This study has been done to compare fourteen cephalometric measurements collected from computerized tracing of digital radiographs followed by manual tracing of the same to check their reliability and reproducibility.Pretreatment lateral cephalograms of fifty subjects were taken, on which fourteen cephalometric measurements were traced. Ten randomly selected cephalograms were retraced by the same operator both manually and digitally.Out of fourteen parameters, eight parameters (N-ANS, S-N, A-Pog, Facial angle, FMA, SNA, SNB and ANB) showed statistically significant differences between the two techniques but were clinically acceptable whereas six parameters did not show any significant differences. Digital measurements obtained from CS8100SC software were reliable for all except ANB. Reproducibility between both the tracing was good except for ANB, Facial axis, Facial angle and FMIA.CS8100SC Imaging software program can be brought into play for cephalometric measurements.