Differentiation of benign and malignant parotid tumors using deconvolution-based perfusion CT imaging: Feasibility of the method and initial results

Bisdas, Sotirios; Baghi, Mehran; Wagenblast, Jens; Knecht, Rainald; Thng, Choon Hua; Koh, Tong San; Vogl, Thomas J.

doi:10.1016/j.ejrad.2007.02.032

Cited by 61 publications

(78 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inconsistent with the present results, a study by using perfusion CT imaging showed that blood volumes of malignant salivary gland tumors were significantly lower than those of benign salivary gland tumors. 17 In the present study, however, we found that the f values of malignant salivary gland tumors were significantly higher than those of pleomorphic adenomas. The discrepancy between these studies implies that the tumor perfusion estimated on the basis of contrast-enhanced imaging techniques differs from the tumor perfusion estimated on the basis of the DWI technique.…”

Section: Discussioncontrasting

confidence: 54%

Head and Neck Tumors: Assessment of Perfusion-Related Parameters and Diffusion Coefficients Based on the Intravoxel Incoherent Motion Model

Sumi

Nakamura

2012

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 54%

Head and Neck Tumors: Assessment of Perfusion-Related Parameters and Diffusion Coefficients Based on the Intravoxel Incoherent Motion Model

Sumi

Nakamura

2012

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…We observed that in infiltrated muscles, BF, BV and PS values were almost twice as high as in non-infiltrated contralateral structures. This observation is in agreement with previous studies of Bisdas et al [13,17], who observed significantly lower (p < 0.001) perfusion values for unchanged tongue, paraspinous and sternocleidomastoid muscles, in comparison to the pathological contralateral site. This finding also supports the thesis that perfusion imaging may be a powerful tool for imaging activity of the tumour and its infiltrative pattern, before the tumour proceeds in a gross anatomical distortion.…”

Section: Discussionsupporting

confidence: 83%

“…This technique is being gradually applied in the diagnosis, staging and prognostic evaluation of tumours, as well as for therapeutic response monitoring [12]. In particular, the latest publications indicate that CTP could provide useful information for differentiation between squamous cell cancer (SCC) and normal tissue [10,12,13]. This finding is attributed to the enlarged and hyper-permeable neovascular bed as a consequence of tumoural neoangiogenesis.…”

Section: Introductionmentioning

confidence: 99%

Head and neck squamous cell cancer – the role of computed tomography enhanced with perfusion imaging in tumour staging

Trojanowska¹,

Trojanowski²,

Drop³

et al. 2011

View full text Add to dashboard Cite

A Ai im m o of f t th he e s st tu ud dy y: : To determine the added value of computed tomography perfusion (CTP) images combined with contrast-enhanced computed tomography (CECT) images in staging of head and neck squamous cell cancer (SCC). M Ma at te er ri ia al l a an nd d m me et th ho od ds s: : Forty-seven consecutive patients with histologically proven squamous cell cancer of the head and neck and qualified for surgical treatment were prospectively evaluated in 2 groups: based on CECT multiplanar reformations (axial, coronal and sagittal), and separately, based on CTP images combined with CECT data. Tumour stage was assessed in each group separately, with special emphasis on T4 stage, and results were compared with histological findings. Five patients underwent endoscopic laser tumour resection, 11 underwent other tumour resection (glossectomy, pharyngectomy) and 31 patients underwent en-bloc resection of the hypopharynx and larynx, allowing detailed pathological evaluation of possible tumour infiltration into surrounding structures. Two experienced head and neck radiologists evaluated the images.Inter-observer agreement was tested with the modified κ test. The χ 2 test was applied to compare the number of correctly staged tumours for the two methods and readers. R Re es su ul lt ts s: : Inter-observer agreement was high (k = 0.88-0.90). Significant differences between the two groups were observed; with added CTP assessment more anatomical structures were rated positive for tumour infiltration and diagnostic accuracy of this method was significantly higher when compared to CECT images. Sole evaluation of CECT images in less advanced cases led to overestimation of the disease, since inflammation and slight oedema could not be differentiated from tumour. C Co on nc cl lu us si io on ns s: : Contrast-enhanced computed tomography multi-planar images enhanced with CTP images were proven to improve accuracy in head and neck cancer staging. The added value of CTP may help to avoid overestimation of the malignant process and at the same time may facilitate depiction all infiltrated structures.K Ke ey y w wo or rd ds s: : CT perfusion, squamous cell cancer, TNM, computed tomography.

show abstract

“…[7][8][9][10] CTP is now recognized as an important method that can provide valuable information in patients with head and neck masses. 7,[11][12][13][14] The purpose of this study is to investigate the TDC types and perfusion parameters in the diagnosis and differentiation of parotid lesions.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of CT perfusion imaging for parotid neoplasms

Dong

Gw²,

Sw³

et al. 2014

Dentomaxillofacial Radiology

View full text Add to dashboard Cite

Objectives: To assess the value of CT perfusion imaging in the differentiation of different histological categorization of benign tumours from malignant tumours in patients with parotid neoplasms. Methods: CT perfusion was successfully performed in 62 patients with parotid neoplasms whose diagnoses were confirmed by surgery or biopsy. The software generated a tissue time-density curve (TDC) and measured blood volume, blood flow, mean transit time and capillary permeability surface product. One-way ANOVA and receiver operating characteristic curves were used to analyse the difference and diagnostic efficacies of all perfusion data between each one of the benign tumours and malignancies. Statistical significance was assigned at the 5% level. Results: Pleomorphic adenomas mainly had a gradually ascending TDC. Warthin tumours showed a fast ascent followed by a fast descent. The TDC of basal cell adenomas had a fast ascension followed by a plateau, then a gradual descent. Malignant tumours mainly showed a rapidly ascending curve with a stable plateau. Significant differences were observed in blood flow, blood volume and mean transit time between pleomorphic adenomas and malignant tumours (p , 0.05) as well as in blood flow and blood volume between the Warthin tumours, the basal cell adenomas and the malignant tumours (p , 0.05). Differences in permeability surface between the basal cell adenomas and malignant tumours were significant (p , 0.01). Conclusion: CT perfusion of parotid gland could provide TDC and perfusion data, which were useful in the differentiation of different histological benign tumours and malignant tumours in the parotid gland.

show abstract

Differentiation of benign and malignant parotid tumors using deconvolution-based perfusion CT imaging: Feasibility of the method and initial results

Cited by 61 publications

References 15 publications

Head and Neck Tumors: Assessment of Perfusion-Related Parameters and Diffusion Coefficients Based on the Intravoxel Incoherent Motion Model

Head and Neck Tumors: Assessment of Perfusion-Related Parameters and Diffusion Coefficients Based on the Intravoxel Incoherent Motion Model

Head and neck squamous cell cancer – the role of computed tomography enhanced with perfusion imaging in tumour staging

Diagnostic value of CT perfusion imaging for parotid neoplasms

Contact Info

Product

Resources

About