Differentiation of astrocytes with characteristics of ventral midbrain from human embryonic stem cells

Yeon, Gyu-Bum; Jeon, Byeong-Min; Yoo, Seo Hyun; Kim, Dongyun; Oh, Seung Soo; Park, Sang‐Hyun; Shin, Won-Ho; Kim, Hyung Wook; Na, Dokyun; Kim, Dong-Wook; Kim, Dae-Sung

doi:10.1007/s12015-023-10536-y

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2023

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“…Hence, there is a need for methods to improve gliogenesis in brain organoids within experimentally tractable time frames. Given recent evidence that astrocytes and oligodendrocytes possess brain region-specific molecular and functional characteristics [ 62 ], updated protocols that can incorporate region-specific glia may improve the differentiation and survival of neurons in brain organoids.…”

Section: Biological Relevance Of Mlosmentioning

confidence: 99%

Midbrain organoids—development and applications in Parkinson’s disease

Toh,

Choo,

Sun

2023

Oxford Open Neuroscience

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Human brain development is spatially and temporally complex. Insufficient access to human brain tissue and inadequacy of animal models have limited the study of brain development and neurodegenerative diseases. Recent advancements of brain organoid technology have created novel opportunities to model human-specific neurodevelopment and brain diseases. In this review, we discuss the use of brain organoids to model the midbrain and Parkinson’s disease. We critically evaluate the extent of recapitulation of PD pathology by organoids and discuss areas of future development that may lead to the model to become a next generation, personalized therapeutic strategy for PD and beyond.

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Section: Biological Relevance Of Mlosmentioning

confidence: 99%