1984
DOI: 10.1016/0006-8993(84)90653-x
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Differentiation of basal ganglia dopaminergic involvement in behavior after hippocampectomy

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Cited by 27 publications
(10 citation statements)
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“…This moderate elevation of activity suggests that the biological changes associated with this e¤ect are not dramatic and do not involve complete changes in neurotransmitter function. However, there appears to be a clear similarity between the increased activity in KA-lesioned animals and animals with site-speciÞc lesions of limbic-cortical areas (Kolb 1977;Devenport et al 1981;Handelmann and Olton 1981;Reinstein et al 1982;Fass 1983;Nyakas et al 1983;Hannigan et al 1984;Emerich and Walsh 1990;Lorenzini et al 1991;Port et al 1991;Whishaw and Mittleman 1991;Burns et al 1993;Lipska et al 1993;Wilkinson et al 1993). These previous studies, along with our own Þndings, suggest that regions such as the hippocampus, amygdala, thalamus, and entorhinal cortex exert a signiÞcant modulatory inßuence over locomotor activity.…”
Section: Discussionsupporting
confidence: 62%
See 1 more Smart Citation
“…This moderate elevation of activity suggests that the biological changes associated with this e¤ect are not dramatic and do not involve complete changes in neurotransmitter function. However, there appears to be a clear similarity between the increased activity in KA-lesioned animals and animals with site-speciÞc lesions of limbic-cortical areas (Kolb 1977;Devenport et al 1981;Handelmann and Olton 1981;Reinstein et al 1982;Fass 1983;Nyakas et al 1983;Hannigan et al 1984;Emerich and Walsh 1990;Lorenzini et al 1991;Port et al 1991;Whishaw and Mittleman 1991;Burns et al 1993;Lipska et al 1993;Wilkinson et al 1993). These previous studies, along with our own Þndings, suggest that regions such as the hippocampus, amygdala, thalamus, and entorhinal cortex exert a signiÞcant modulatory inßuence over locomotor activity.…”
Section: Discussionsupporting
confidence: 62%
“…The hyperlocomotion observed in animals with limbic-cortical lesions may arise as a direct consequence of limbic-cortical neuronal loss, independent of disruptions in limbic input to subcortical locomotor systems. Alternatively, as many authors have suggested, lesion-induced hypermotility may reßect the loss of limbic input into subcortical brain regions which regulate locomotor behavior (Devenport et al 1981;Reinstein et al 1982;Hannigan et al 1984;Emerich and Walsh 1990;Whishaw and Mittleman 1991;Lipska et al 1993;Wilkinson et al 1993).…”
Section: Discussionmentioning
confidence: 96%
“…The mapping of a new environment is generally believed to involve limbic brain areas including hippocampus and a functional DA-neurotransmission (Hannigan et al 1984;Reinstein et al 1982). The importance of DA can be demonstrated by using a low dose of apomorphine or other DA autoreceptor agonists, which in addition to hypomotility cause a decrease in exploratory behaviour (StAhle & Ungersteds 1986).…”
Section: Discussionmentioning
confidence: 99%
“…amygdalar dopamine projections (Simon et al 1988;Lipska et al 1992;Joseph et al 2000). Furthermore, hippocampectomy affects this system in ways that evolve, recover, and even change sign over time (Lanier et al 1975;Hannigan Jr. et al 1984;Lipska et al 1992). Perhaps hippocampal inactivation causes changes in the accumbens dopamine circuit that are countered by opposing changes in taste-related branches of the dopamine circuitry (a related argument has been made with regard to latent inhibition; see Ellenbroek et al 1997); these latter changes would be expected to reverse the typical damaging effect of the hippocampal lesion.…”
Section: Discussionmentioning
confidence: 99%
“…Such lesions have complex effects, downregulating some systems and upregulating others; during the 1-2 wk of recovery that must pass before rats with permanent lesions are healthy enough to participate in experiments, these changes evolve in a way that may extend, mask, or compensate for acute loss of hippocampal activity (e.g., Hannigan Jr. et al 1984;Simon et al 1988;Lipska et al 1992). Because particular parts of the systems that interact with the hippocampus are deeply involved in sensory aspects of CTA (Reilly and Bornovalova 2005), it is possible that temporary hippocampal inactivations might have an effect, even a facilitory one, on CTA, despite the lack of such effects observed on the majority of tasks.…”
mentioning
confidence: 99%