Differentiation of benign from malignant cervical lymph nodes in patients with head and neck cancer using PET/CT imaging

Payabvash, Seyedmehdi; Meriç, Kaan; Cayci, Zuzan

doi:10.1016/j.clinimag.2015.09.001

Cited by 25 publications

(16 citation statements)

References 30 publications

(45 reference statements)

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“…38 In addition, in a comparative study of benign and malignant lesions, Patel et al concluded that increased perfusion can also occur in benign lesions. 39 Our results showed no correlation between f values and SUV max , MTV, and TLG values in lung adenocarcinoma. This finding may provide some information for discussing the mechanisms underlying the heterogeneity of vascular distribution in lung adenocarcinoma.…”

Section: Discussioncontrasting

confidence: 73%

“…However, another study, also about breast cancer, concluded that SUV values were positively correlated with microvessel density 38 . In addition, in a comparative study of benign and malignant lesions, Patel et al concluded that increased perfusion can also occur in benign lesions 39 . Our results showed no correlation between f values and SUV max , MTV, and TLG values in lung adenocarcinoma.…”

Section: Discussioncontrasting

confidence: 71%

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Application of Simultaneous ¹⁸F‐FDG PET With Monoexponential, Biexponential, and Stretched Exponential Model‐Based Diffusion‐Weighted MR Imaging in Assessing the Proliferation Status of Lung Adenocarcinoma

Huang

Wang

et al. 2021

Magnetic Resonance Imaging

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Background Ki‐67 proliferation index (PI) is important for providing information on tumor behavior, treatment response, and prognosis. Integrated positron emission tomography/magnetic resonance (PET/MR) may have the potential to assess Ki‐67 PI in patients with lung adenocarcinoma. Purpose To explore the value of simultaneous 18F‐fluorodeoxyglucose (18F‐FDG) PET/MR‐derived parameters in assessing the proliferation status of lung adenocarcinoma and to determine the best combination of parameters. Study Type Prospective. Population Seventy‐eight patients with lung adenocarcinoma and with Ki‐67 PI. Field Strength/Sequence 3.0 T, simultaneous PET/MRI including diffusion‐weighted imaging (DWI) and 18F‐FDG PET. Assessment DWI‐derived parameters, namely, apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo diffusion coefficient (D*), perfusion fraction (f), diffusion heterogeneity index (α), and distributed diffusion coefficient (DDC); and PET‐derived parameters, namely, maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolytic volume (TLG), were calculated and compared between the high (>25%) and low (≤25%) Ki‐67 PI groups. The correlations between PET‐derived parameters and DWI‐derived parameters were analyzed. Statistical Tests Student's t‐test, Mann–Whitney U test, chi‐square test, and receiver operating characteristic (ROC) curves. A P‐value <0.05 was considered statistically significant. Results The SUVmax, MTV, TLG, ADC, D, and DDC values were significantly different between the high (N = 35) and low Ki‐67 PI groups (N = 43). D, SUVmax, and MTV independently predicted the Ki‐67 PI status. The combination of D, SUVmax, and MTV had the largest area under the ROC curve (AUC = 0.900), which was significantly larger than the AUC alone of DDC (AUC = 0.725), SUVmax (AUC = 0.815), MTV (AUC = 0.774), or TLG (AUC = 0.783). The perfusion fraction did not correlate with SUVmax, MTV, or TLG (r = −0.03, −0.11, and −0.04, respectively; P = 0.786, 0.348, and 0.733). Data Conclusion The combination of D, SUVmax, and MTV may predict Ki‐67 PI status. No correlation was observed between perfusion parameters and metabolic parameters. Level of Evidence 1 Technical Efficacy Stage 2

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Section: Discussioncontrasting

confidence: 73%

Section: Discussioncontrasting

confidence: 71%

Application of Simultaneous ¹⁸F‐FDG PET With Monoexponential, Biexponential, and Stretched Exponential Model‐Based Diffusion‐Weighted MR Imaging in Assessing the Proliferation Status of Lung Adenocarcinoma

Huang

Wang

et al. 2021

Magnetic Resonance Imaging

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“…Nodal metastases herald poor prognosis in patients with head and neck cancer, and their detection is important for treatment planning, extent of radiation treatment field, or surgical neck dissection method. Currently, the differentiation of metastatic lymphadenopathy primarily relies on size criteria; however, nonenlarged nodes may harbor malignancy, and reactive nodes may be prominently enlarged (45). In addition, in patients presenting with suspicious cervical lymphadenopathy, differentiation of lymphoma from metastatic lymph nodes of unknown primary cancer site can be challenging.…”

Section: Reactive Versus Metastatic Lymphadenopathymentioning

confidence: 99%

Quantitative diffusion magnetic resonance imaging in head and neck tumors

Payabvash

2018

Quant. Imaging Med. Surg

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In patients with head and neck cancer, conventional anatomical magnetic resonance imaging (MRI) scans are commonly used for identification of primary lesion, assessment of structural distortion, and presence of metastatic lymph nodes. However, quantitative analysis of diffusion MRI can provide added value to structural and anatomical evaluation of head and neck tumors (HNT), by differentiation of primary malignant process, prognostic prediction, and treatment monitoring. In this article, we will review the applications of quantitative diffusion MRI in identification of primary malignant tissue, differentiation of tumor pathology, prediction of molecular phenotype, monitoring of treatment response, and evaluation of posttreatment changes in patient with HNT.

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“…The SUV max measure has been widely used for detection and differentiation of malignant lymph nodes in cancer patients (21,22). Payabvash et al (23) studied the role of PET/CT in differentiating malignant from benign cervical lymph nodes in patients with head/neck cancer, showing that the SUV max of ≥2.5 can detect malignant lymph nodes with 19% specificity, whereas a cutoff of ≥5.5 has 100% specificity for detection of malignant lymph nodes. However, in the present cases, an enlarged lymph node with SUV max of 5.8 was also identified as TB.…”

Section: Discussionmentioning

confidence: 99%

Lymph node tuberculosis mimicking malignancy on 18F-FDG PET/CT in two patients: A case report

Ding

Cao

et al. 2017

Experimental and Therapeutic Medicine

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18F-fluorodeoxyglucose positron emission/computed tomography (18F-FDG PET/CT) imaging, an established procedure for evaluation of malignancy, reports an increased 18F-FDG uptake in acute or chronic inflammatory condition. Lymph node tuberculosis (LNTB) is the most common form of extrapulmonary tuberculosis. However, the absence of clinical symptoms and bacteriological basis makes it difficult to diagnose. In the current case report, two patients with LNTB mimicking malignant lymphoma are presented by 18F-FDG PET/CT. The objective of the present report is to emphasize that LNTB should be considered as a noteworthy differential diagnosis in patients with enlarged lymph nodes, particularly in tuberculosis-endemic countries, and that lymph node biopsy serves a vital role in diagnosing LNTB.

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Differentiation of benign from malignant cervical lymph nodes in patients with head and neck cancer using PET/CT imaging

Cited by 25 publications

References 30 publications

Application of Simultaneous ¹⁸F‐FDG PET With Monoexponential, Biexponential, and Stretched Exponential Model‐Based Diffusion‐Weighted MR Imaging in Assessing the Proliferation Status of Lung Adenocarcinoma

Application of Simultaneous ¹⁸F‐FDG PET With Monoexponential, Biexponential, and Stretched Exponential Model‐Based Diffusion‐Weighted MR Imaging in Assessing the Proliferation Status of Lung Adenocarcinoma

Quantitative diffusion magnetic resonance imaging in head and neck tumors

Lymph node tuberculosis mimicking malignancy on 18F-FDG PET/CT in two patients: A case report

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Differentiation of benign from malignant cervical lymph nodes in patients with head and neck cancer using PET/CT imaging

Cited by 25 publications

References 30 publications

Application of Simultaneous 18F‐FDG PET With Monoexponential, Biexponential, and Stretched Exponential Model‐Based Diffusion‐Weighted MR Imaging in Assessing the Proliferation Status of Lung Adenocarcinoma

Application of Simultaneous 18F‐FDG PET With Monoexponential, Biexponential, and Stretched Exponential Model‐Based Diffusion‐Weighted MR Imaging in Assessing the Proliferation Status of Lung Adenocarcinoma

Quantitative diffusion magnetic resonance imaging in head and neck tumors

Lymph node tuberculosis mimicking malignancy on 18F-FDG PET/CT in two patients: A case report

Contact Info

Product

Resources

About

Application of Simultaneous ¹⁸F‐FDG PET With Monoexponential, Biexponential, and Stretched Exponential Model‐Based Diffusion‐Weighted MR Imaging in Assessing the Proliferation Status of Lung Adenocarcinoma

Application of Simultaneous ¹⁸F‐FDG PET With Monoexponential, Biexponential, and Stretched Exponential Model‐Based Diffusion‐Weighted MR Imaging in Assessing the Proliferation Status of Lung Adenocarcinoma