle poles in prophase. During metaphase most of the ER remains concentrated at the spindle poles and shortly thereafter forms several layers of membranes along the ruptured nuclear envelope. Later, during telophase an accumulation of ER material occurs at the spindle equator. We also analyzed the subcellular organization of the ER network at the ultrastructural level, allowing us to corroborate the results from confocal microscopy studies. This dynamic redistribution of ER suggests an unexpected regulatory function for this organelle during mitosis.

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Section: Introductionmentioning

confidence: 99%

Dynamics of the endoplasmic reticulum during early development of Drosophila melanogaster

Bobinnec

Marcaillou

Morin

et al. 2003

Cell Motil. Cytoskeleton

108

109

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“…There are structural ER changes in oocytes in all six species examined to date: frog (Campanella and Andreucetti, 1977;Gardiner and Gray, 1983;Campanella et al, 1984;Charbonneau and Gray, 1984), sea urchin (Henson et al, 1990), starfish (Jaffe and Terasaki, 1994), mouse (Mehlmann et al, 1995), hamster (Shiraishi et al, 1995), and the nemertean worm Cerebratulus lacteus (Stricker et al, 1998). The ER also undergoes drastic structural changes at fertilization in some species but not others (see DISCUSSION).…”

Section: Introductionmentioning

confidence: 99%

Changes in Organization of the Endoplasmic Reticulum duringXenopusOocyte Maturation and Activation

Terasaki¹,

Runft²,

Hand

2001

MBoC

119

135

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The organization of the endoplasmic reticulum (ER) in the cortex of Xenopus oocytes was investigated during maturation and activation using a green fluorescent protein chimera, immunofluorescence, and electron microscopy. Dense clusters of ER developed on the vegetal side (the side opposite the meiotic spindle) during maturation. Small clusters appeared transiently at the time of nuclear envelope breakdown, disappeared at the time of first polar body formation, and then reappeared as larger clusters in mature eggs. The appearance of the large ER clusters was correlated with an increase in releaseability of Ca 2ϩ by IP 3 . The clusters dispersed during the Ca 2ϩ wave at activation. Possible relationships of ER structure and Ca 2ϩ regulation are discussed.

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“…The ER plays an important role during fertilization by regulating the intracellular Ca 2ϩ concentration. In some organisms, this function is attributed to a specialized subcortical layer of ER (Henson et al, 1990;Terasaki et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Involvement of the Actin Cytoskeleton and Homotypic Membrane Fusion in ER Dynamics inCaenorhabditis elegans

Poteryaev

Squirrell

Campbell

et al. 2005

MBoC

140

174

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The endoplasmic reticulum (ER) is the major intracellular membrane system. The ER is essential for protein and lipid biosynthesis, transport of proteins along the secretory pathway, and calcium storage. Here, we describe our investigations into the dynamics and regulation of the ER in the early Caenorhabditis elegans embryo. Using a GFP fusion to the ER-resident signal peptidase SP12, we observed the morphological transitions of the ER through fertilization and the early cell-cycles in living embryos. These transitions were tightly coordinated with the division cycle: upon onset of mitosis, the ER formed structured sheets that redispersed at the initiation of cleavage. Although microtubules were not required for the transition of the ER between these different states, the actin cytoskeleton facilitated the dispersal of the ER at the end of mitosis. The ER had an asymmetric distribution in the early embryo, which was dependent on the establishment of polarity by the PAR proteins. The small GTPase ARF-1 played an essential role in the ER dynamics, although this function appeared to be unrelated to the role of ARF-1 in vesicular traffic. In addition, the ER-resident heat shock protein BiP and a homologue of the AAA ATPase Cdc48/p97 were found to be crucial for the ER transitions. Both proteins have been implicated in homotypic ER membrane fusion. We provide evidence that homotypic membrane fusion is required to form the sheet structure in the early embryo.

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Differentiation of a calsequestrin-containing endoplasmic reticulum during sea urchin oogenesis

Cited by 31 publications

References 70 publications

Dynamics of the endoplasmic reticulum during early development of Drosophila melanogaster

Dynamics of the endoplasmic reticulum during early development of Drosophila melanogaster

Changes in Organization of the Endoplasmic Reticulum duringXenopusOocyte Maturation and Activation

Involvement of the Actin Cytoskeleton and Homotypic Membrane Fusion in ER Dynamics inCaenorhabditis elegans

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