There
remains no routine treatment for congenital tracheal abnormalities
affecting more than 1/3 of the length. Natural and artificial prostheses
are plagued by mechanical failure and inconsistent outcomes. Mimicking
native tissue mechanics in an engineered replacement may improve functional
and patient outcomes. We synthesized tubular constructs comprising
photo-cross-linked methyl acrylate-co-methyl methacrylate, p(MA-co-MMA), with patterned r- and z-axes in order to achieve mechanical properties similar
to lamb tracheae. Hard and soft alternating bands, and a soft vertical
section, mimic tracheal architecture. Patterned constructs were capable
of 46% elastic longitudinal extension. The construct longitudinal
composite modulus, 0.34 ± 0.09 MPa, was not significantly different
from ovine tracheae. The superior of two geometries evaluated supports
up to a 46% reduction of internal volume within the physiological
range of transmural pressures. Thus, these patterned hydrogels yielded
longitudinal elasticity and radial rigidity while allowing for radial
deformation required for effective coughing.